| 1 | Tue Nov 4 | vs TBD | W102-50 | 1-0 | 1.000 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 2 | Sat Nov 8 | atPresbyterian | L64-68 | 1-1 | .500 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 3 | Wed Nov 12 | vsN Kentucky | W75-63 | 2-1 | .667 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 4 | Sat Nov 15 | atNorth Alabama | W78-74 | 3-1 | .750 | - | ESPN+ | Flowers Hall · Florence, AL |
| 5 | Fri Nov 21 | vsMorehead St | W77-62 | 4-1 | .800 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 6 | Sun Nov 23 | vsUL Monroe | W97-55 | 5-1 | .833 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 7 | Sat Nov 29 | vsC Arkansas | W80-57 | 6-1 | .857 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 8 | Tue Dec 2 | atDayton | L71-88 | 6-2 | .750 | - | ESPN+ | UD Arena · Dayton, OH |
| 9 | Fri Dec 5 | vsSouth Alabama | W91-65 | 7-2 | .778 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 10 | Sun Dec 7 | vsTBD | W78-62 | 8-2 | .800 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 11 | Fri Dec 12 | atAustin Peay | L75-76 | 8-3 | .727 | - | ESPN+ | Winfield Dunn Center · Clarksville, TN |
| 12 | Tue Dec 16 | at12UNC | L58-77 | 8-4 | .667 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 13 | Sat Dec 20 | vsJ'Ville St | L75-81 | 8-5 | .615 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 14 | Tue Dec 30 | atThe Citadel | W74-49 | 9-5 | .643 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 15 | Sat Jan 3 | vsMercer | W77-71 | 10-5 | .667 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 16 | Wed Jan 7 | vsVMI | W81-67 | 11-5 | .688 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 17 | Sat Jan 10 | vsUNC Greensboro | W86-60 | 12-5 | .706 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 18 | Wed Jan 14 | atW Carolina | L68-72 | 12-6 | .667 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 19 | Sat Jan 17 | atSamford | W76-75 | 13-6 | .684 | - | CBSSN | Pete Hanna Center · Homewood, AL |
| 20 | Wed Jan 21 | atChattanooga | W67-66 | 14-6 | .700 | - | ESPNU | McKenzie Arena · Chattanooga, TN |
| 21 | Fri Jan 23 | vsThe Citadel | W84-55 | 15-6 | .714 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 22 | Thu Jan 29 | vsW Carolina | L88-90 | 15-7 | .682 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 23 | Sun Feb 1 | atWofford | W86-72 | 16-7 | .696 | - | CBSSN | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 24 | Wed Feb 4 | vsFurman | W75-71 (OT) | 17-7 | .708 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 25 | Sat Feb 7 | atVMI | W87-70 | 18-7 | .720 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 26 | Wed Feb 11 | vsChattanooga | W73-61 | 19-7 | .731 | - | CBSSN | Freedom Hall Civic Center · Johnson City, TN |
| 27 | Sat Feb 14 | vsSamford | L72-82 (OT) | 19-8 | .704 | - | ESPNU | Freedom Hall Civic Center · Johnson City, TN |
| 28 | Wed Feb 18 | atFurman | W78-69 | 20-8 | .714 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 29 | Sat Feb 21 | atUNC Greensboro | W87-75 | 21-8 | .724 | - | ESPN+ | Greensboro Coliseum · Greensboro, NC |
| 30 | Wed Feb 25 | vsWofford | L69-72 | 21-9 | .700 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 31 | Sat Feb 28 | atMercer | L76-82 | 21-10 | .677 | - | ESPN+ | Hawkins Arena · Macon, GA |
