| 1 | Mon Nov 7 | at South Florida | W64-61 | 1-0 | 1.000 | - | | Yuengling Center · Tampa, FL |
| 2 | Sat Nov 12 | vs TBD | W83-46 | 2-0 | 1.000 | - | | Show Me Center · Cape Girardeau, MO |
| 3 | Wed Nov 16 | at Evansville | W67-61 | 3-0 | 1.000 | - | | Ford Center · Evansville, IN |
| 4 | Sat Nov 19 | at Bradley | L60-73 | 3-1 | .750 | - | | Carver Arena · Peoria, IL |
| 5 | Tue Nov 22 | vsTBD | W87-49 | 4-1 | .800 | - | | Show Me Center · Cape Girardeau, MO |
| 6 | Sat Nov 26 | vs Boston Univ | W63-52 | 5-1 | .833 | - | | Show Me Center · Cape Girardeau, MO |
| 7 | Sun Nov 27 | at UC Davis | L71-73 | 5-2 | .714 | - | | University Credit Union Center · Davis, CA |
| 8 | Mon Nov 28 | at Milwaukee | L68-84 | 5-3 | .625 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 9 | Sun Dec 4 | at Missouri | L89-96 | 5-4 | .556 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 10 | Wed Dec 7 | vs Purdue FW | L68-89 | 5-5 | .500 | - | | Show Me Center · Cape Girardeau, MO |
| 11 | Wed Dec 14 | at Arkansas St | L61-68 | 5-6 | .455 | - | | First National Bank Arena · Jonesboro, AR |
| 12 | Sat Dec 17 | at Iowa | L75-106 | 5-7 | .417 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 13 | Wed Dec 21 | vs S Illinois | L68-70 | 5-8 | .385 | - | | Show Me Center · Cape Girardeau, MO |
| 14 | Thu Dec 29 | at So Indiana | L81-86 | 5-9 | .357 | - | | Screaming Eagles Arena · Evansville, IN |
| 15 | Sat Dec 31 | vs SIUE | W82-73 | 6-9 | .400 | - | | Show Me Center · Cape Girardeau, MO |
| 16 | Thu Jan 5 | at UT Martin | L82-87 | 6-10 | .375 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 17 | Sat Jan 7 | at Little Rock | W74-68 | 7-10 | .412 | - | | Jack Stephens Center · Little Rock, AR |
| 18 | Thu Jan 12 | vs Lindenwood | W94-71 | 8-10 | .444 | - | | Show Me Center · Cape Girardeau, MO |
| 19 | Sat Jan 14 | at Morehead St | W91-86 | 9-10 | .474 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 20 | Thu Jan 19 | vsUT Martin | L60-80 | 9-11 | .450 | - | | Show Me Center · Cape Girardeau, MO |
| 21 | Sat Jan 21 | vs Tennessee Tech | W84-77 (2OT) | 10-11 | .476 | - | | Show Me Center · Cape Girardeau, MO |
| 22 | Thu Jan 26 | vs Tennessee St | W92-75 | 11-11 | .500 | - | | Show Me Center · Cape Girardeau, MO |
| 23 | Sat Jan 28 | at E Illinois | W79-68 | 12-11 | .522 | - | | Lantz Arena · Charleston, IL |
| 24 | Thu Feb 2 | vsLittle Rock | W99-98 | 13-11 | .542 | - | | Show Me Center · Cape Girardeau, MO |
| 25 | Sat Feb 4 | atTennessee Tech | L80-82 | 13-12 | .520 | - | | Hooper Eblen Center · Cookeville, TN |
| 26 | Thu Feb 9 | atTennessee St | L65-85 | 13-13 | .500 | - | | Gentry Center · Nashville, TN |
| 27 | Sat Feb 11 | vsMorehead St | L59-65 | 13-14 | .481 | - | | Show Me Center · Cape Girardeau, MO |
| 28 | Thu Feb 16 | vsE Illinois | W78-64 | 14-14 | .500 | - | | Show Me Center · Cape Girardeau, MO |
| 29 | Sat Feb 18 | vsSo Indiana | W85-80 | 15-14 | .517 | - | | Show Me Center · Cape Girardeau, MO |
| 30 | Thu Feb 23 | atLindenwood | L102-105 (2OT) | 15-15 | .500 | - | | placeholder · sf, ca |
| 31 | Sat Feb 25 | atSIUE | L78-93 | 15-16 | .484 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 32 | Wed Mar 1 | vsLindenwood | W84-65 | 16-16 | .500 | - | | Show Me Center · Cape Girardeau, MO |
| 33 | Thu Mar 2 | atTennessee St | W91-83 | 17-16 | .515 | - | | Gentry Center · Nashville, TN |
| 34 | Fri Mar 3 | atMorehead St | W65-58 | 18-16 | .529 | - | ESPNU | Ellis T. Johnson Arena · Morehead, KY |
| 35 | Sat Mar 4 | atTennessee Tech | W89-82 (OT) | 19-16 | .543 | - | ESPN2 | Hooper Eblen Center · Cookeville, TN |
| 36 | Tue Mar 14 | at #16Texas A&M-CC | L71-75 | 19-17 | .528 | #16 | truTV | American Bank Center · Corpus Christi, TX |
