| 1 | Tue Nov 5 | vs TBD | W86-63 | 1-0 | 1.000 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 2 | Sat Nov 9 | vs High Point | W89-61 | 2-0 | 1.000 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 3 | Tue Nov 12 | vs William & Mary | L79-80 | 2-1 | .667 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 4 | Sat Nov 16 | at Butler | L61-80 | 2-2 | .500 | - | FS2 | Hinkle Fieldhouse · Indianapolis, IN |
| 5 | Mon Nov 18 | at Missouri | L56-75 | 2-3 | .400 | - | | Mizzou Arena · Columbia, MO |
| 6 | Thu Nov 21 | at South Florida | L55-69 | 2-4 | .333 | - | | Yuengling Center · Tampa, FL |
| 7 | Tue Nov 26 | at MD-Eastern | W67-42 | 3-4 | .429 | - | | Hytche Athletic Center · Princess Anne, MD |
| 8 | Mon Dec 2 | vs NC Central | W77-59 | 4-4 | .500 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 9 | Sat Dec 7 | vs Gardner-Webb | W81-77 | 5-4 | .556 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 10 | Fri Dec 13 | vsTBD | W112-66 | 6-4 | .600 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 11 | Sun Dec 15 | at #17UNC | W68-64 | 7-4 | .636 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 12 | Thu Dec 19 | at #4Duke | L57-86 | 7-5 | .583 | - | ESPN2 | Cameron Indoor Stadium · Durham, NC |
| 13 | Sun Dec 22 | at Kennesaw St | W83-70 | 8-5 | .615 | - | | KSU Convocation Center · Kennesaw, GA |
| 14 | Wed Jan 1 | at ETSU | L48-49 | 8-6 | .571 | - | | Freedom Hall Civic Center · Johnson City, TN |
| 15 | Sat Jan 4 | vs UNC Greensboro | W98-92 (2OT) | 9-6 | .600 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 16 | Wed Jan 8 | at Samford | W67-62 | 10-6 | .625 | - | | Pete Hanna Center · Homewood, AL |
| 17 | Sat Jan 11 | vs The Citadel | W73-71 | 11-6 | .647 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 18 | Wed Jan 15 | at Chattanooga | L59-72 | 11-7 | .611 | - | | McKenzie Arena · Chattanooga, TN |
| 19 | Fri Jan 17 | vs Furman | W66-52 | 12-7 | .632 | - | ESPNU | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 20 | Wed Jan 22 | vs VMI | W66-54 | 13-7 | .650 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 21 | Sat Jan 25 | at W Carolina | L72-81 | 13-8 | .619 | - | | Ramsey Regional Activity Center · Cullowhee, NC |
| 22 | Wed Jan 29 | atThe Citadel | W79-56 | 14-8 | .636 | - | | McAlister Field House · Charleston, SC |
| 23 | Sat Feb 1 | vsSamford | W80-56 | 15-8 | .652 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 24 | Wed Feb 5 | atVMI | W79-73 | 16-8 | .667 | - | | Cameron Hall · Lexington, VA |
| 25 | Sat Feb 8 | vsChattanooga | L77-84 | 16-9 | .640 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 26 | Wed Feb 12 | vs Mercer | L68-70 | 16-10 | .615 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 27 | Sat Feb 15 | vsW Carolina | L74-80 | 16-11 | .593 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 28 | Wed Feb 19 | atUNC Greensboro | L79-83 (OT) | 16-12 | .571 | - | | Greensboro Coliseum · Greensboro, NC |
| 29 | Sat Feb 22 | atFurman | L66-67 | 16-13 | .552 | - | | Timmons Arena · Greenville, SC |
| 30 | Wed Feb 26 | vsETSU | L54-60 | 16-14 | .533 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 31 | Sat Feb 29 | atMercer | L47-59 | 16-15 | .516 | - | | Hawkins Arena · Macon, GA |
| 32 | Fri Mar 6 | vsThe Citadel | W93-76 | 17-15 | .531 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 33 | Sat Mar 7 | atFurman | W77-68 | 18-15 | .545 | - | | Timmons Arena · Greenville, SC |
| 34 | Sun Mar 8 | atChattanooga | W72-70 | 19-15 | .559 | - | | McKenzie Arena · Chattanooga, TN |
| 35 | Mon Mar 9 | atETSU | L58-72 | 19-16 | .543 | - | ESPN | Freedom Hall Civic Center · Johnson City, TN |
