| 1 | Fri Nov 7 | at Navy | W97-68 | 1-0 | 1.000 | - | CBSSN | Alumni Hall (Navy) · Annapolis, MD |
| 2 | Tue Nov 11 | atQuinnipiac | W97-60 | 2-0 | 1.000 | - | ESPN+ | M&T Bank Arena · Hamden, CT |
| 3 | Sat Nov 15 | vsStony Brook | W86-79 | 3-0 | 1.000 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 4 | Tue Nov 18 | vsRhode Island | L77-86 | 3-1 | .750 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 5 | Fri Nov 21 | vsGreen Bay | W73-67 | 4-1 | .800 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 6 | Sun Nov 23 | atCharleston | W74-63 | 5-1 | .833 | - | ESPN+ | TD Arena · Charleston, SC |
| 7 | Mon Nov 24 | atAkron | W97-94 | 6-1 | .857 | - | | James A. Rhodes Arena · Akron, OH |
| 8 | Sun Nov 30 | atVermont | W77-74 | 7-1 | .875 | - | ESPN+ | Patrick Gymnasium · Burlington, VT |
| 9 | Tue Dec 2 | vsTBD | W117-53 | 8-1 | .889 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 10 | Wed Dec 3 | vsTBD | W79-61 | 9-1 | .900 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 11 | Sun Dec 7 | vsUIC | W80-66 | 10-1 | .909 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 12 | Wed Dec 10 | vsAlbany | W93-82 | 11-1 | .917 | - | ESPNU | John J. Lee Amphitheater · New Haven, CT |
| 13 | Mon Dec 29 | at14Alabama | L78-102 | 11-2 | .846 | - | SECN+ | Coleman Coliseum · Tuscaloosa, AL |
| 14 | Mon Jan 5 | atBrown | W70-53 | 12-2 | .857 | - | ESPN+ | Pizzitola Sports Center · Providence, RI |
| 15 | Sat Jan 10 | atPrinceton | L60-76 | 12-3 | .800 | - | ESPN+ | Jadwin Gymnasium · Princeton, NJ |
| 16 | Sat Jan 17 | vsCornell | W102-68 | 13-3 | .813 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 17 | Mon Jan 19 | vsColumbia | W91-74 | 14-3 | .824 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 18 | Sat Jan 24 | atPenn | W77-60 | 15-3 | .833 | - | ESPNU | The Palestra · Philadelphia, PA |
| 19 | Fri Jan 30 | vsDartmouth | W83-68 | 16-3 | .842 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 20 | Sat Jan 31 | vsHarvard | L65-67 | 16-4 | .800 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 21 | Fri Feb 6 | vsBrown | W81-69 | 17-4 | .810 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 22 | Mon Feb 9 | atHoward | W87-81 (OT) | 18-4 | .818 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 23 | Fri Feb 13 | atDartmouth | W83-70 | 19-4 | .826 | - | ESPN+ | Edward Leede Arena · Hanover, NH |
| 24 | Sat Feb 14 | atHarvard | W76-75 (OT) | 20-4 | .833 | - | ESPNU | Lavietes Pavilion · Cambridge, MA |
| 25 | Sat Feb 21 | vsPenn | W74-70 | 21-4 | .840 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 26 | Fri Feb 27 | atCornell | L69-72 | 21-5 | .808 | - | ESPNU | Newman Arena · Ithaca, NY |
| 27 | Sat Feb 28 | atColumbia | W60-54 | 22-5 | .815 | - | ESPN+ | Francis S. Levien Gymnasium · New York, NY |
