| 1 | Fri Nov 7 | vs TBD | 5:00 PM | 0-0 | .000 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 2 | Sun Nov 9 | vsNew Hampshire | 12:00 PM | 8-24 | .250 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 3 | Tue Nov 11 | vsNortheastern | 7:00 PM | 17-15 | .531 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 4 | Sat Nov 15 | atArmy | 2:00 PM | 17-16 | .515 | - | ESPN+ | Christl Arena · West Point, NY |
| 5 | Sun Nov 16 | atMarist | 5:00 PM | 20-10 | .667 | - | ESPN+ | McCann Arena · Poughkeepsie, NY |
| 6 | Wed Nov 19 | atPenn State | 6:30 PM | 16-15 | .516 | - | B1G+ | Bryce Jordan Center · University Park, PA |
| 7 | Sat Nov 22 | atBoston Univ | 1:30 PM | 16-16 | .500 | - | | Case Gym · Boston, MA |
| 8 | Wed Nov 26 | atBoston College | TBD | 12-19 | .387 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 9 | Sat Nov 29 | vsBryant | 2:00 PM | 23-12 | .657 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 10 | Wed Dec 3 | atUMass | 7:00 PM | 12-20 | .375 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 11 | Sat Dec 6 | atFurman | TBD | 25-10 | .714 | - | | Timmons Arena · Greenville, SC |
| 12 | Sat Dec 20 | vsHoly Cross | 2:00 PM | 13-19 | .406 | - | | Lavietes Pavilion · Cambridge, MA |
| 13 | Tue Dec 23 | at#5St John's | TBD | 31-5 | .861 | - | | Carnesecca Arena · Queens, NY |
| 14 | Sun Dec 28 | atColgate | 2:00 PM | 14-19 | .424 | - | | Cotterell Court · Hamilton, NY |
| 15 | Mon Jan 5 | vsDartmouth | TBD | 14-14 | .500 | - | | Lavietes Pavilion · Cambridge, MA |
| 16 | Sat Jan 10 | atColumbia | 2:00 PM | 12-15 | .444 | - | | Francis S. Levien Gymnasium · New York, NY |
| 17 | Sat Jan 17 | vsPrinceton | TBD | 19-11 | .633 | - | | Lavietes Pavilion · Cambridge, MA |
| 18 | Mon Jan 19 | vsPenn | TBD | 8-19 | .296 | - | | Lavietes Pavilion · Cambridge, MA |
| 19 | Sat Jan 24 | vsCornell | 2:00 PM | 18-11 | .621 | - | | Lavietes Pavilion · Cambridge, MA |
| 20 | Fri Jan 30 | atBrown | 7:00 PM | 14-13 | .519 | - | | Pizzitola Sports Center · Providence, RI |
| 21 | Sat Jan 31 | atYale | 7:00 PM | 22-8 | .733 | - | | John J. Lee Amphitheater · New Haven, CT |
| 22 | Sat Feb 7 | atDartmouth | TBD | 14-14 | .500 | - | | Edward Leede Arena · Hanover, NH |
| 23 | Fri Feb 13 | vsBrown | 7:00 PM | 14-13 | .519 | - | | Lavietes Pavilion · Cambridge, MA |
| 24 | Sat Feb 14 | vsYale | 7:00 PM | 22-8 | .733 | - | | Lavietes Pavilion · Cambridge, MA |
| 25 | Sat Feb 21 | atCornell | 2:00 PM | 18-11 | .621 | - | | Newman Arena · Ithaca, NY |
| 26 | Fri Feb 27 | atPrinceton | 7:00 PM | 19-11 | .633 | - | | Jadwin Gymnasium · Princeton, NJ |
| 27 | Sat Feb 28 | atPenn | TBD | 8-19 | .296 | - | | The Palestra · Philadelphia, PA |
| 28 | Sat Mar 7 | vsColumbia | 2:00 PM | 12-15 | .444 | - | | Lavietes Pavilion · Cambridge, MA |
