| 1 | Sat Nov 28 | at Kansas City | W71-66 | 1-0 | 1.000 | - | | Swinney Recreation Center · Kansas City, MO |
| 2 | Wed Dec 2 | vsS Illinois | L79-87 (OT) | 1-1 | .500 | - | | Show Me Center · Cape Girardeau, MO |
| 3 | Mon Dec 7 | vsLipscomb | W82-77 | 2-1 | .667 | - | | Show Me Center · Cape Girardeau, MO |
| 4 | Wed Dec 9 | atLipscomb | L74-80 (OT) | 2-2 | .500 | - | | Allen Arena · Nashville, TN |
| 5 | Sat Dec 12 | atUT Martin | PPD | 11-16 | .407 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 6 | Tue Dec 15 | atEvansville | L63-66 (OT) | 2-3 | .400 | - | | Ford Center · Evansville, IN |
| 7 | Fri Dec 18 | vsUT Martin | L67-69 | 2-4 | .333 | - | | Show Me Center · Cape Girardeau, MO |
| 8 | Tue Dec 22 | atIndiana St | L66-72 | 2-5 | .286 | - | | Hulman Center · Terre Haute, IN |
| 9 | Wed Dec 30 | atTennessee Tech | L63-72 | 2-6 | .250 | - | | Hooper Eblen Center · Cookeville, TN |
| 10 | Sat Jan 2 | vsTennessee St | W83-79 (2OT) | 3-6 | .333 | - | | Show Me Center · Cape Girardeau, MO |
| 11 | Thu Jan 7 | atBelmont | L66-77 | 3-7 | .300 | - | | Curb Event Center Arena · Nashville, TN |
| 12 | Mon Jan 11 | atUT Martin | PPD | 11-16 | .407 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 14 | Sat Jan 16 | vsMorehead St | L50-64 | 3-8 | .273 | - | | Show Me Center · Cape Girardeau, MO |
| 15 | Tue Jan 19 | atTennessee St | W63-59 | 4-8 | .333 | - | | Gentry Center · Nashville, TN |
| 16 | Thu Jan 21 | atMorehead St | L65-76 | 4-9 | .308 | - | ESPNU | Ellis T. Johnson Arena · Morehead, KY |
| 18 | Tue Jan 26 | atUT Martin | L66-69 | 4-10 | .286 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 19 | Thu Jan 28 | vsSIUE | W64-62 | 5-10 | .333 | - | | Show Me Center · Cape Girardeau, MO |
| 20 | Sat Jan 30 | vsE Illinois | W75-44 | 6-10 | .375 | - | | Show Me Center · Cape Girardeau, MO |
| 21 | Mon Feb 1 | vsMurray St | L60-77 | 6-11 | .353 | - | | Show Me Center · Cape Girardeau, MO |
| 22 | Thu Feb 4 | vsTennessee Tech | W68-64 | 7-11 | .389 | - | | Show Me Center · Cape Girardeau, MO |
| 23 | Sat Feb 6 | vsJ'Ville St | L54-66 | 7-12 | .368 | - | | Show Me Center · Cape Girardeau, MO |
| 24 | Fri Feb 12 | atMurray St | L60-80 | 7-13 | .350 | - | | CFSB Center · Murray, KY |
| 25 | Sat Feb 13 | atAustin Peay | L63-78 | 7-14 | .333 | - | | Winfield Dunn Center · Clarksville, TN |
| 26 | Tue Feb 16 | vsAustin Peay | W86-81 (OT) | 8-14 | .364 | - | | Show Me Center · Cape Girardeau, MO |
| 28 | Sat Feb 20 | vsE Kentucky | W94-72 | 9-14 | .391 | - | | Show Me Center · Cape Girardeau, MO |
| 29 | Mon Feb 22 | vsE Kentucky | L65-87 | 9-15 | .375 | - | | Show Me Center · Cape Girardeau, MO |
| 30 | Thu Feb 25 | atE Illinois | W94-88 | 10-15 | .400 | - | | Lantz Arena · Charleston, IL |
| 31 | Sat Feb 27 | atSIUE | W69-63 | 11-15 | .423 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 32 | Wed Mar 3 | atMorehead St | L54-61 | 11-16 | .407 | - | | Ford Center · Evansville, IN |
