| 1 | Mon Nov 3 | at George Mason | L46-70 | 0-1 | .000 | - | ESPN+ | EagleBank Arena · Fairfax, VA |
| 2 | Sat Nov 8 | vsMilwaukee | W86-76 | 1-1 | .500 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 3 | Tue Nov 11 | at22Auburn | L62-93 | 1-2 | .333 | - | SECN+ | Neville Arena · Auburn, AL |
| 4 | Sat Nov 15 | atBellarmine | W94-86 | 2-2 | .500 | - | ESPN+ | Knights Hall · Louisville, KY |
| 5 | Wed Nov 19 | vsNorth Florida | W86-78 | 3-2 | .600 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 6 | Fri Nov 21 | vsTBD | W81-57 | 4-2 | .667 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 7 | Wed Nov 26 | atN Kentucky | L83-93 | 4-3 | .571 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 8 | Sat Nov 29 | atE Kentucky | W83-77 | 5-3 | .625 | - | ESPN+ | McBrayer Arena · Richmond, KY |
| 9 | Wed Dec 3 | vsPresbyterian | W63-56 | 6-3 | .667 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 10 | Sat Dec 6 | vsElon | L52-73 | 6-4 | .600 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 11 | Mon Dec 15 | atGardner-Webb | W83-57 | 7-4 | .636 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 12 | Wed Dec 17 | atWichita St | L73-84 | 7-5 | .583 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 13 | Sun Dec 28 | vsTBD | W88-54 | 8-5 | .615 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 14 | Wed Dec 31 | atW Carolina | W79-74 | 9-5 | .643 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 15 | Sat Jan 3 | atThe Citadel | W95-86 | 10-5 | .667 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 16 | Wed Jan 7 | vsUNC Greensboro | W97-85 | 11-5 | .688 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 17 | Sat Jan 10 | atMercer | L97-109 | 11-6 | .647 | - | ESPN+ | Hawkins Arena · Macon, GA |
| 18 | Wed Jan 14 | vsChattanooga | L67-76 | 11-7 | .611 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 19 | Sat Jan 17 | atFurman | W74-70 | 12-7 | .632 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 20 | Wed Jan 21 | vsSamford | W88-78 | 13-7 | .650 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 21 | Sat Jan 24 | vsMercer | W80-77 | 14-7 | .667 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 22 | Thu Jan 29 | atChattanooga | W81-55 | 15-7 | .682 | - | ESPN+ | McKenzie Arena · Chattanooga, TN |
| 23 | Sun Feb 1 | vsETSU | L72-86 | 15-8 | .652 | - | CBSSN | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 24 | Wed Feb 4 | atVMI | W81-67 | 16-8 | .667 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 25 | Sat Feb 7 | vsW Carolina | W77-66 | 17-8 | .680 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 26 | Wed Feb 11 | atSamford | L80-97 | 17-9 | .654 | - | ESPN+ | Pete Hanna Center · Homewood, AL |
| 27 | Sat Feb 14 | atUNC Greensboro | L89-99 | 17-10 | .630 | - | ESPN+ | Greensboro Coliseum · Greensboro, NC |
| 28 | Wed Feb 18 | vsVMI | W82-76 | 18-10 | .643 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 29 | Sat Feb 21 | vsFurman | L67-76 | 18-11 | .621 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 30 | Wed Feb 25 | atETSU | W72-69 | 19-11 | .633 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 31 | Sat Feb 28 | vsThe Citadel | L90-93 (OT) | 19-12 | .613 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
