| 1 | Mon Nov 4 | vs TBD | W72-51 | 1-0 | 1.000 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 2 | Fri Nov 8 | vs E Kentucky | L78-82 | 1-1 | .500 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 3 | Wed Nov 13 | vsTBD | W82-54 | 2-1 | .667 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 4 | Sat Nov 16 | at Davidson | L70-76 | 2-2 | .500 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 5 | Fri Nov 22 | vs SC Upstate | W87-76 | 3-2 | .600 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 6 | Sun Nov 24 | vs Queens | W82-67 | 4-2 | .667 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 7 | Wed Nov 27 | at Charlotte | W75-55 | 5-2 | .714 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 8 | Sat Nov 30 | vs Austin Peay | W79-57 | 6-2 | .750 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 9 | Tue Dec 3 | at JMU | L61-71 | 6-3 | .667 | - | ESPN+ | Atlantic Union Bank Center · Harrisonburg, VA |
| 10 | Sat Dec 7 | at Wichita St | L87-96 | 6-4 | .600 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 11 | Sat Dec 14 | at Jacksonville | L52-60 | 6-5 | .545 | - | ESPN+ | Swisher Gymnasium · Jacksonville, FL |
| 12 | Wed Dec 18 | vs Elon | W84-58 | 7-5 | .583 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 13 | Sat Dec 21 | at Kansas City | L66-73 | 7-6 | .538 | - | | Swinney Recreation Center · Kansas City, MO |
| 14 | Wed Jan 1 | vs VMI | W84-69 | 8-6 | .571 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 15 | Sat Jan 4 | vs Wofford | L78-81 | 8-7 | .533 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 16 | Wed Jan 8 | at Mercer | W70-68 | 9-7 | .563 | - | ESPN+ | Hawkins Arena · Macon, GA |
| 17 | Sat Jan 11 | vs The Citadel | W70-52 | 10-7 | .588 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 18 | Wed Jan 15 | at Furman | L70-73 | 10-8 | .556 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 19 | Sat Jan 18 | at Samford | W65-60 | 11-8 | .579 | - | CBS | Pete Hanna Center · Homewood, AL |
| 20 | Wed Jan 22 | vs W Carolina | W85-58 | 12-8 | .600 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 21 | Sat Jan 25 | vs Chattanooga | L63-71 | 12-9 | .571 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 22 | Wed Jan 29 | at UNC Greensboro | L65-70 | 12-10 | .545 | - | ESPN+ | Greensboro Coliseum · Greensboro, NC |
| 23 | Sun Feb 2 | vsFurman | W72-69 | 13-10 | .565 | - | CBS | Freedom Hall Civic Center · Johnson City, TN |
| 24 | Wed Feb 5 | atVMI | W62-55 | 14-10 | .583 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 25 | Sat Feb 8 | vsSamford | W66-59 | 15-10 | .600 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 26 | Wed Feb 12 | atW Carolina | L67-76 | 15-11 | .577 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 27 | Sat Feb 15 | atChattanooga | L71-78 | 15-12 | .556 | - | ESPN+ | McKenzie Arena · Chattanooga, TN |
| 28 | Wed Feb 19 | vsUNC Greensboro | W65-49 | 16-12 | .571 | - | ESPNU | Freedom Hall Civic Center · Johnson City, TN |
