| 1 | Mon Nov 4 | vs TBD | W82-52 | 1-0 | 1.000 | - | ESPN+ | Bren Events Center · Irvine, CA |
| 2 | Fri Nov 8 | at LMU | W66-51 | 2-0 | 1.000 | - | ESPN+ | Gersten Pavilion · Los Angeles, CA |
| 3 | Sun Nov 10 | at Northern Iowa | W80-60 | 3-0 | 1.000 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 4 | Sat Nov 16 | vs Pepperdine | W80-62 | 4-0 | 1.000 | - | ESPN+ | Bren Events Center · Irvine, CA |
| 5 | Fri Nov 22 | at Weber St | W93-87 | 5-0 | 1.000 | - | ESPN+ | Dee Events Center · Ogden, UT |
| 6 | Thu Nov 28 | vs Kennesaw St | W76-59 | 6-0 | 1.000 | - | ESPN+ | Bren Events Center · Irvine, CA |
| 7 | Fri Nov 29 | at Kent State | W51-39 | 7-0 | 1.000 | - | ESPN+ | M.A.C. Center · Kent, OH |
| 8 | Sat Nov 30 | at Towson | W67-60 | 8-0 | 1.000 | - | ESPN+ | SECU Arena · Towson, MD |
| 9 | Thu Dec 5 | vs Bakersfield | W82-66 | 9-0 | 1.000 | - | ESPN+ | Bren Events Center · Irvine, CA |
| 10 | Sat Dec 14 | at Oregon St | L55-67 | 9-1 | .900 | - | ESPN+ | Gill Coliseum · Corvallis, OR |
| 11 | Thu Dec 19 | at Belmont | W92-84 | 10-1 | .909 | - | ESPN+ | Curb Event Center Arena · Nashville, TN |
| 12 | Sat Dec 21 | at Duquesne | L54-70 | 10-2 | .833 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 13 | Mon Dec 30 | at CA Baptist | W71-63 | 11-2 | .846 | - | ESPN+ | CBU Events Center · Riverside, CA |
| 14 | Thu Jan 2 | at Cal Poly | W98-89 (OT) | 12-2 | .857 | - | ESPN+ | Robert A. Mott Athletics Center · San Luis Obispo, CA |
| 15 | Sat Jan 4 | vs UC Riverside | W81-57 | 13-2 | .867 | - | ESPN+ | Bren Events Center · Irvine, CA |
| 16 | Thu Jan 9 | at CSU Northridge | W77-67 | 14-2 | .875 | - | ESPN+ | Premier America Credit Union Arena · Northridge, CA |
| 17 | Sat Jan 11 | at UC San Diego | W60-52 | 15-2 | .882 | - | ESPNU | University Credit Union Center · Davis, CA |
| 18 | Thu Jan 16 | vs Fullerton | W82-62 | 16-2 | .889 | - | ESPN+ | Bren Events Center · Irvine, CA |
| 19 | Sat Jan 18 | vsCal Poly | W101-71 | 17-2 | .895 | - | ESPN+ | Bren Events Center · Irvine, CA |
| 20 | Thu Jan 23 | atUC Riverside | L80-84 (OT) | 17-3 | .850 | - | ESPN+ | SRC Arena · Riverside, CA |
| 21 | Sat Jan 25 | vs Hawai'i | W71-55 | 18-3 | .857 | - | ESPN+ | Bren Events Center · Irvine, CA |
| 22 | Thu Jan 30 | at Long Beach St | W80-75 (OT) | 19-3 | .864 | - | ESPN+ | Walter Pyramid · Long Beach, CA |
| 23 | Sat Feb 1 | vs UC Davis | W73-66 | 20-3 | .870 | - | ESPN+ | Bren Events Center · Irvine, CA |
| 24 | Sat Feb 8 | vsUC San Diego | L67-85 | 20-4 | .833 | - | ESPNU | Bren Events Center · Irvine, CA |
| 25 | Thu Feb 13 | vs UCSB | W62-60 | 21-4 | .840 | - | ESPNU | Bren Events Center · Irvine, CA |
| 26 | Sat Feb 15 | atHawai'i | W66-49 | 22-4 | .846 | - | ESPN+ | Stan Sheriff Center · Honolulu, HI |
| 27 | Thu Feb 20 | vsCSU Northridge | L72-84 | 22-5 | .815 | - | ESPN+ | Bren Events Center · Irvine, CA |
