| 1 | Fri Nov 7 | vs TBD | W79-50 | 1-0 | 1.000 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 2 | Sun Nov 9 | vsNew Hampshire | W86-75 | 2-0 | 1.000 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 3 | Tue Nov 11 | vsNortheastern | L60-77 | 2-1 | .667 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 4 | Sat Nov 15 | atArmy | W75-52 | 3-1 | .750 | - | ESPN+ | Christl Arena · West Point, NY |
| 5 | Sun Nov 16 | atMarist | W56-54 | 4-1 | .800 | - | ESPN+ | McCann Arena · Poughkeepsie, NY |
| 6 | Wed Nov 19 | atPenn State | L80-84 | 4-2 | .667 | - | B1G+ | Bryce Jordan Center · University Park, PA |
| 7 | Sat Nov 22 | atBoston Univ | L74-75 | 4-3 | .571 | - | | Case Gym · Boston, MA |
| 8 | Wed Nov 26 | atBoston College | L60-73 | 4-4 | .500 | - | ACC Extra | Silvio O. Conte Forum · Chestnut Hill, MA |
| 9 | Sat Nov 29 | vsBryant | W56-53 | 5-4 | .556 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 10 | Wed Dec 3 | atUMass | L71-78 | 5-5 | .500 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 11 | Sat Dec 6 | atFurman | L69-79 | 5-6 | .455 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 12 | Sat Dec 20 | vsHoly Cross | W81-53 | 6-6 | .500 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 13 | Tue Dec 23 | atSt John's | L59-85 | 6-7 | .462 | - | FS1 | Carnesecca Arena · Queens, NY |
| 14 | Sun Dec 28 | atColgate | W78-69 | 7-7 | .500 | - | ESPN+ | Cotterell Court · Hamilton, NY |
| 15 | Mon Jan 5 | vsDartmouth | L68-76 | 7-8 | .467 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 16 | Sat Jan 10 | atColumbia | W79-54 | 8-8 | .500 | - | ESPN+ | Francis S. Levien Gymnasium · New York, NY |
| 17 | Sat Jan 17 | vsPrinceton | W87-80 (OT) | 9-8 | .529 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 18 | Mon Jan 19 | vsPenn | W64-63 | 10-8 | .556 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 19 | Sat Jan 24 | vsCornell | L79-86 | 10-9 | .526 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 20 | Fri Jan 30 | atBrown | W69-59 | 11-9 | .550 | - | ESPN+ | Pizzitola Sports Center · Providence, RI |
| 21 | Sat Jan 31 | atYale | W67-65 | 12-9 | .571 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 22 | Sat Feb 7 | atDartmouth | W71-58 | 13-9 | .591 | - | ESPN+ | Edward Leede Arena · Hanover, NH |
| 23 | Fri Feb 13 | vsBrown | W56-53 | 14-9 | .609 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 24 | Sat Feb 14 | vsYale | L75-76 (OT) | 14-10 | .583 | - | ESPNU | Lavietes Pavilion · Cambridge, MA |
| 25 | Sat Feb 21 | atCornell | W73-54 | 15-10 | .600 | - | ESPN+ | Newman Arena · Ithaca, NY |
| 26 | Fri Feb 27 | atPrinceton | W58-56 | 16-10 | .615 | - | ESPN+ | Jadwin Gymnasium · Princeton, NJ |
| 27 | Sat Feb 28 | atPenn | L61-64 | 16-11 | .593 | - | ESPN+ | The Palestra · Philadelphia, PA |
