| 1 | Wed Nov 5 | vs So Indiana | W88-58 | 1-0 | 1.000 | - | ESPN+ | Hinkle Fieldhouse · Indianapolis, IN |
| 2 | Sat Nov 8 | vsIU Indy | W112-80 | 2-0 | 1.000 | - | ESPN+ | Hinkle Fieldhouse · Indianapolis, IN |
| 3 | Tue Nov 11 | vsChicago St | W98-66 | 3-0 | 1.000 | - | ESPN+ | Hinkle Fieldhouse · Indianapolis, IN |
| 4 | Sat Nov 15 | atSMU | L85-87 | 3-1 | .750 | - | The CW Network | Moody Coliseum · Dallas, TX |
| 5 | Fri Nov 21 | atSouth Carolina | W79-72 | 4-1 | .800 | - | CBSSN | Colonial Life Arena · Columbia, SC |
| 6 | Sun Nov 23 | atVirginia | W80-73 | 5-1 | .833 | - | CBSSN | John Paul Jones Arena · Charlottesville, VA |
| 7 | Fri Nov 28 | vsWright St | W94-69 | 6-1 | .857 | - | ESPN+ | Hinkle Fieldhouse · Indianapolis, IN |
| 8 | Tue Dec 2 | vsE Michigan | W84-68 | 7-1 | .875 | - | truTV | Hinkle Fieldhouse · Indianapolis, IN |
| 9 | Sat Dec 6 | vsBoise St | L68-77 | 7-2 | .778 | - | TNT | Hinkle Fieldhouse · Indianapolis, IN |
| 10 | Sat Dec 13 | vsProvidence | W113-110 (2OT) | 8-2 | .800 | - | TNT | Hinkle Fieldhouse · Indianapolis, IN |
| 11 | Tue Dec 16 | at5UConn | L60-79 | 8-3 | .727 | - | Peacock | Gampel Pavilion · Storrs, CT |
| 12 | Sat Dec 20 | vsNorthwestern | W61-58 | 9-3 | .750 | - | Peacock | Hinkle Fieldhouse · Indianapolis, IN |
| 13 | Mon Dec 22 | vsNJIT | W101-52 | 10-3 | .769 | - | ESPN+ | Hinkle Fieldhouse · Indianapolis, IN |
| 14 | Tue Dec 30 | atCreighton | L85-89 | 10-4 | .714 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 15 | Sat Jan 3 | vsVillanova | L67-85 | 10-5 | .667 | - | TNT | Hinkle Fieldhouse · Indianapolis, IN |
| 16 | Tue Jan 6 | vsSt John's | L70-84 | 10-6 | .625 | - | Peacock | Hinkle Fieldhouse · Indianapolis, IN |
| 17 | Wed Jan 14 | atXavier | L75-89 | 10-7 | .588 | - | FS1 | Cintas Center · Cincinnati, OH |
| 18 | Sat Jan 17 | at25Seton Hall | W77-66 | 11-7 | .611 | - | TNT | Prudential Center · Newark, NJ |
| 19 | Tue Jan 20 | vsDePaul | W87-80 | 12-7 | .632 | - | truTV | Hinkle Fieldhouse · Indianapolis, IN |
| 20 | Fri Jan 23 | vsMarquette | W87-76 | 13-7 | .650 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 21 | Wed Jan 28 | at25St John's | L70-92 | 13-8 | .619 | - | Peacock | Carnesecca Arena · Queens, NY |
| 22 | Sat Jan 31 | vsGeorgetown | L64-77 | 13-9 | .591 | - | TNT | Hinkle Fieldhouse · Indianapolis, IN |
| 23 | Wed Feb 4 | atProvidence | L87-97 (2OT) | 13-10 | .565 | - | Peacock | Amica Mutual Pavilion · Providence, RI |
| 24 | Sat Feb 7 | atMarquette | L55-70 | 13-11 | .542 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 25 | Wed Feb 11 | vs6UConn | L70-80 | 13-12 | .520 | - | TNT | Hinkle Fieldhouse · Indianapolis, IN |
| 26 | Sun Feb 15 | vsSeton Hall | L56-63 | 13-13 | .500 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 27 | Wed Feb 18 | atGeorgetown | W93-89 | 14-13 | .519 | - | FS1 | Capital One Arena · Washington, D.C. |
| 28 | Sat Feb 21 | vsXavier | W80-75 | 15-13 | .536 | - | TNT | Hinkle Fieldhouse · Indianapolis, IN |
| 29 | Wed Feb 25 | atVillanova | L73-82 | 15-14 | .517 | - | FS1 | Finneran Pavilion · Villanova, PA |
