| 1 | Wed Nov 6 | vs IU Indy | W80-47 | 1-0 | 1.000 | - | FS2 | Hinkle Fieldhouse · Indianapolis, IN |
| 2 | Sat Nov 9 | vsNew Orleans | W79-53 | 2-0 | 1.000 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 3 | Tue Nov 12 | vsMinnesota | W64-56 | 3-0 | 1.000 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 4 | Sat Nov 16 | vsWofford | W80-61 | 4-0 | 1.000 | - | FS2 | Hinkle Fieldhouse · Indianapolis, IN |
| 5 | Fri Nov 22 | vsMorehead St | W68-50 | 5-0 | 1.000 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 6 | Mon Nov 25 | atMissouri | W63-52 | 6-0 | 1.000 | - | ESPNU | T-Mobile Center · Kansas City, MOS |
| 7 | Tue Nov 26 | vsStanford | W68-67 | 7-0 | 1.000 | - | ESPN2 | T-Mobile Center · Kansas City, MOS |
| 8 | Tue Dec 3 | atOle Miss | W67-58 | 8-0 | 1.000 | #24 | SEC Network | SJB Pavilion · Oxford, MS |
| 9 | Sat Dec 7 | vsFlorida | W76-62 | 9-0 | 1.000 | #24 | FOX | Hinkle Fieldhouse · Indianapolis, IN |
| 10 | Tue Dec 10 | at11Baylor | L52-53 | 9-1 | .900 | #18 | ESPN2 | Ferrell Center · Waco, TX |
| 11 | Sat Dec 14 | vsSouthern | W66-41 | 10-1 | .909 | #18 | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 12 | Sat Dec 21 | atPurdue | W70-61 | 11-1 | .917 | - | BTN | Mackey Arena · West Lafayette, IN |
| 13 | Sat Dec 28 | vsUL Monroe | W67-36 | 12-1 | .923 | #12 | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 14 | Tue Dec 31 | atSt John's | W60-58 | 13-1 | .929 | #11 | FS1 | Carnesecca Arena · Queens, NY |
| 15 | Sat Jan 4 | vsCreighton | W71-57 | 14-1 | .933 | #11 | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 16 | Fri Jan 10 | atProvidence | W70-58 | 15-1 | .938 | #6 | FS1 | Amica Mutual Pavilion · Providence, RI |
| 17 | Wed Jan 15 | vs18Seton Hall | L70-78 | 15-2 | .882 | #5 | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 18 | Sat Jan 18 | atDePaul | L66-79 | 15-3 | .833 | #5 | | Wintrust Arena · Chicago, IL |
| 19 | Tue Jan 21 | at9Villanova | L61-76 | 15-4 | .789 | #13 | CBSSN | Finneran Pavilion · Villanova, PA |
| 20 | Fri Jan 24 | vsMarquette | W89-85 (OT) | 16-4 | .800 | #13 | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 21 | Tue Jan 28 | atGeorgetown | W69-64 | 17-4 | .810 | #16 | CBSSN | Capital One Arena · Washington, D.C. |
| 22 | Sat Feb 1 | vsProvidence | L61-65 | 17-5 | .773 | #16 | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 23 | Wed Feb 5 | vs10Villanova | W79-76 | 18-5 | .783 | #19 | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 24 | Sun Feb 9 | atMarquette | L57-76 | 18-6 | .750 | #19 | FS1 | Fiserv Forum · Milwaukee, WI |
| 25 | Wed Feb 12 | vsXavier | W66-61 | 19-6 | .760 | #19 | CBSSN | Hinkle Fieldhouse · Indianapolis, IN |
| 26 | Sat Feb 15 | vsGeorgetown | L66-73 | 19-7 | .731 | #19 | FOX | Hinkle Fieldhouse · Indianapolis, IN |
| 27 | Wed Feb 19 | at16Seton Hall | L72-74 | 19-8 | .704 | #21 | FS1 | Prudential Center · Newark, NJ |
| 28 | Sun Feb 23 | at15Creighton | L59-81 | 19-9 | .679 | #21 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 29 | Sat Feb 29 | vsDePaul | W60-42 | 20-9 | .690 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 30 | Wed Mar 4 | vsSt John's | W77-55 | 21-9 | .700 | - | CBSSN | Hinkle Fieldhouse · Indianapolis, IN |
| 31 | Sat Mar 7 | atXavier | W72-71 | 22-9 | .710 | - | FS1 | Cintas Center · Cincinnati, OH |
