| 1 | Tue Nov 9 | at Missouri St | W99-94 | 1-0 | 1.000 | - | | Great Southern Bank Arena · Springfield, MO |
| 2 | Sat Nov 13 | vs Youngstown St | L79-97 | 1-1 | .500 | - | | Show Me Center · Cape Girardeau, MO |
| 3 | Fri Nov 19 | vs Arkansas St | L60-72 | 1-2 | .333 | - | | Show Me Center · Cape Girardeau, MO |
| 4 | Mon Nov 22 | vs TBD | W71-63 | 2-2 | .500 | - | | Show Me Center · Cape Girardeau, MO |
| 5 | Fri Nov 26 | at Incarnate Word | W79-76 | 3-2 | .600 | - | | Alice P. McDermott Convocation Center · San Antonio, TX |
| 6 | Sat Nov 27 | at Portland | L68-74 | 3-3 | .500 | - | | Chiles Center · Portland, OR |
| 7 | Sun Nov 28 | at Montana St | L68-75 | 3-4 | .429 | - | | Worthington Arena · Bozeman, MT |
| 8 | Sat Dec 4 | vsTBD | W76-64 | 4-4 | .500 | - | | Show Me Center · Cape Girardeau, MO |
| 9 | Wed Dec 8 | vs Evansville | W75-73 | 5-4 | .556 | - | | Show Me Center · Cape Girardeau, MO |
| 10 | Sat Dec 11 | at Purdue FW | L65-78 | 5-5 | .500 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 11 | Wed Dec 15 | at S Illinois | L55-80 | 5-6 | .455 | - | | Banterra Center · Carbondale, IL |
| 12 | Sat Dec 18 | at Pepperdine | L77-83 | 5-7 | .417 | - | | Firestone Fieldhouse · Malibu, CA |
| 13 | Tue Dec 21 | at CA Baptist | L68-84 | 5-8 | .385 | - | | CBU Events Center · Riverside, CA |
| 14 | Thu Dec 30 | at Murray St | L81-106 | 5-9 | .357 | - | | CFSB Center · Murray, KY |
| 15 | Sat Jan 1 | vs Austin Peay | W98-79 | 6-9 | .400 | - | | Show Me Center · Cape Girardeau, MO |
| 16 | Thu Jan 6 | at Belmont | L62-102 | 6-10 | .375 | - | | Curb Event Center Arena · Nashville, TN |
| 17 | Sat Jan 8 | at Tennessee St | L84-95 | 6-11 | .353 | - | | Gentry Center · Nashville, TN |
| 18 | Sat Jan 15 | at SIUE | PPD | 14-18 | .438 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 19 | Thu Jan 20 | vsTennessee St | W85-63 | 7-11 | .389 | - | | Show Me Center · Cape Girardeau, MO |
| 20 | Sat Jan 22 | at E Illinois | W87-58 | 8-11 | .421 | - | | Lantz Arena · Charleston, IL |
| 21 | Thu Jan 27 | vs Morehead St | L73-74 (OT) | 8-12 | .400 | - | ESPNU | Show Me Center · Cape Girardeau, MO |
| 22 | Sat Jan 29 | vsSIUE | W85-77 | 9-12 | .429 | - | | Show Me Center · Cape Girardeau, MO |
| 23 | Thu Feb 3 | at UT Martin | L63-84 | 9-13 | .409 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 24 | Sat Feb 5 | vsE Illinois | W63-56 | 10-13 | .435 | - | | Show Me Center · Cape Girardeau, MO |
| 25 | Mon Feb 7 | atSIUE | W76-47 | 11-13 | .458 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 26 | Thu Feb 10 | atAustin Peay | L66-74 | 11-14 | .440 | - | | Winfield Dunn Center · Clarksville, TN |
| 27 | Sat Feb 12 | vsBelmont | L72-81 | 11-15 | .423 | - | | Show Me Center · Cape Girardeau, MO |
| 28 | Thu Feb 17 | at Tennessee Tech | L94-98 | 11-16 | .407 | - | | Hooper Eblen Center · Cookeville, TN |
| 29 | Sat Feb 19 | atMorehead St | W92-84 | 12-16 | .429 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 30 | Thu Feb 24 | vsUT Martin | W76-69 | 13-16 | .448 | - | | Show Me Center · Cape Girardeau, MO |
| 31 | Sat Feb 26 | vs#19Murray St | L68-70 | 13-17 | .433 | - | | Show Me Center · Cape Girardeau, MO |
| 32 | Thu Mar 3 | vsTennessee St | W79-55 | 14-17 | .452 | - | | Show Me Center · Cape Girardeau, MO |
| 33 | Fri Mar 4 | atMurray St | L74-88 | 14-18 | .438 | - | ESPNU | CFSB Center · Murray, KY |
