| 1 | Tue Nov 7 | at San Jose St | L64-72 | 0-1 | .000 | - | | Provident Credit Union Event Center · San Jose, CA |
| 2 | Sat Nov 11 | vs New Mexico St | W91-74 | 1-1 | .500 | - | | Bren Events Center · Irvine, CA |
| 3 | Tue Nov 14 | at #16USC | W70-60 | 2-1 | .667 | - | PACN | Galen Center · Los Angeles, CA |
| 4 | Fri Nov 17 | vs TBD | W111-51 | 3-1 | .750 | - | | Bren Events Center · Irvine, CA |
| 5 | Tue Nov 21 | at Pepperdine | W76-60 | 4-1 | .800 | - | | Firestone Fieldhouse · Malibu, CA |
| 6 | Wed Nov 22 | vs Toledo | W77-71 | 5-1 | .833 | - | | Bren Events Center · Irvine, CA |
| 7 | Fri Nov 24 | at Rice | W83-68 | 6-1 | .857 | - | | Tudor Fieldhouse · Houston, TX |
| 8 | Wed Nov 29 | at Duquesne | L62-66 | 6-2 | .750 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 9 | Sat Dec 2 | at Utah State | L69-79 | 6-3 | .667 | - | | Dee Glen Smith Spectrum · Logan, UT |
| 10 | Sat Dec 9 | at #25SDSU | L62-63 | 6-4 | .600 | - | FS1 | Viejas Arena · San Diego, CA |
| 11 | Sat Dec 16 | vs South Dakota | W121-78 | 7-4 | .636 | - | | Bren Events Center · Irvine, CA |
| 12 | Wed Dec 20 | at New Mexico | L65-78 | 7-5 | .583 | - | | The Pit · Albuquerque, NM |
| 13 | Thu Dec 28 | vs UC Riverside | W73-66 | 8-5 | .615 | - | | Bren Events Center · Irvine, CA |
| 14 | Sat Dec 30 | at Bakersfield | W75-56 | 9-5 | .643 | - | | Icardo Center · Bakersfield, CA |
| 15 | Thu Jan 4 | vs Fullerton | W75-67 | 10-5 | .667 | - | | Bren Events Center · Irvine, CA |
| 16 | Sat Jan 6 | vs UC Davis | W74-71 (OT) | 11-5 | .688 | - | | Bren Events Center · Irvine, CA |
| 17 | Thu Jan 11 | at Hawai'i | W60-50 | 12-5 | .706 | - | | Stan Sheriff Center · Honolulu, HI |
| 18 | Thu Jan 18 | vs UC San Diego | W76-65 | 13-5 | .722 | - | | Bren Events Center · Irvine, CA |
| 19 | Sat Jan 20 | atUC Davis | L52-54 | 13-6 | .684 | - | | University Credit Union Center · Davis, CA |
| 20 | Thu Jan 25 | at Long Beach St | W72-61 | 14-6 | .700 | - | | Walter Pyramid · Long Beach, CA |
| 21 | Sat Jan 27 | vs CSU Northridge | W77-72 | 15-6 | .714 | - | | Bren Events Center · Irvine, CA |
| 22 | Thu Feb 1 | at Cal Poly | W73-59 | 16-6 | .727 | - | | Robert A. Mott Athletics Center · San Luis Obispo, CA |
| 23 | Sat Feb 3 | vsHawai'i | W93-68 | 17-6 | .739 | - | | Bren Events Center · Irvine, CA |
| 24 | Thu Feb 8 | at UCSB | W76-61 | 18-6 | .750 | - | | The Thunderdome · Santa Barbara, CA |
| 25 | Sat Feb 10 | atUC Riverside | L78-88 | 18-7 | .720 | - | | SRC Arena · Riverside, CA |
| 26 | Sat Feb 17 | vsBakersfield | W77-71 | 19-7 | .731 | - | | Bren Events Center · Irvine, CA |
| 27 | Thu Feb 22 | vsUCSB | W81-69 | 20-7 | .741 | - | ESPNU | Bren Events Center · Irvine, CA |
| 28 | Sat Feb 24 | atUC San Diego | L88-92 (OT) | 20-8 | .714 | - | | University Credit Union Center · Davis, CA |
| 29 | Thu Feb 29 | atCSU Northridge | W89-64 | 21-8 | .724 | - | | Premier America Credit Union Arena · Northridge, CA |
| 30 | Sat Mar 2 | vsLong Beach St | W82-61 | 22-8 | .733 | - | ESPN2 | Bren Events Center · Irvine, CA |
| 31 | Thu Mar 7 | vsCal Poly | W82-68 | 23-8 | .742 | - | | Bren Events Center · Irvine, CA |
| 32 | Sat Mar 9 | atFullerton | W81-71 | 24-8 | .750 | - | | Titan Gym · Fullerton, CA |
| 33 | Fri Mar 15 | vsLong Beach St | L79-83 | 24-9 | .727 | - | | Bren Events Center · Irvine, CA |
| 34 | Tue Mar 19 | at Utah | L75-84 | 24-10 | .706 | - | ESPN2 | Jon M. Huntsman Center · Salt Lake City, UT |
