| 1 | Mon Nov 4 | vs Marist | W79-66 | 1-0 | 1.000 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 2 | Fri Nov 8 | atNavy | L80-85 | 1-1 | .500 | - | CBSSN | Alumni Hall (Navy) · Annapolis, MD |
| 3 | Sun Nov 10 | atAmerican | L55-67 | 1-2 | .333 | - | ESPN+ | Bender Arena · Washington, D.C. |
| 4 | Wed Nov 13 | atNortheastern | L56-78 | 1-3 | .250 | - | FloSports | Matthews Arena · Boston, MA |
| 5 | Sun Nov 17 | atColorado | L66-88 | 1-4 | .200 | - | ESPN+ | CU Events Center · Boulder, CO |
| 6 | Fri Nov 22 | vsColgate | W78-67 | 2-4 | .333 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 7 | Wed Nov 27 | vsUMass | L54-62 | 2-5 | .286 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 8 | Sat Nov 30 | atSt John's | L64-77 | 2-6 | .250 | - | Peacock | Carnesecca Arena · Queens, NY |
| 9 | Wed Dec 4 | atHoly Cross | L67-68 | 2-7 | .222 | - | ESPN+ | Hart Center · Worcester, MA |
| 10 | Sun Dec 8 | atNew Hampshire | W72-62 | 3-7 | .300 | - | ESPN+ | Lundholm Gymnasium · Durham, NH |
| 11 | Sat Dec 21 | vsFurman | L63-77 | 3-8 | .273 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 12 | Sun Dec 29 | atIona | W67-61 | 4-8 | .333 | - | ESPN+ | Hynes Athletics Center · New Rochelle, NY |
| 13 | Sun Jan 5 | vsTBD | W71-65 | 5-8 | .385 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 14 | Sat Jan 11 | vsPrinceton | L64-68 | 5-9 | .357 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 15 | Sat Jan 18 | atBrown | W80-67 | 6-9 | .400 | - | ESPN+ | Pizzitola Sports Center · Providence, RI |
| 16 | Mon Jan 20 | vsPenn | L67-82 | 6-10 | .375 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 17 | Sat Jan 25 | atYale | L55-84 | 6-11 | .353 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 18 | Fri Jan 31 | atColumbia | W90-82 | 7-11 | .389 | - | ESPN+ | Francis S. Levien Gymnasium · New York, NY |
| 19 | Sat Feb 1 | atCornell | L60-75 | 7-12 | .368 | - | ESPN+ | Newman Arena · Ithaca, NY |
| 20 | Sat Feb 8 | atDartmouth | L56-76 | 7-13 | .350 | - | ESPN+ | Edward Leede Arena · Hanover, NH |
| 21 | Fri Feb 14 | vsCornell | W75-73 | 8-13 | .381 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 22 | Sat Feb 15 | vsColumbia | W87-75 | 9-13 | .409 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 23 | Fri Feb 21 | atPrinceton | L71-76 | 9-14 | .391 | - | ESPN+ | Jadwin Gymnasium · Princeton, NJ |
| 24 | Sat Feb 22 | atPenn | W79-78 (OT) | 10-14 | .417 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 25 | Fri Feb 28 | vsBrown | L52-59 | 10-15 | .400 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 26 | Sat Mar 1 | vsYale | W74-69 | 11-15 | .423 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 27 | Sat Mar 8 | vsDartmouth | W66-58 | 12-15 | .444 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
