| 1 | Mon Nov 7 | at TBD | W68-63 | 1-0 | 1.000 | - | | Forbes Arena |
| 2 | Fri Nov 11 | vs Louisiana | L61-75 | 1-1 | .500 | - | | Lavietes Pavilion · Cambridge, MA |
| 3 | Sun Nov 13 | at Elon | W92-77 | 2-1 | .667 | - | ESPNU | Schar Center · Elon, NC |
| 4 | Wed Nov 16 | at Northeastern | W70-69 | 3-1 | .750 | - | | Matthews Arena · Boston, MA |
| 5 | Sun Nov 20 | vs Siena | W69-59 | 4-1 | .800 | - | | Lavietes Pavilion · Cambridge, MA |
| 6 | Fri Nov 25 | vs Loyola Chicago | W61-55 | 5-1 | .833 | - | | Lavietes Pavilion · Cambridge, MA |
| 7 | Sun Nov 27 | at Fordham | L60-68 | 5-2 | .714 | - | | Rose Hill Gymnasium · Bronx, NY |
| 8 | Wed Nov 30 | at Holy Cross | W72-38 | 6-2 | .750 | - | | Hart Center · Worcester, MA |
| 9 | Fri Dec 2 | vs UMass | L68-71 | 6-3 | .667 | - | | Lavietes Pavilion · Cambridge, MA |
| 10 | Sun Dec 4 | vsTBD | W76-59 | 7-3 | .700 | - | | Lavietes Pavilion · Cambridge, MA |
| 11 | Sun Dec 18 | vs Howard | L54-66 | 7-4 | .636 | - | | Lavietes Pavilion · Cambridge, MA |
| 12 | Tue Dec 20 | at UC Irvine | W62-57 | 8-4 | .667 | - | | Bren Events Center · Irvine, CA |
| 13 | Thu Dec 22 | at #4Kansas | L54-68 | 8-5 | .615 | - | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 14 | Wed Dec 28 | at Maine | W74-73 (OT) | 9-5 | .643 | - | | Cross Insurance Center · Bangor, ME |
| 15 | Sat Dec 31 | at Princeton | L66-69 | 9-6 | .600 | - | | Jadwin Gymnasium · Princeton, NJ |
| 16 | Fri Jan 6 | at Brown | W70-68 (OT) | 10-6 | .625 | - | | Pizzitola Sports Center · Providence, RI |
| 17 | Sat Jan 7 | at Yale | L54-58 | 10-7 | .588 | - | | John J. Lee Amphitheater · New Haven, CT |
| 18 | Sat Jan 14 | vs Columbia | W73-51 | 11-7 | .611 | - | | Lavietes Pavilion · Cambridge, MA |
| 19 | Mon Jan 16 | vs Dartmouth | L59-60 | 11-8 | .579 | - | | Lavietes Pavilion · Cambridge, MA |
| 20 | Sat Jan 21 | vs Cornell | W95-89 | 12-8 | .600 | - | | Lavietes Pavilion · Cambridge, MA |
| 21 | Sat Jan 28 | at Penn | L68-83 | 12-9 | .571 | - | | The Palestra · Philadelphia, PA |
| 22 | Fri Feb 3 | vsYale | L57-68 | 12-10 | .545 | - | ESPNU | Lavietes Pavilion · Cambridge, MA |
| 23 | Sat Feb 4 | vsBrown | L65-68 | 12-11 | .522 | - | | Lavietes Pavilion · Cambridge, MA |
| 24 | Sat Feb 11 | vsPenn | L72-80 | 12-12 | .500 | - | | Lavietes Pavilion · Cambridge, MA |
| 25 | Fri Feb 17 | atColumbia | W83-65 | 13-12 | .520 | - | | Francis S. Levien Gymnasium · New York, NY |
| 26 | Sat Feb 18 | atCornell | W73-56 | 14-12 | .538 | - | | Newman Arena · Ithaca, NY |
| 27 | Sat Feb 25 | vsPrinceton | L56-58 | 14-13 | .519 | - | | Lavietes Pavilion · Cambridge, MA |
| 28 | Sat Mar 4 | atDartmouth | L82-87 | 14-14 | .500 | - | | Edward Leede Arena · Hanover, NH |
