| 1 | Mon Nov 7 | vs TBD | W96-41 | 1-0 | 1.000 | - | | John J. Lee Amphitheater · New Haven, CT |
| 2 | Fri Nov 11 | atE Washington | W74-60 | 2-0 | 1.000 | - | | Reese Court · Cheney, WA |
| 3 | Sun Nov 13 | vsMiss Valley St | W80-51 | 3-0 | 1.000 | - | | John J. Lee Amphitheater · New Haven, CT |
| 4 | Mon Nov 14 | atHawai'i | W62-59 (OT) | 4-0 | 1.000 | - | | Stan Sheriff Center · Honolulu, HI |
| 5 | Sun Nov 20 | vsTBD | W112-55 | 5-0 | 1.000 | - | | John J. Lee Amphitheater · New Haven, CT |
| 6 | Tue Nov 22 | vsVermont | W73-44 | 6-0 | 1.000 | - | | John J. Lee Amphitheater · New Haven, CT |
| 7 | Sun Nov 27 | atColorado | L62-65 | 6-1 | .857 | - | PACN | CU Events Center · Boulder, CO |
| 8 | Wed Nov 30 | vsHoward | W86-40 | 7-1 | .875 | - | | John J. Lee Amphitheater · New Haven, CT |
| 9 | Sat Dec 3 | atStony Brook | W77-72 | 8-1 | .889 | - | | Island FCU Arena · Stony Brook, NY |
| 10 | Tue Dec 6 | atButler | L61-71 | 8-2 | .800 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 11 | Sat Dec 10 | at#16Kentucky | L59-69 | 8-3 | .727 | - | SEC Network | Rupp Arena · Lexington, KY |
| 12 | Mon Dec 12 | atFairfield | W77-64 | 9-3 | .750 | - | | Leo D. Mahoney Arena · Fairfield, CT |
| 13 | Thu Dec 22 | atMonmouth | W76-44 | 10-3 | .769 | - | | OceanFirst Bank Center · West Long Branch, NJ |
| 14 | Sat Dec 31 | atColumbia | L60-62 | 10-4 | .714 | - | | Francis S. Levien Gymnasium · New York, NY |
| 15 | Fri Jan 6 | vsDartmouth | L77-81 | 10-5 | .667 | - | | John J. Lee Amphitheater · New Haven, CT |
| 16 | Sat Jan 7 | vsHarvard | W58-54 | 11-5 | .688 | - | | John J. Lee Amphitheater · New Haven, CT |
| 17 | Fri Jan 13 | atCornell | L82-94 | 11-6 | .647 | - | ESPNU | Newman Arena · Ithaca, NY |
| 18 | Mon Jan 16 | vsBrown | W81-78 | 12-6 | .667 | - | | John J. Lee Amphitheater · New Haven, CT |
| 19 | Sat Jan 21 | vsPenn | W70-63 | 13-6 | .684 | - | | John J. Lee Amphitheater · New Haven, CT |
| 20 | Sat Jan 28 | vsPrinceton | W87-65 | 14-6 | .700 | - | | John J. Lee Amphitheater · New Haven, CT |
| 21 | Fri Feb 3 | atHarvard | W68-57 | 15-6 | .714 | - | ESPNU | Lavietes Pavilion · Cambridge, MA |
| 22 | Sat Feb 4 | atDartmouth | W72-53 | 16-6 | .727 | - | | Edward Leede Arena · Hanover, NH |
| 23 | Sat Feb 11 | vsColumbia | W99-68 | 17-6 | .739 | - | | John J. Lee Amphitheater · New Haven, CT |
| 24 | Fri Feb 17 | atPenn | L64-66 | 17-7 | .708 | - | ESPNEWS | The Palestra · Philadelphia, PA |
| 25 | Sat Feb 18 | atPrinceton | W93-83 (OT) | 18-7 | .720 | - | | Jadwin Gymnasium · Princeton, NJ |
| 26 | Sat Feb 25 | vsCornell | W76-58 | 19-7 | .731 | - | | John J. Lee Amphitheater · New Haven, CT |
| 27 | Sat Mar 4 | atBrown | W84-75 | 20-7 | .741 | - | | Pizzitola Sports Center · Providence, RI |
| 28 | Sat Mar 11 | vsCornell | W80-60 | 21-7 | .750 | - | ESPNU | John J. Lee Amphitheater · New Haven, CT |
| 29 | Sun Mar 12 | vsPrinceton | L65-74 | 21-8 | .724 | - | ESPN2 | John J. Lee Amphitheater · New Haven, CT |
| 30 | Tue Mar 14 | atVanderbilt | L62-71 | 21-9 | .700 | - | ESPNU | Memorial Gymnasium (TN) · Nashville, TN |
