| 1 | Tue Nov 5 | vs TBD | W97-52 | 1-0 | 1.000 | - | | Leavey Center · Santa Clara, CA |
| 2 | Fri Nov 8 | vsCal Poly | W77-63 | 2-0 | 1.000 | - | | Leavey Center · Santa Clara, CA |
| 3 | Tue Nov 12 | vsWashington St | W70-62 | 3-0 | 1.000 | - | | Leavey Center · Santa Clara, CA |
| 4 | Sat Nov 16 | atStanford | L64-82 | 3-1 | .750 | - | | Maples Pavilion · Stanford, CA |
| 5 | Tue Nov 19 | vsTBD | W101-54 | 4-1 | .800 | - | | Leavey Center · Santa Clara, CA |
| 6 | Fri Nov 22 | vsIdaho St | W78-65 | 5-1 | .833 | - | | Leavey Center · Santa Clara, CA |
| 7 | Wed Nov 27 | vsDenver | W81-64 | 6-1 | .857 | - | | Leavey Center · Santa Clara, CA |
| 8 | Fri Nov 29 | vsSE Missouri St | W87-75 | 7-1 | .875 | - | | Leavey Center · Santa Clara, CA |
| 9 | Sat Nov 30 | vsFullerton | W70-55 | 8-1 | .889 | - | | Leavey Center · Santa Clara, CA |
| 10 | Wed Dec 4 | atNevada | L67-98 | 8-2 | .800 | - | | Barclays Center · Brooklyn, NY |
| 11 | Sat Dec 7 | vsCalifornia | W71-52 | 9-2 | .818 | - | | Leavey Center · Santa Clara, CA |
| 12 | Sat Dec 14 | vsSacramento St | W60-58 | 10-2 | .833 | - | | Leavey Center · Santa Clara, CA |
| 13 | Wed Dec 18 | vsSan Jose St | W89-84 | 11-2 | .846 | - | | Leavey Center · Santa Clara, CA |
| 14 | Fri Dec 20 | vsMiss Valley St | W100-71 | 12-2 | .857 | - | | Leavey Center · Santa Clara, CA |
| 15 | Sun Dec 29 | vsAlcorn St | W92-57 | 13-2 | .867 | - | | Leavey Center · Santa Clara, CA |
| 16 | Sat Jan 4 | vsSan Diego | W80-63 | 14-2 | .875 | - | | Leavey Center · Santa Clara, CA |
| 17 | Thu Jan 9 | atSan Francisco | L61-80 | 14-3 | .824 | - | | War Memorial at the Sobrato Center · San Francisco, CA |
| 18 | Sat Jan 11 | atSaint Mary's | W67-66 | 15-3 | .833 | - | ESPNU | University Credit Union Pavilion · Moraga, CA |
| 19 | Thu Jan 16 | at1Gonzaga | L54-104 | 15-4 | .789 | - | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 20 | Sat Jan 18 | vsPacific | W84-80 | 16-4 | .800 | - | | Leavey Center · Santa Clara, CA |
| 21 | Thu Jan 23 | vsPepperdine | L86-90 (OT) | 16-5 | .762 | - | | Leavey Center · Santa Clara, CA |
| 22 | Sat Jan 25 | atSan Diego | W65-52 | 17-5 | .773 | - | | Jenny Craig Pavilion · San Diego, CA |
| 23 | Thu Jan 30 | vs2Gonzaga | L72-87 | 17-6 | .739 | - | CBSSN | Leavey Center · Santa Clara, CA |
| 24 | Sat Feb 1 | atPortland | W85-61 | 18-6 | .750 | - | | Chiles Center · Portland, OR |
| 25 | Thu Feb 6 | atPepperdine | L77-91 | 18-7 | .720 | - | | Firestone Fieldhouse · Malibu, CA |
| 26 | Thu Feb 13 | vsSan Francisco | L61-70 | 18-8 | .692 | - | | Leavey Center · Santa Clara, CA |
| 27 | Sat Feb 15 | vsLMU | L59-65 | 18-9 | .667 | - | | Leavey Center · Santa Clara, CA |
| 28 | Thu Feb 20 | at23BYU | L75-85 | 18-10 | .643 | - | CBSSN | Marriott Center · Provo, UT |
| 29 | Sat Feb 22 | atPacific | L74-87 | 18-11 | .621 | - | | Alex G. Spanos Center · Stockton, CA |
| 30 | Thu Feb 27 | vsSaint Mary's | L72-78 | 18-12 | .600 | - | CBSSN | Leavey Center · Santa Clara, CA |
| 31 | Sat Feb 29 | vsPortland | W73-68 | 19-12 | .613 | - | | Leavey Center · Santa Clara, CA |
| 32 | Thu Mar 5 | vsPortland | W76-62 | 20-12 | .625 | - | | Orleans Arena · Las Vegas, NV |
| 33 | Fri Mar 6 | atPepperdine | L73-84 | 20-13 | .606 | - | | Orleans Arena · Las Vegas, NV |
