| 1 | Mon Nov 3 | at Saint Louis | L67-92 | 0-1 | .000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 2 | Fri Nov 7 | atMissouri | L84-89 | 0-2 | .000 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 3 | Wed Nov 12 | vsTBD | W87-41 | 1-2 | .333 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 4 | Sat Nov 15 | vsSt Thomas (MN) | L72-84 | 1-3 | .250 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 5 | Tue Nov 18 | atIowa | L70-99 | 1-4 | .200 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 6 | Tue Nov 25 | atCal Poly | W84-68 | 2-4 | .333 | - | | J. Lawrence Walkup Skydome · Flagstaff, AZ |
| 7 | Wed Nov 26 | atN Arizona | L72-79 | 2-5 | .286 | - | ESPN+ | J. Lawrence Walkup Skydome · Flagstaff, AZ |
| 8 | Sat Nov 29 | vsLipscomb | L77-88 | 2-6 | .250 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 9 | Tue Dec 2 | vsTBD | W88-57 | 3-6 | .333 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 10 | Sat Dec 6 | atChattanooga | W74-70 | 4-6 | .400 | - | ESPN+ | McKenzie Arena · Chattanooga, TN |
| 11 | Sun Dec 14 | vsTBD | W88-65 | 5-6 | .455 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 12 | Thu Dec 18 | atTennessee Tech | L74-85 | 5-7 | .417 | - | ESPN+ | Hooper Eblen Center · Cookeville, TN |
| 13 | Sat Dec 20 | atTennessee St | W91-82 | 6-7 | .462 | - | ESPN+ | Gentry Center · Nashville, TN |
| 14 | Thu Jan 1 | vsE Illinois | W68-59 | 7-7 | .500 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 15 | Sat Jan 3 | vsW Illinois | W73-50 | 8-7 | .533 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 16 | Thu Jan 8 | atSo Indiana | W84-76 | 9-7 | .563 | - | ESPN+ | Screaming Eagles Arena · Evansville, IN |
| 17 | Sat Jan 10 | atMorehead St | L69-71 | 9-8 | .529 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 18 | Thu Jan 15 | vsLindenwood | L76-88 | 9-9 | .500 | - | ESPNU | Show Me Center · Cape Girardeau, MO |
| 19 | Sat Jan 17 | vsSIUE | L55-68 | 9-10 | .474 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 20 | Tue Jan 20 | vsUT Martin | W66-50 | 10-10 | .500 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 21 | Thu Jan 22 | vsLittle Rock | W70-65 | 11-10 | .524 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 22 | Thu Jan 29 | atW Illinois | W78-74 | 12-10 | .545 | - | ESPN+ | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 23 | Sat Jan 31 | atE Illinois | W77-59 | 13-10 | .565 | - | ESPN+ | Lantz Arena · Charleston, IL |
| 24 | Thu Feb 5 | vsMorehead St | W82-70 | 14-10 | .583 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 25 | Sat Feb 7 | vsSo Indiana | W90-65 | 15-10 | .600 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 26 | Thu Feb 12 | atSIUE | L56-74 | 15-11 | .577 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 27 | Sat Feb 14 | atLindenwood | W73-61 | 16-11 | .593 | - | ESPN+ | placeholder · sf, ca |
| 28 | Tue Feb 17 | atUT Martin | W56-53 (OT) | 17-11 | .607 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 29 | Sat Feb 21 | atLittle Rock | W70-65 | 18-11 | .621 | - | ESPN+ | Jack Stephens Center · Little Rock, AR |
| 30 | Thu Feb 26 | vsTennessee St | L71-79 | 18-12 | .600 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 31 | Sat Feb 28 | vsTennessee Tech | W89-73 | 19-12 | .613 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
