| 1 | Tue Nov 9 | vs IU Indy | W56-47 | 1-0 | 1.000 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 2 | Fri Nov 12 | vs C Arkansas | W85-53 | 2-0 | 1.000 | - | FS2 | Hinkle Fieldhouse · Indianapolis, IN |
| 3 | Sat Nov 13 | vs Troy | W70-59 | 3-0 | 1.000 | - | FS2 | Hinkle Fieldhouse · Indianapolis, IN |
| 4 | Wed Nov 17 | vs Michigan St | L52-73 | 3-1 | .750 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 5 | Mon Nov 22 | at Houston | L52-70 | 3-2 | .600 | - | ESPN2 | Fertitta Center · Houston, TX |
| 6 | Tue Nov 23 | vs Texas A&M | L50-57 | 3-3 | .500 | - | ESPN2 | Hinkle Fieldhouse · Indianapolis, IN |
| 7 | Wed Nov 24 | at TBD | W84-51 | 4-3 | .571 | - | ESPNU | Michelob ULTRA Arena |
| 8 | Tue Nov 30 | vsTBD | W68-57 | 5-3 | .625 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 9 | Tue Dec 7 | at Oklahoma | W66-62 (OT) | 6-3 | .667 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 10 | Sat Dec 11 | vs E Illinois | W66-54 | 7-3 | .700 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 11 | Sat Dec 18 | vs Purdue | L48-77 | 7-4 | .636 | - | FOX | Hinkle Fieldhouse · Indianapolis, IN |
| 12 | Thu Dec 23 | at St John's | PPD | 14-19 | .424 | - | | Carnesecca Arena · Queens, NY |
| 13 | Wed Dec 29 | vs DePaul | W63-59 | 8-4 | .667 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 14 | Sat Jan 1 | at UConn | PPD | 14-19 | .424 | - | | Gampel Pavilion · Storrs, CT |
| 15 | Tue Jan 4 | vs #24Seton Hall | L56-71 | 8-5 | .615 | - | CBS | Hinkle Fieldhouse · Indianapolis, IN |
| 16 | Fri Jan 7 | vs #22Xavier | L72-87 | 8-6 | .571 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 17 | Thu Jan 13 | at Georgetown | W72-58 | 9-6 | .600 | - | FS1 | Capital One Arena · Washington, D.C. |
| 18 | Sun Jan 16 | at #14Villanova | L42-82 | 9-7 | .563 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 19 | Tue Jan 18 | at#25UConn | L59-76 | 9-8 | .529 | - | FS1 | Gampel Pavilion · Storrs, CT |
| 20 | Thu Jan 20 | vs#25UConn | L56-75 | 9-9 | .500 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 21 | Sun Jan 23 | at #21Providence | L62-69 | 9-10 | .474 | - | FS1 | Amica Mutual Pavilion · Providence, RI |
| 22 | Wed Jan 26 | vs Creighton | W72-55 | 10-10 | .500 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 23 | Sat Jan 29 | vsGeorgetown | W56-53 | 11-10 | .524 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 24 | Wed Feb 2 | at#21Xavier | L66-68 | 11-11 | .500 | - | CBS | Cintas Center · Cincinnati, OH |
| 25 | Sat Feb 5 | vsSt John's | L72-75 | 11-12 | .478 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 26 | Tue Feb 8 | atCreighton | L52-54 | 11-13 | .458 | - | CBS | CHI Health Center Omaha · Omaha, NE |
| 27 | Sat Feb 12 | vs #18Marquette | W85-79 | 12-13 | .480 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 28 | Tue Feb 15 | atDePaul | W73-71 | 13-13 | .500 | - | FS1 | Wintrust Arena · Chicago, IL |
| 29 | Fri Feb 18 | atSt John's | L57-91 | 13-14 | .481 | - | CBS | Carnesecca Arena · Queens, NY |
| 30 | Sun Feb 20 | vs#8Providence | L70-71 (OT) | 13-15 | .464 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 31 | Wed Feb 23 | atSeton Hall | L60-66 | 13-16 | .448 | - | FS1 | Prudential Center · Newark, NJ |
| 32 | Sat Feb 26 | atMarquette | L56-64 | 13-17 | .433 | - | FOX | Fiserv Forum · Milwaukee, WI |
| 33 | Sat Mar 5 | vs#11Villanova | L59-78 | 13-18 | .419 | - | FOX | Hinkle Fieldhouse · Indianapolis, IN |
| 34 | Wed Mar 9 | atXavier | W89-82 (OT) | 14-18 | .438 | - | FS1 | Cintas Center · Cincinnati, OH |
| 35 | Thu Mar 10 | atProvidence | L61-65 | 14-19 | .424 | - | FS1 | Amica Mutual Pavilion · Providence, RI |
