| 1 | Wed Nov 5 | vs So Indiana | TBD | 10-20 | .333 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 2 | Sat Nov 8 | vsIU Indy | 5:00 PM | 10-22 | .313 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 3 | Tue Nov 11 | vsChicago St | TBD | 4-28 | .125 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 4 | Sat Nov 15 | atSMU | TBD | 24-11 | .686 | - | The CW Network | Moody Coliseum · Dallas, TX |
| 5 | Fri Nov 21 | vsSouth Carolina | 2:00 PM | 12-20 | .375 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 6 | Sun Nov 23 | vsVirginia | 2:00 PM | 15-17 | .469 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 7 | Fri Nov 28 | vsWright St | TBD | 15-18 | .455 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 8 | Tue Dec 2 | vsE Michigan | TBD | 16-16 | .500 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 9 | Sat Dec 6 | vsBoise St | TBD | 26-11 | .703 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 10 | Sat Dec 13 | vsProvidence | TBD | 12-20 | .375 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 11 | Tue Dec 16 | at#4UConn | 8:30 PM | 24-11 | .686 | - | | Gampel Pavilion · Storrs, CT |
| 12 | Sat Dec 20 | vsNorthwestern | 4:00 PM | 17-16 | .515 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 13 | Mon Dec 22 | vsNJIT | 2:00 PM | 6-25 | .194 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 14 | Tue Dec 30 | at#23Creighton | TBD | 25-11 | .694 | - | | CHI Health Center Omaha · Omaha, NE |
| 15 | Sat Jan 3 | vsVillanova | TBD | 21-15 | .583 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 16 | Tue Jan 6 | vs#5St John's | TBD | 31-5 | .861 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 17 | Wed Jan 14 | atXavier | TBD | 22-12 | .647 | - | | Cintas Center · Cincinnati, OH |
| 18 | Sat Jan 17 | atSeton Hall | TBD | 7-25 | .219 | - | | Prudential Center · Newark, NJ |
| 19 | Tue Jan 20 | vsDePaul | TBD | 14-20 | .412 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 20 | Fri Jan 23 | vsMarquette | TBD | 23-11 | .676 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 21 | Wed Jan 28 | at#5St John's | TBD | 31-5 | .861 | - | | Carnesecca Arena · Queens, NY |
| 22 | Sat Jan 31 | vsGeorgetown | TBD | 18-16 | .529 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 23 | Wed Feb 4 | atProvidence | TBD | 12-20 | .375 | - | | Amica Mutual Pavilion · Providence, RI |
| 24 | Sat Feb 7 | atMarquette | TBD | 23-11 | .676 | - | | Fiserv Forum · Milwaukee, WI |
| 25 | Wed Feb 11 | vs#4UConn | 7:30 PM | 24-11 | .686 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 26 | Sun Feb 15 | vsSeton Hall | TBD | 7-25 | .219 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 27 | Wed Feb 18 | atGeorgetown | TBD | 18-16 | .529 | - | | Capital One Arena · Washington, D.C. |
| 28 | Sat Feb 21 | vsXavier | TBD | 22-12 | .647 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 29 | Wed Feb 25 | atVillanova | TBD | 21-15 | .583 | - | | Finneran Pavilion · Villanova, PA |
| 30 | Wed Mar 4 | vs#23Creighton | TBD | 25-11 | .694 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 31 | Sat Mar 7 | atDePaul | TBD | 14-20 | .412 | - | | Wintrust Arena · Chicago, IL |
