| 1 | Mon Nov 6 | at Grand Canyon | L67-88 | 0-1 | .000 | - | | GCU Arena · Phoenix, AZ |
| 2 | Fri Nov 10 | at Butler | L56-91 | 0-2 | .000 | - | FS2 | Hinkle Fieldhouse · Indianapolis, IN |
| 3 | Wed Nov 15 | vs Evansville | L57-76 | 0-3 | .000 | - | | Show Me Center · Cape Girardeau, MO |
| 4 | Mon Nov 20 | vs C Arkansas | W70-68 | 1-3 | .250 | - | | Show Me Center · Cape Girardeau, MO |
| 5 | Sat Nov 25 | atEvansville | L74-93 | 1-4 | .200 | - | | Ford Center · Evansville, IN |
| 6 | Sun Nov 26 | at Chattanooga | L56-72 | 1-5 | .167 | - | | McKenzie Arena · Chattanooga, TN |
| 7 | Thu Nov 30 | at Kansas City | L44-74 | 1-6 | .143 | - | | Swinney Recreation Center · Kansas City, MO |
| 8 | Sun Dec 3 | vs TBD | W84-56 | 2-6 | .250 | - | | Show Me Center · Cape Girardeau, MO |
| 9 | Wed Dec 6 | vsTBD | W95-45 | 3-6 | .333 | - | | Show Me Center · Cape Girardeau, MO |
| 10 | Sat Dec 9 | at Purdue FW | L80-89 | 3-7 | .300 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 11 | Sun Dec 17 | vsTBD | W87-59 | 4-7 | .364 | - | | Show Me Center · Cape Girardeau, MO |
| 12 | Thu Dec 21 | at Illinois St | L64-85 | 4-8 | .333 | - | | Redbird Arena · Normal, IL |
| 13 | Fri Dec 29 | vs So Indiana | W93-91 (OT) | 5-8 | .385 | - | | Show Me Center · Cape Girardeau, MO |
| 14 | Sun Dec 31 | vs Morehead St | L64-83 | 5-9 | .357 | - | | Show Me Center · Cape Girardeau, MO |
| 15 | Thu Jan 4 | at W Illinois | L61-68 | 5-10 | .333 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 16 | Sat Jan 6 | vsTBD | W71-61 | 6-10 | .375 | - | | Show Me Center · Cape Girardeau, MO |
| 17 | Thu Jan 11 | vs Lindenwood | L68-74 | 6-11 | .353 | - | | Show Me Center · Cape Girardeau, MO |
| 18 | Sat Jan 13 | at Tennessee Tech | L59-70 | 6-12 | .333 | - | | Hooper Eblen Center · Cookeville, TN |
| 19 | Sat Jan 20 | vs SIUE | W52-47 | 7-12 | .368 | - | | Show Me Center · Cape Girardeau, MO |
| 20 | Thu Jan 25 | at UT Martin | L58-84 | 7-13 | .350 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 21 | Sat Jan 27 | at Little Rock | L61-66 | 7-14 | .333 | - | | Jack Stephens Center · Little Rock, AR |
| 22 | Tue Jan 30 | atLindenwood | L54-58 | 7-15 | .318 | - | | placeholder · sf, ca |
| 23 | Sat Feb 3 | vsW Illinois | L55-76 | 7-16 | .304 | - | | Show Me Center · Cape Girardeau, MO |
| 24 | Thu Feb 8 | vsTennessee Tech | W88-69 | 8-16 | .333 | - | | Show Me Center · Cape Girardeau, MO |
| 25 | Sat Feb 10 | vs Tennessee St | L74-77 | 8-17 | .320 | - | | Show Me Center · Cape Girardeau, MO |
| 26 | Thu Feb 15 | at E Illinois | L57-75 | 8-18 | .308 | - | | Lantz Arena · Charleston, IL |
| 27 | Sat Feb 17 | atSIUE | L76-80 | 8-19 | .296 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 28 | Thu Feb 22 | vsLittle Rock | L61-83 | 8-20 | .286 | - | | Show Me Center · Cape Girardeau, MO |
| 29 | Sat Feb 24 | vsUT Martin | L72-82 | 8-21 | .276 | - | | Show Me Center · Cape Girardeau, MO |
| 30 | Thu Feb 29 | atMorehead St | L50-72 | 8-22 | .267 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 31 | Sat Mar 2 | atSo Indiana | W70-66 | 9-22 | .290 | - | | Screaming Eagles Arena · Evansville, IN |
