| 1 | Tue Nov 5 | vs TBD | W84-27 | 1-0 | 1.000 | - | | Lavietes Pavilion · Cambridge, MA |
| 2 | Fri Nov 8 | atNortheastern | L79-84 | 1-1 | .500 | - | | Matthews Arena · Boston, MA |
| 3 | Sun Nov 10 | vsMaine | W67-46 | 2-1 | .667 | - | | Lavietes Pavilion · Cambridge, MA |
| 4 | Thu Nov 14 | vsSiena | W59-56 | 3-1 | .750 | - | | Lavietes Pavilion · Cambridge, MA |
| 5 | Sat Nov 16 | atBuffalo | L76-88 | 3-2 | .600 | - | | Alumni Arena · Buffalo, NY |
| 6 | Fri Nov 22 | atHoly Cross | W82-74 | 4-2 | .667 | - | | Hart Center · Worcester, MA |
| 7 | Thu Nov 28 | vsTexas A&M | W62-51 | 5-2 | .714 | - | ESPN2 | Lavietes Pavilion · Cambridge, MA |
| 8 | Fri Nov 29 | vsMaryland | L73-80 | 5-3 | .625 | - | ESPN2 | Lavietes Pavilion · Cambridge, MA |
| 9 | Sun Dec 1 | atUSC | L62-77 | 5-4 | .556 | - | ESPN2 | Galen Center · Los Angeles, CA |
| 10 | Sat Dec 7 | vsUMass | W89-55 | 6-4 | .600 | - | | Lavietes Pavilion · Cambridge, MA |
| 11 | Sat Dec 21 | atG Washington | W88-75 | 7-4 | .636 | - | | Charles E. Smith Center · Washington, D.C. |
| 12 | Sun Dec 22 | atHoward | W60-55 | 8-4 | .667 | - | | Burr Gymnasium · Washington, D.C. |
| 13 | Sun Dec 29 | atCalifornia | W71-63 | 9-4 | .692 | - | PACN | Haas Pavilion · Berkeley, CA |
| 14 | Mon Dec 30 | atSan Francisco | W84-81 (OT) | 10-4 | .714 | - | | War Memorial at the Sobrato Center · San Francisco, CA |
| 15 | Sat Jan 4 | vsUC Irvine | W77-73 | 11-4 | .733 | - | | Lavietes Pavilion · Cambridge, MA |
| 16 | Sat Jan 18 | vsDartmouth | W67-62 | 12-4 | .750 | - | | Lavietes Pavilion · Cambridge, MA |
| 17 | Sat Jan 25 | atDartmouth | W70-66 | 13-4 | .765 | - | | Edward Leede Arena · Hanover, NH |
| 18 | Fri Jan 31 | atPenn | L72-75 (OT) | 13-5 | .722 | - | ESPNU | The Palestra · Philadelphia, PA |
| 19 | Sat Feb 1 | atPrinceton | L69-70 | 13-6 | .684 | - | | Jadwin Gymnasium · Princeton, NJ |
| 20 | Fri Feb 7 | atYale | W78-77 | 14-6 | .700 | - | ESPNU | John J. Lee Amphitheater · New Haven, CT |
| 21 | Sat Feb 8 | atBrown | L71-72 | 14-7 | .667 | - | | Pizzitola Sports Center · Providence, RI |
| 22 | Fri Feb 14 | vsCornell | W85-63 | 15-7 | .682 | - | | Lavietes Pavilion · Cambridge, MA |
| 23 | Sat Feb 15 | vsColumbia | W77-73 (2OT) | 16-7 | .696 | - | | Lavietes Pavilion · Cambridge, MA |
| 24 | Fri Feb 21 | vsPrinceton | W61-60 | 17-7 | .708 | - | | Lavietes Pavilion · Cambridge, MA |
| 25 | Sat Feb 22 | vsPenn | W69-65 | 18-7 | .720 | - | | Lavietes Pavilion · Cambridge, MA |
| 26 | Fri Feb 28 | atColumbia | W77-69 | 19-7 | .731 | - | ESPNEWS | Francis S. Levien Gymnasium · New York, NY |
| 27 | Sat Feb 29 | atCornell | W67-58 | 20-7 | .741 | - | | Newman Arena · Ithaca, NY |
| 28 | Fri Mar 6 | vsBrown | L55-64 | 20-8 | .714 | - | | Lavietes Pavilion · Cambridge, MA |
| 29 | Sat Mar 7 | vsYale | W83-69 | 21-8 | .724 | - | | Lavietes Pavilion · Cambridge, MA |
