| 1 | Mon Nov 7 | vs New Orleans | W89-53 | 1-0 | 1.000 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 2 | Mon Nov 14 | at Penn State | L62-68 | 1-1 | .500 | - | FS1 | Bryce Jordan Center · University Park, PA |
| 3 | Thu Nov 17 | vs St Francis PA | W95-67 | 2-1 | .667 | - | FS2 | Hinkle Fieldhouse · Indianapolis, IN |
| 4 | Sat Nov 19 | vs The Citadel | W89-42 | 3-1 | .750 | - | FS2 | Hinkle Fieldhouse · Indianapolis, IN |
| 5 | Wed Nov 23 | at Tennessee | L45-71 | 3-2 | .600 | - | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
| 6 | Thu Nov 24 | at BYU | W75-70 | 4-2 | .667 | - | | Marriott Center · Provo, UT |
| 7 | Fri Nov 25 | at NC State | L61-76 | 4-3 | .571 | - | ESPN2 | PNC Arena · Raleigh, NC |
| 8 | Wed Nov 30 | vs Kansas St | W76-64 | 5-3 | .625 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 9 | Sat Dec 3 | vs Tennessee Tech | W80-66 | 6-3 | .667 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 10 | Tue Dec 6 | vs Yale | W71-61 | 7-3 | .700 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 11 | Sat Dec 10 | at California | W82-58 | 8-3 | .727 | - | PACN | Haas Pavilion · Berkeley, CA |
| 12 | Sat Dec 17 | vs #3UConn | L46-68 | 8-4 | .667 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 13 | Thu Dec 22 | at Creighton | L56-78 | 8-5 | .615 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 14 | Thu Dec 29 | vs Providence | L52-72 | 8-6 | .571 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 15 | Sun Jan 1 | at Georgetown | W80-51 | 9-6 | .600 | - | FS1 | Capital One Arena · Washington, D.C. |
| 16 | Wed Jan 4 | vs DePaul | W78-70 | 10-6 | .625 | - | CBS | Hinkle Fieldhouse · Indianapolis, IN |
| 17 | Sat Jan 7 | at Seton Hall | L51-76 | 10-7 | .588 | - | FS1 | Prudential Center · Newark, NJ |
| 18 | Tue Jan 10 | at St John's | L61-77 | 10-8 | .556 | - | FS1 | Carnesecca Arena · Queens, NY |
| 19 | Fri Jan 13 | vs Villanova | W79-71 | 11-8 | .579 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 20 | Tue Jan 17 | vsCreighton | L52-73 | 11-9 | .550 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 21 | Sun Jan 22 | at#15UConn | L56-86 | 11-10 | .524 | - | FOX | Gampel Pavilion · Storrs, CT |
| 22 | Wed Jan 25 | at#23Providence | L58-79 | 11-11 | .500 | - | FS1 | Amica Mutual Pavilion · Providence, RI |
| 23 | Sat Jan 28 | vsSeton Hall | L49-70 | 11-12 | .478 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 24 | Sat Feb 4 | at #14Marquette | L52-60 | 11-13 | .458 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 25 | Tue Feb 7 | vsSt John's | W68-66 | 12-13 | .480 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 26 | Fri Feb 10 | vs #13Xavier | W69-67 | 13-13 | .500 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 27 | Tue Feb 14 | atVillanova | L50-62 | 13-14 | .481 | - | CBS | Finneran Pavilion · Villanova, PA |
| 28 | Sun Feb 19 | vsGeorgetown | L62-68 | 13-15 | .464 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 29 | Wed Feb 22 | atDePaul | W59-58 | 14-15 | .483 | - | FS1 | Wintrust Arena · Chicago, IL |
| 30 | Tue Feb 28 | vs#6Marquette | L56-72 | 14-16 | .467 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 31 | Sat Mar 4 | at#19Xavier | L66-78 | 14-17 | .452 | - | FS1 | Cintas Center · Cincinnati, OH |
| 32 | Wed Mar 8 | atSt John's | L63-76 | 14-18 | .438 | - | FS1 | Carnesecca Arena · Queens, NY |
