| 1 | Mon Nov 4 | vs Quinnipiac | W88-62 | 1-0 | 1.000 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 2 | Fri Nov 8 | at UIC | L79-91 | 1-1 | .500 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 3 | Mon Nov 11 | at #13Purdue | L84-92 | 1-2 | .333 | - | BTN | Mackey Arena · West Lafayette, IN |
| 4 | Wed Nov 13 | vs TBD | W100-46 | 2-2 | .500 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 5 | Sat Nov 16 | at Minnesota | L56-59 | 2-3 | .400 | - | BTN | Williams Arena · Minneapolis, MN |
| 6 | Wed Nov 20 | at Stony Brook | W86-64 | 3-3 | .500 | - | FloSports | Island FCU Arena · Stony Brook, NY |
| 7 | Sat Nov 23 | vs Fairfield | W91-66 | 4-3 | .571 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 8 | Sun Nov 24 | at Delaware | L94-100 | 4-4 | .500 | - | ESPNU | Bob Carpenter Center · Newark, DE |
| 9 | Mon Dec 2 | at Rhode Island | L78-84 | 4-5 | .444 | - | ESPN+ | Ryan Center · Kingston, RI |
| 10 | Sat Dec 7 | vs Vermont | W65-50 | 5-5 | .500 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 11 | Fri Dec 20 | vs Akron | W74-58 | 6-5 | .545 | - | | John J. Lee Amphitheater · New Haven, CT |
| 12 | Sat Dec 21 | at UTEP | L74-75 | 6-6 | .500 | - | | Don Haskins Center · El Paso, TX |
| 13 | Wed Jan 1 | vs Howard | W93-65 | 7-6 | .538 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 14 | Sat Jan 11 | vs Brown | W79-58 | 8-6 | .571 | - | ESPNU | John J. Lee Amphitheater · New Haven, CT |
| 15 | Sat Jan 18 | at Columbia | W92-88 | 9-6 | .600 | - | ESPN+ | Francis S. Levien Gymnasium · New York, NY |
| 16 | Mon Jan 20 | vs Dartmouth | W83-67 | 10-6 | .625 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 17 | Sat Jan 25 | vs Harvard | W84-55 | 11-6 | .647 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 18 | Fri Jan 31 | at Princeton | W77-70 | 12-6 | .667 | - | ESPN2 | Jadwin Gymnasium · Princeton, NJ |
| 19 | Sat Feb 1 | at Penn | W90-61 | 13-6 | .684 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 20 | Sat Feb 8 | at Cornell | W103-88 | 14-6 | .700 | - | ESPN+ | Newman Arena · Ithaca, NY |
| 21 | Fri Feb 14 | vsPenn | W72-71 | 15-6 | .714 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 22 | Sat Feb 15 | vsPrinceton | W84-57 | 16-6 | .727 | - | ESPNU | John J. Lee Amphitheater · New Haven, CT |
