| 1 | Tue Nov 9 | vs TBD | W86-70 | 1-0 | 1.000 | - | | Lavietes Pavilion · Cambridge, MA |
| 2 | Sat Nov 13 | at Iona | L87-90 (OT) | 1-1 | .500 | - | | Hynes Athletics Center · New Rochelle, NY |
| 3 | Wed Nov 17 | at Albany | W60-53 | 2-1 | .667 | - | | SEFCU Arena · Albany, NY |
| 4 | Sat Nov 20 | vsTBD | W98-52 | 3-1 | .750 | - | | Lavietes Pavilion · Cambridge, MA |
| 5 | Mon Nov 22 | at Siena | L69-72 | 3-2 | .600 | - | | MVP Arena · Albany, NY |
| 6 | Wed Nov 24 | vs Colgate | W89-84 (OT) | 4-2 | .667 | - | | Lavietes Pavilion · Cambridge, MA |
| 7 | Sat Nov 27 | vs Northeastern | W77-57 | 5-2 | .714 | - | | Lavietes Pavilion · Cambridge, MA |
| 8 | Wed Dec 1 | vs Rhode Island | L57-64 | 5-3 | .625 | - | | Lavietes Pavilion · Cambridge, MA |
| 9 | Sat Dec 4 | at UMass | L77-87 | 5-4 | .556 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 10 | Mon Dec 6 | vsTBD | W74-64 | 6-4 | .600 | - | | Lavietes Pavilion · Cambridge, MA |
| 11 | Sun Dec 19 | vs Holy Cross | W62-54 | 7-4 | .636 | - | | Lavietes Pavilion · Cambridge, MA |
| 12 | Tue Dec 21 | vs Howard | W77-69 | 8-4 | .667 | - | | Lavietes Pavilion · Cambridge, MA |
| 13 | Sun Jan 2 | vs Princeton | PPD | 13-13 | .500 | - | | Lavietes Pavilion · Cambridge, MA |
| 14 | Fri Jan 7 | vs Brown | L73-84 | 8-5 | .615 | - | ESPNU | Lavietes Pavilion · Cambridge, MA |
| 15 | Sun Jan 9 | vs Yale | PPD | 13-13 | .500 | - | | Lavietes Pavilion · Cambridge, MA |
| 16 | Sat Jan 15 | at Columbia | W91-82 | 9-5 | .643 | - | | Francis S. Levien Gymnasium · New York, NY |
| 17 | Mon Jan 17 | at Dartmouth | W60-59 | 10-5 | .667 | - | | Edward Leede Arena · Hanover, NH |
| 18 | Sat Jan 22 | at Cornell | L61-76 | 10-6 | .625 | - | | Newman Arena · Ithaca, NY |
| 19 | Fri Jan 28 | vs Penn | L74-78 | 10-7 | .588 | - | ESPNU | Lavietes Pavilion · Cambridge, MA |
| 20 | Fri Feb 4 | atBrown | W65-50 | 11-7 | .611 | - | | Pizzitola Sports Center · Providence, RI |
| 21 | Sat Feb 5 | atYale | L55-58 | 11-8 | .579 | - | | John J. Lee Amphitheater · New Haven, CT |
| 22 | Wed Feb 9 | vsYale | L59-62 | 11-9 | .550 | - | | Lavietes Pavilion · Cambridge, MA |
| 23 | Sat Feb 12 | atPenn | L74-82 | 11-10 | .524 | - | | The Palestra · Philadelphia, PA |
| 24 | Fri Feb 18 | vsColumbia | W62-54 | 12-10 | .545 | - | | Lavietes Pavilion · Cambridge, MA |
| 25 | Sat Feb 19 | vsCornell | W77-72 (OT) | 13-10 | .565 | - | | Lavietes Pavilion · Cambridge, MA |
| 26 | Fri Feb 25 | atPrinceton | L67-74 | 13-11 | .542 | - | ESPNEWS | Jadwin Gymnasium · Princeton, NJ |
| 27 | Sun Feb 27 | vsPrinceton | L73-74 | 13-12 | .520 | - | | Lavietes Pavilion · Cambridge, MA |
| 28 | Sat Mar 5 | vsDartmouth | L54-76 | 13-13 | .500 | - | | Lavietes Pavilion · Cambridge, MA |
