| 2 | Sat Nov 8 | vs Milwaukee | 2:00 PM | 1-0 | 1.000 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 3 | Tue Nov 11 | at#20Auburn | 8:00 PM | 2-0 | 1.000 | - | SECN+ | Neville Arena · Auburn, AL |
| 4 | Sat Nov 15 | atBellarmine | 2:00 PM | 0-1 | .000 | - | ESPN+ | Knights Hall · Louisville, KY |
| 5 | Wed Nov 19 | vsNorth Florida | 7:00 PM | 0-1 | .000 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 6 | Fri Nov 21 | vsTBD | 7:00 PM | 0-0 | .000 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 7 | Wed Nov 26 | atN Kentucky | 2:00 PM | 1-0 | 1.000 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 8 | Sat Nov 29 | atE Kentucky | 5:00 PM | 1-0 | 1.000 | - | ESPN+ | McBrayer Arena · Richmond, KY |
| 9 | Wed Dec 3 | vsPresbyterian | 7:00 PM | 1-1 | .500 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 10 | Sat Dec 6 | vsElon | 4:00 PM | 1-0 | 1.000 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 11 | Mon Dec 15 | atGardner-Webb | 7:00 PM | 0-2 | .000 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 12 | Wed Dec 17 | atWichita St | 7:30 PM | 1-0 | 1.000 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 13 | Sun Dec 28 | vsTBD | 2:00 PM | 0-0 | .000 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 14 | Tue Dec 30 | atW Carolina | 1:00 PM | 0-1 | .000 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 15 | Sat Jan 3 | atThe Citadel | 7:00 PM | 1-1 | .500 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 16 | Wed Jan 7 | vsUNC Greensboro | 6:00 PM | 0-1 | .000 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 17 | Sat Jan 10 | atMercer | 2:00 PM | 1-1 | .500 | - | ESPN+ | Hawkins Arena · Macon, GA |
| 18 | Wed Jan 14 | vsChattanooga | 6:00 PM | 1-1 | .500 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 19 | Sat Jan 17 | atFurman | 6:00 PM | 0-2 | .000 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 20 | Wed Jan 21 | vsSamford | 6:00 PM | 1-1 | .500 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 21 | Sat Jan 24 | vsMercer | 1:00 PM | 1-1 | .500 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 22 | Thu Jan 29 | atChattanooga | 6:00 PM | 1-1 | .500 | - | ESPN+ | McKenzie Arena · Chattanooga, TN |
| 23 | Sat Jan 31 | vsETSU | 2:00 PM | 1-0 | 1.000 | - | CBS | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 24 | Wed Feb 4 | atVMI | 6:00 PM | 2-0 | 1.000 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 25 | Sat Feb 7 | vsW Carolina | 4:00 PM | 0-1 | .000 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 26 | Wed Feb 11 | atSamford | 7:00 PM | 1-1 | .500 | - | ESPN+ | Pete Hanna Center · Homewood, AL |
| 27 | Sat Feb 14 | atUNC Greensboro | 5:00 PM | 0-1 | .000 | - | ESPN+ | Greensboro Coliseum · Greensboro, NC |
| 28 | Wed Feb 18 | vsVMI | 6:00 PM | 2-0 | 1.000 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 29 | Sat Feb 21 | vsFurman | 7:00 PM | 0-2 | .000 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 30 | Wed Feb 25 | atETSU | TBD | 1-0 | 1.000 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 31 | Sat Feb 28 | vsThe Citadel | 2:00 PM | 1-1 | .500 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
