| 1 | Wed Nov 8 | vs Utah Tech | W77-69 | 1-0 | 1.000 | - | | Leavey Center · Santa Clara, CA |
| 2 | Sat Nov 11 | vsSt Francis PA | W82-59 | 2-0 | 1.000 | - | | Leavey Center · Santa Clara, CA |
| 3 | Tue Nov 14 | atStanford | W89-77 | 3-0 | 1.000 | - | | Maples Pavilion · Stanford, CA |
| 4 | Sat Nov 18 | vsSE Louisiana | W65-63 | 4-0 | 1.000 | - | | Leavey Center · Santa Clara, CA |
| 5 | Mon Nov 20 | vsMiss Valley St | W81-39 | 5-0 | 1.000 | - | | Leavey Center · Santa Clara, CA |
| 6 | Fri Nov 24 | atOregon | W88-82 | 6-0 | 1.000 | - | CBS | Matthew Knight Arena · Eugene, OR |
| 7 | Sat Nov 25 | vsOhio State | L56-86 | 6-1 | .857 | - | | Leavey Center · Santa Clara, CA |
| 8 | Wed Nov 29 | vsTBD | W106-69 | 7-1 | .875 | - | | Leavey Center · Santa Clara, CA |
| 9 | Sat Dec 2 | atCalifornia | L69-84 | 7-2 | .778 | - | PACN | Haas Pavilion · Berkeley, CA |
| 10 | Sat Dec 9 | atNew Mexico | L76-93 | 7-3 | .700 | - | | The Pit · Albuquerque, NM |
| 11 | Wed Dec 13 | vsUtah State | L82-84 | 7-4 | .636 | - | | Leavey Center · Santa Clara, CA |
| 12 | Sat Dec 16 | vsWashington St | W69-61 | 8-4 | .667 | - | PACN | Leavey Center · Santa Clara, CA |
| 13 | Wed Dec 20 | atSan Jose St | L78-81 | 8-5 | .615 | - | | Provident Credit Union Event Center · San Jose, CA |
| 14 | Sat Dec 23 | vsDuquesne | W81-73 | 9-5 | .643 | - | | Leavey Center · Santa Clara, CA |
| 15 | Sat Dec 30 | vsYale | L58-66 | 9-6 | .600 | - | | Leavey Center · Santa Clara, CA |
| 16 | Thu Jan 4 | atLMU | W68-57 | 10-6 | .625 | - | | Gersten Pavilion · Los Angeles, CA |
| 17 | Sat Jan 6 | atPepperdine | W78-72 | 11-6 | .647 | - | | Firestone Fieldhouse · Malibu, CA |
| 18 | Thu Jan 11 | vs#23Gonzaga | W77-76 | 12-6 | .667 | - | ESPN | Leavey Center · Santa Clara, CA |
| 19 | Sat Jan 13 | vsSaint Mary's | L49-73 | 12-7 | .632 | - | | Leavey Center · Santa Clara, CA |
| 20 | Thu Jan 18 | atPacific | W88-69 | 13-7 | .650 | - | | Alex G. Spanos Center · Stockton, CA |
| 21 | Sat Jan 20 | vsPortland | W101-86 | 14-7 | .667 | - | | Leavey Center · Santa Clara, CA |
| 22 | Thu Jan 25 | vsPepperdine | W94-71 | 15-7 | .682 | - | | Leavey Center · Santa Clara, CA |
| 23 | Wed Jan 31 | atSaint Mary's | L77-82 | 15-8 | .652 | - | ESPNU | University Credit Union Pavilion · Moraga, CA |
| 24 | Sat Feb 3 | vsSan Diego | L59-70 | 15-9 | .625 | - | | Leavey Center · Santa Clara, CA |
| 25 | Sat Feb 10 | atSan Francisco | L70-71 | 15-10 | .600 | - | | War Memorial at the Sobrato Center · San Francisco, CA |
| 26 | Thu Feb 15 | vsPacific | W79-53 | 16-10 | .615 | - | | Leavey Center · Santa Clara, CA |
| 27 | Sat Feb 17 | atSan Diego | W82-69 | 17-10 | .630 | - | | Jenny Craig Pavilion · San Diego, CA |
| 28 | Thu Feb 22 | vsLMU | W65-55 | 18-10 | .643 | - | CBS | Leavey Center · Santa Clara, CA |
| 29 | Sat Feb 24 | atGonzaga | L81-94 | 18-11 | .621 | - | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 30 | Thu Feb 29 | atPortland | L75-80 (OT) | 18-12 | .600 | - | | Chiles Center · Portland, OR |
| 31 | Sat Mar 2 | vsSan Francisco | W69-62 | 19-12 | .613 | - | | Leavey Center · Santa Clara, CA |
| 32 | Sat Mar 9 | vsSan Diego | W104-79 | 20-12 | .625 | - | ESPN2 | Leavey Center · Santa Clara, CA |
| 33 | Mon Mar 11 | at#21Saint Mary's | L65-79 | 20-13 | .606 | - | ESPN | University Credit Union Pavilion · Moraga, CA |
