| 1 | Wed Nov 25 | vs W Michigan | W66-62 | 1-0 | 1.000 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 4 | Mon Dec 14 | vsSt John's | PPD | 10-15 | .400 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 5 | Wed Dec 16 | at7Villanova | L66-85 | 1-1 | .500 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 6 | Sat Dec 19 | atIndiana | L60-68 | 1-2 | .333 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 7 | Mon Dec 21 | vsS Illinois | L73-76 | 1-3 | .250 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 8 | Wed Dec 23 | vsProvidence | W70-64 | 2-3 | .400 | - | CBSSN | Hinkle Fieldhouse · Indianapolis, IN |
| 9 | Wed Dec 30 | atProvidence | L55-71 | 2-4 | .333 | - | FS1 | Amica Mutual Pavilion · Providence, RI |
| 10 | Sat Jan 2 | atSeton Hall | L60-68 | 2-5 | .286 | - | FS1 | Prudential Center · Newark, NJ |
| 11 | Wed Jan 6 | vsGeorgetown | W63-55 | 3-5 | .375 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 12 | Sat Jan 9 | vsUConn | L60-72 | 3-6 | .333 | - | CBSSN | Hinkle Fieldhouse · Indianapolis, IN |
| 13 | Tue Jan 12 | atSt John's | L57-69 | 3-7 | .300 | - | FS1 | Carnesecca Arena · Queens, NY |
| 14 | Sat Jan 16 | vs8Creighton | W70-66 (OT) | 4-7 | .364 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 15 | Tue Jan 19 | atDePaul | W67-53 | 5-7 | .417 | - | CBSSN | Wintrust Arena · Chicago, IL |
| 16 | Fri Jan 22 | vsSeton Hall | PPD | 10-15 | .400 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 17 | Tue Jan 26 | atUConn | L51-63 | 5-8 | .385 | - | FS1 | Gampel Pavilion · Storrs, CT |
| 18 | Fri Jan 29 | vsXavier | PPD | 10-15 | .400 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 19 | Sat Jan 30 | vsXavier | L55-68 | 5-9 | .357 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 20 | Tue Feb 2 | atMarquette | L67-70 | 5-10 | .333 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 21 | Sat Feb 6 | vsDePaul | W68-58 | 6-10 | .375 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 22 | Tue Feb 9 | vsSt John's | W76-73 (OT) | 7-10 | .412 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 23 | Sat Feb 13 | atGeorgetown | L63-78 | 7-11 | .389 | - | CBSSN | Capital One Arena · Washington, D.C. |
| 24 | Wed Feb 17 | vsMarquette | L57-73 | 7-12 | .368 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 25 | Sun Feb 21 | atXavier | L51-63 | 7-13 | .350 | - | | Cintas Center · Cincinnati, OH |
| 26 | Wed Feb 24 | vsSeton Hall | W61-52 | 8-13 | .381 | - | CBSSN | Hinkle Fieldhouse · Indianapolis, IN |
| 27 | Sun Feb 28 | vs8Villanova | W73-61 | 9-13 | .409 | - | CBS | Hinkle Fieldhouse · Indianapolis, IN |
| 28 | Sat Mar 6 | atCreighton | L73-93 | 9-14 | .391 | - | FOX | CHI Health Center Omaha · Omaha, NE |
| 29 | Wed Mar 10 | atXavier | W70-69 (OT) | 10-14 | .417 | - | FS1 | Cintas Center · Cincinnati, OH |
| 30 | Thu Mar 11 | atCreighton | L56-87 | 10-15 | .400 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
