| 1 | Mon Nov 3 | at George Mason | 7:00 PM | 27-9 | .750 | - | ESPN+ | EagleBank Arena · Fairfax, VA |
| 2 | Sat Nov 8 | vsMilwaukee | TBD | 21-11 | .656 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 3 | Tue Nov 11 | at#20Auburn | TBD | 32-6 | .842 | - | | Neville Arena · Auburn, AL |
| 4 | Sat Nov 15 | atBellarmine | TBD | 5-26 | .161 | - | ESPN+ | Knights Hall · Louisville, KY |
| 5 | Wed Nov 19 | vsNorth Florida | TBD | 15-17 | .469 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 6 | Fri Nov 21 | vsTBD | TBD | 0-0 | .000 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 7 | Wed Nov 26 | atN Kentucky | 2:00 PM | 17-16 | .515 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 8 | Sat Nov 29 | atE Kentucky | 5:00 PM | 18-14 | .563 | - | ESPN+ | McBrayer Arena · Richmond, KY |
| 9 | Wed Dec 3 | vsPresbyterian | TBD | 14-19 | .424 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 10 | Sat Dec 6 | vsElon | TBD | 17-16 | .515 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 11 | Mon Dec 15 | atGardner-Webb | 7:00 PM | 11-20 | .355 | - | | Paul Porter Arena · Boiling Springs, NC |
| 12 | Wed Dec 17 | atWichita St | TBD | 19-15 | .559 | - | | Charles Koch Arena · Wichita, KS |
| 13 | Sun Dec 28 | vsTBD | TBD | 0-0 | .000 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 14 | Wed Dec 31 | atW Carolina | TBD | 8-22 | .267 | - | | Ramsey Regional Activity Center · Cullowhee, NC |
| 15 | Sat Jan 3 | atThe Citadel | TBD | 5-25 | .167 | - | | McAlister Field House · Charleston, SC |
| 16 | Wed Jan 7 | vsUNC Greensboro | TBD | 20-12 | .625 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 17 | Sat Jan 10 | atMercer | TBD | 14-19 | .424 | - | | Hawkins Arena · Macon, GA |
| 18 | Wed Jan 14 | vsChattanooga | TBD | 29-9 | .763 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 19 | Sat Jan 17 | atFurman | TBD | 25-10 | .714 | - | | Timmons Arena · Greenville, SC |
| 20 | Wed Jan 21 | vsSamford | TBD | 22-11 | .667 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 21 | Sat Jan 24 | vsMercer | TBD | 14-19 | .424 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 22 | Thu Jan 29 | atChattanooga | TBD | 29-9 | .763 | - | | McKenzie Arena · Chattanooga, TN |
| 23 | Sat Jan 31 | vsETSU | TBD | 19-13 | .594 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 24 | Wed Feb 4 | atVMI | TBD | 15-19 | .441 | - | | Cameron Hall · Lexington, VA |
| 25 | Sat Feb 7 | vsW Carolina | TBD | 8-22 | .267 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 26 | Wed Feb 11 | atSamford | TBD | 22-11 | .667 | - | | Pete Hanna Center · Homewood, AL |
| 27 | Sat Feb 14 | atUNC Greensboro | TBD | 20-12 | .625 | - | | Greensboro Coliseum · Greensboro, NC |
| 28 | Wed Feb 18 | vsVMI | TBD | 15-19 | .441 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 29 | Sat Feb 21 | vsFurman | TBD | 25-10 | .714 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 30 | Wed Feb 25 | atETSU | TBD | 19-13 | .594 | - | | Freedom Hall Civic Center · Johnson City, TN |
| 31 | Sat Feb 28 | vsThe Citadel | TBD | 5-25 | .167 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
