| 1 | Tue Nov 9 | vs TBD | W117-79 | 1-0 | 1.000 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 2 | Fri Nov 12 | atClemson | L68-76 | 1-1 | .500 | - | | Littlejohn Coliseum · Clemson, SC |
| 3 | Mon Nov 15 | vsTBD | W98-41 | 2-1 | .667 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 4 | Fri Nov 19 | vsHampton | W77-60 | 3-1 | .750 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 5 | Sun Nov 21 | vsGeorgia So | W70-52 | 4-1 | .800 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 6 | Tue Nov 23 | atSouth Carolina | L74-85 | 4-2 | .667 | - | | Colonial Life Arena · Columbia, SC |
| 7 | Sun Nov 28 | atGeorgia | W68-65 | 5-2 | .714 | - | | Stegeman Coliseum · Athens, GA |
| 8 | Wed Dec 1 | vsRichmond | L64-73 | 5-3 | .625 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 9 | Sun Dec 5 | vsKennesaw St | W88-62 | 6-3 | .667 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 10 | Wed Dec 8 | atGardner-Webb | W78-70 | 7-3 | .700 | - | | Paul Porter Arena · Boiling Springs, NC |
| 11 | Sun Dec 12 | atCoast Car | L59-60 | 7-4 | .636 | - | | The HTC Center · Conway, SC |
| 12 | Sat Dec 18 | atPresbyterian | W76-49 | 8-4 | .667 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 14 | Wed Dec 29 | vsVMI | L73-80 | 8-5 | .615 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 15 | Sat Jan 1 | atUNC Greensboro | PPD | 19-13 | .594 | - | | Greensboro Coliseum · Greensboro, NC |
| 16 | Wed Jan 5 | vsChattanooga | L67-75 | 8-6 | .571 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 17 | Sat Jan 8 | atETSU | W68-57 | 9-6 | .600 | - | | Freedom Hall Civic Center · Johnson City, TN |
| 18 | Mon Jan 10 | atUNC Greensboro | L54-58 | 9-7 | .563 | - | | Greensboro Coliseum · Greensboro, NC |
| 19 | Wed Jan 12 | vsSamford | W87-64 | 10-7 | .588 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 20 | Sat Jan 15 | atW Carolina | W84-64 | 11-7 | .611 | - | | Ramsey Regional Activity Center · Cullowhee, NC |
| 21 | Wed Jan 19 | vsThe Citadel | W89-77 | 12-7 | .632 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 22 | Sat Jan 22 | vsFurman | L50-75 | 12-8 | .600 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 23 | Wed Jan 26 | atChattanooga | L60-71 | 12-9 | .571 | - | | McKenzie Arena · Chattanooga, TN |
| 24 | Sat Jan 29 | vsUNC Greensboro | W85-66 | 13-9 | .591 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 25 | Mon Jan 31 | atMercer | L62-67 | 13-10 | .565 | - | ESPNU | Hawkins Arena · Macon, GA |
| 26 | Sat Feb 5 | vsETSU | W62-60 | 14-10 | .583 | - | CBSSN | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 27 | Wed Feb 9 | atSamford | L60-65 (OT) | 14-11 | .560 | - | | Pete Hanna Center · Homewood, AL |
| 28 | Sat Feb 12 | vsW Carolina | W69-57 | 15-11 | .577 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 29 | Wed Feb 16 | atThe Citadel | W65-58 | 16-11 | .593 | - | | McAlister Field House · Charleston, SC |
| 30 | Sat Feb 19 | atFurman | L69-70 | 16-12 | .571 | - | | Timmons Arena · Greenville, SC |
| 31 | Wed Feb 23 | atVMI | W83-72 | 17-12 | .586 | - | | Cameron Hall · Lexington, VA |
| 32 | Sat Feb 26 | vsMercer | W74-67 | 18-12 | .600 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 33 | Sat Mar 5 | vsVMI | W68-66 | 19-12 | .613 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 34 | Sun Mar 6 | atChattanooga | L56-79 | 19-13 | .594 | - | ESPNU | McKenzie Arena · Chattanooga, TN |
