| 1 | Mon Nov 4 | vs Saint Louis | W85-78 | 1-0 | 1.000 | - | | Leavey Center · Santa Clara, CA |
| 2 | Fri Nov 8 | at Arizona St | L74-81 | 1-1 | .500 | - | FloSports | Desert Financial Arena · Tempe, AZ |
| 3 | Wed Nov 13 | vs N Dakota St | L80-88 (OT) | 1-2 | .333 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 4 | Sat Nov 16 | at Nevada | L59-85 | 1-3 | .250 | - | | Lawlor Events Center · Reno, NV |
| 5 | Tue Nov 19 | vs UC Riverside | W96-54 | 2-3 | .400 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 6 | Sat Nov 23 | vs Stanford | L69-71 | 2-4 | .333 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 7 | Thu Nov 28 | at TCU | W69-52 | 3-4 | .429 | - | truTV | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 8 | Fri Nov 29 | at Washington | L69-76 | 3-5 | .375 | - | | Alaska Airlines Arena · Seattle, WA |
| 9 | Tue Dec 3 | at McNeese | W74-67 | 4-5 | .444 | - | ESPN+ | Legacy Center · Lake Charles, LA |
| 10 | Sat Dec 7 | vs Fresno St | W81-66 | 5-5 | .500 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 11 | Sat Dec 14 | vs Bradley | W84-74 | 6-5 | .545 | - | | Leavey Center · Santa Clara, CA |
| 12 | Wed Dec 18 | vs Kennesaw St | W94-74 | 7-5 | .583 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 13 | Sat Dec 21 | vs South Dakota | W98-81 | 8-5 | .615 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 14 | Sat Dec 28 | vs Pepperdine | W91-80 | 9-5 | .643 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 15 | Mon Dec 30 | at San Francisco | L94-97 (OT) | 9-6 | .600 | - | ESPN+ | War Memorial at the Sobrato Center · San Francisco, CA |
| 16 | Thu Jan 2 | at San Diego | W81-80 | 10-6 | .625 | - | ESPN+ | Jenny Craig Pavilion · San Diego, CA |
| 17 | Thu Jan 9 | vs Oregon St | W82-81 (OT) | 11-6 | .647 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 18 | Sat Jan 11 | vsSan Francisco | W77-54 | 12-6 | .667 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 19 | Thu Jan 16 | at LMU | L54-57 | 12-7 | .632 | - | ESPN+ | Gersten Pavilion · Los Angeles, CA |
| 20 | Sat Jan 18 | at #16Gonzaga | W103-99 | 13-7 | .650 | - | ESPN+ | McCarthey Athletic Center · Spokane, WA |
| 21 | Thu Jan 23 | vs Washington St | W93-65 | 14-7 | .667 | - | CBS | Leavey Center · Santa Clara, CA |
| 22 | Sat Jan 25 | atOregon St | L69-83 | 14-8 | .636 | - | ESPN+ | Gill Coliseum · Corvallis, OR |
| 23 | Wed Jan 29 | vs Saint Mary's | L54-67 | 14-9 | .609 | - | ESPNU | Leavey Center · Santa Clara, CA |
| 24 | Sat Feb 1 | vs Pacific | W83-49 | 15-9 | .625 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 25 | Thu Feb 6 | at Portland | W97-50 | 16-9 | .640 | - | ESPN+ | Chiles Center · Portland, OR |
| 26 | Sat Feb 8 | vsSan Diego | W93-70 | 17-9 | .654 | - | ESPN+ | Leavey Center · Santa Clara, CA |
| 27 | Tue Feb 11 | atSaint Mary's | L64-73 | 17-10 | .630 | - | ESPN2 | University Credit Union Pavilion · Moraga, CA |
| 28 | Thu Feb 20 | vsLMU | W76-61 | 18-10 | .643 | - | ESPN2 | Leavey Center · Santa Clara, CA |
| 29 | Sat Feb 22 | atWashington St | W109-79 | 19-10 | .655 | - | CBS | Friel Court at Beasley Coliseum · Pullman, WA |
| 30 | Tue Feb 25 | vsGonzaga | L76-95 | 19-11 | .633 | - | CBS | Leavey Center · Santa Clara, CA |
| 31 | Sat Mar 1 | atPacific | W97-66 | 20-11 | .645 | - | ESPN+ | Alex G. Spanos Center · Stockton, CA |
| 32 | Sun Mar 9 | vsPepperdine | L76-78 | 20-12 | .625 | - | ESPN2 | Leavey Center · Santa Clara, CA |
| 33 | Tue Mar 18 | vsUC Riverside | W101-62 | 21-12 | .636 | - | ESPNU | Leavey Center · Santa Clara, CA |
| 34 | Sun Mar 23 | vs UAB | L84-88 | 21-13 | .618 | - | ESPNU | Leavey Center · Santa Clara, CA |
