| 1 | Mon Nov 4 | at Bradley | L60-88 | 0-1 | .000 | - | ESPN+ | Carver Arena · Peoria, IL |
| 2 | Sun Nov 10 | at Vanderbilt | L76-85 | 0-2 | .000 | - | ESPN+ | Memorial Gymnasium (TN) · Nashville, TN |
| 3 | Wed Nov 13 | vs TBD | W93-38 | 1-2 | .333 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 4 | Sun Nov 17 | vs Chattanooga | L82-87 | 1-3 | .250 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 5 | Thu Nov 21 | at C Arkansas | W77-73 (OT) | 2-3 | .400 | - | ESPN+ | Farris Center · Conway, AR |
| 6 | Fri Nov 22 | vs UNC Asheville | L64-72 | 2-4 | .333 | - | | Show Me Center · Cape Girardeau, MO |
| 7 | Sat Nov 30 | vs Kansas City | W80-59 | 3-4 | .429 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 8 | Thu Dec 5 | at Lipscomb | L60-78 | 3-5 | .375 | - | ESPN+ | Allen Arena · Nashville, TN |
| 9 | Sun Dec 8 | at Murray St | L53-73 | 3-6 | .333 | - | ESPN+ | CFSB Center · Murray, KY |
| 10 | Sun Dec 15 | vsTBD | W93-56 | 4-6 | .400 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 11 | Thu Dec 19 | vs E Illinois | W79-72 | 5-6 | .455 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 12 | Sat Dec 21 | vs SIUE | W80-64 | 6-6 | .500 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 13 | Sun Dec 29 | vsTBD | W88-39 | 7-6 | .538 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 14 | Thu Jan 2 | at Tennessee St | W67-65 | 8-6 | .571 | - | ESPN+ | Gentry Center · Nashville, TN |
| 15 | Sat Jan 4 | at UT Martin | L63-66 | 8-7 | .533 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 16 | Thu Jan 9 | vs So Indiana | W77-66 | 9-7 | .563 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 17 | Sat Jan 11 | vs Morehead St | L56-67 | 9-8 | .529 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 18 | Tue Jan 14 | vs Little Rock | L71-73 | 9-9 | .500 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 19 | Thu Jan 16 | at Tennessee Tech | W77-70 | 10-9 | .526 | - | ESPN+ | Hooper Eblen Center · Cookeville, TN |
| 20 | Thu Jan 23 | at Lindenwood | L68-72 | 10-10 | .500 | - | ESPN+ | placeholder · sf, ca |
| 21 | Sat Jan 25 | at W Illinois | W72-51 | 11-10 | .524 | - | ESPN+ | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 22 | Thu Jan 30 | vsUT Martin | W90-79 | 12-10 | .545 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 23 | Sat Feb 1 | vsTennessee St | W89-87 (OT) | 13-10 | .565 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 24 | Thu Feb 6 | atMorehead St | W80-51 | 14-10 | .583 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 25 | Sat Feb 8 | atSo Indiana | W79-74 | 15-10 | .600 | - | ESPN+ | Screaming Eagles Arena · Evansville, IN |
| 26 | Tue Feb 11 | atLittle Rock | W57-45 | 16-10 | .615 | - | ESPN+ | Jack Stephens Center · Little Rock, AR |
| 27 | Sat Feb 15 | vsTennessee Tech | W83-69 | 17-10 | .630 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 28 | Thu Feb 20 | vsW Illinois | W87-66 | 18-10 | .643 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
