| 1 | Mon Nov 7 | vs TBD | W96-50 | 1-0 | 1.000 | - | | Bren Events Center · Irvine, CA |
| 2 | Fri Nov 11 | at #21Oregon | W69-56 | 2-0 | 1.000 | - | | Matthew Knight Arena · Eugene, OR |
| 3 | Tue Nov 15 | vs LMU | W79-64 | 3-0 | 1.000 | - | | Bren Events Center · Irvine, CA |
| 4 | Sat Nov 19 | at Pepperdine | L55-64 | 3-1 | .750 | - | | Firestone Fieldhouse · Malibu, CA |
| 5 | Mon Nov 21 | vsTBD | W116-54 | 4-1 | .800 | - | | Bren Events Center · Irvine, CA |
| 6 | Fri Nov 25 | vs Nicholls | W83-56 | 5-1 | .833 | - | | Bren Events Center · Irvine, CA |
| 7 | Sat Nov 26 | vs New Mexico St | W85-68 | 6-1 | .857 | - | | Bren Events Center · Irvine, CA |
| 8 | Tue Nov 29 | at #24SDSU | L69-72 | 6-2 | .750 | - | | Viejas Arena · San Diego, CA |
| 9 | Sat Dec 3 | vs Fresno St | L66-80 | 6-3 | .667 | - | | Bren Events Center · Irvine, CA |
| 10 | Sat Dec 10 | at South Dakota | W83-71 | 7-3 | .700 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 11 | Thu Dec 15 | at Santa Clara | L74-86 | 7-4 | .636 | - | | Leavey Center · Santa Clara, CA |
| 12 | Tue Dec 20 | vs Harvard | L57-62 | 7-5 | .583 | - | | Bren Events Center · Irvine, CA |
| 13 | Sat Dec 31 | at Bakersfield | W79-75 | 8-5 | .615 | - | | Icardo Center · Bakersfield, CA |
| 14 | Thu Jan 5 | at UC Davis | W88-83 | 9-5 | .643 | - | | University Credit Union Center · Davis, CA |
| 15 | Sat Jan 7 | vs Long Beach St | W87-70 | 10-5 | .667 | - | | Bren Events Center · Irvine, CA |
| 16 | Wed Jan 11 | vs Fullerton | W70-65 | 11-5 | .688 | - | | Bren Events Center · Irvine, CA |
| 17 | Sat Jan 14 | at CSU Northridge | W71-57 | 12-5 | .706 | - | | Premier America Credit Union Arena · Northridge, CA |
| 18 | Mon Jan 16 | vs UCSB | L65-73 | 12-6 | .667 | - | | Bren Events Center · Irvine, CA |
| 19 | Thu Jan 19 | vs Hawai'i | W76-68 | 13-6 | .684 | - | | Bren Events Center · Irvine, CA |
| 20 | Thu Jan 26 | atFullerton | L61-62 | 13-7 | .650 | - | | Titan Gym · Fullerton, CA |
| 21 | Sat Jan 28 | vsCSU Northridge | W81-56 | 14-7 | .667 | - | | Bren Events Center · Irvine, CA |
| 22 | Thu Feb 2 | at UC San Diego | W76-60 | 15-7 | .682 | - | | University Credit Union Center · Davis, CA |
| 23 | Sat Feb 4 | atLong Beach St | L88-93 (OT) | 15-8 | .652 | - | | Walter Pyramid · Long Beach, CA |
| 24 | Thu Feb 9 | vs Cal Poly | W55-54 | 16-8 | .667 | - | | Bren Events Center · Irvine, CA |
| 25 | Sat Feb 11 | vs UC Riverside | W83-64 | 17-8 | .680 | - | ESPNU | Bren Events Center · Irvine, CA |
| 26 | Wed Feb 15 | atUCSB | W70-59 | 18-8 | .692 | - | | The Thunderdome · Santa Barbara, CA |
| 27 | Sat Feb 18 | vsUC Davis | W78-76 | 19-8 | .704 | - | | Bren Events Center · Irvine, CA |
| 28 | Mon Feb 20 | atCal Poly | W59-56 | 20-8 | .714 | - | | Robert A. Mott Athletics Center · San Luis Obispo, CA |
| 29 | Thu Feb 23 | vsUC San Diego | L91-99 | 20-9 | .690 | - | | Bren Events Center · Irvine, CA |
| 30 | Sat Feb 25 | atHawai'i | L67-72 | 20-10 | .667 | - | ESPNEWS | Stan Sheriff Center · Honolulu, HI |
| 31 | Thu Mar 2 | atUC Riverside | W75-65 | 21-10 | .677 | - | | SRC Arena · Riverside, CA |
| 32 | Sat Mar 4 | vsBakersfield | W52-44 | 22-10 | .688 | - | | Bren Events Center · Irvine, CA |
| 33 | Thu Mar 9 | vsBakersfield | W75-51 | 23-10 | .697 | - | | Bren Events Center · Irvine, CA |
| 34 | Fri Mar 10 | vsFullerton | L80-83 | 23-11 | .676 | - | | Bren Events Center · Irvine, CA |
| 35 | Wed Mar 15 | atOregon | L58-84 | 23-12 | .657 | - | ESPN2 | Matthew Knight Arena · Eugene, OR |
