| 1 | Tue Nov 5 | at North Texas | L63-80 | 0-1 | .000 | - | ESPN+ | The Super Pit · Denton, TX |
| 2 | Sat Nov 9 | vs TBD | W96-49 | 1-1 | .500 | - | ESPN+ | Ford Center · Evansville, IN |
| 3 | Wed Nov 13 | at MTSU | L63-80 | 1-2 | .333 | - | ESPN+ | Murphy Center · Murfreesboro, TN |
| 4 | Sat Nov 16 | vs Radford | L81-92 | 1-3 | .250 | - | ESPN+ | Ford Center · Evansville, IN |
| 5 | Tue Nov 19 | at Ohio State | L30-80 | 1-4 | .200 | - | B1G+ | Value City Arena · Columbus, OH |
| 6 | Fri Nov 22 | vs Green Bay | W98-81 | 2-4 | .333 | - | ESPN+ | Ford Center · Evansville, IN |
| 7 | Sun Nov 24 | vs Campbell | W66-53 | 3-4 | .429 | - | ESPN+ | Ford Center · Evansville, IN |
| 8 | Tue Dec 3 | at Murray St | L61-63 | 3-5 | .375 | - | ESPN+ | CFSB Center · Murray, KY |
| 9 | Sat Dec 7 | vs Western KY | L65-79 | 3-6 | .333 | - | ESPN+ | Ford Center · Evansville, IN |
| 10 | Thu Dec 12 | vs Chattanooga | L67-75 | 3-7 | .300 | - | ESPN+ | Ford Center · Evansville, IN |
| 11 | Wed Dec 18 | at UT Arlington | L54-80 | 3-8 | .273 | - | ESPN+ | College Park Center · Arlington, TX |
| 12 | Sat Dec 21 | at Ball State | L43-80 | 3-9 | .250 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 13 | Sun Dec 29 | vs Missouri St | W57-40 | 4-9 | .308 | - | ESPN+ | Ford Center · Evansville, IN |
| 14 | Wed Jan 1 | at S Illinois | W68-53 | 5-9 | .357 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 15 | Sat Jan 4 | vs Indiana St | L62-66 | 5-10 | .333 | - | ESPN+ | Ford Center · Evansville, IN |
| 16 | Wed Jan 8 | vs Illinois St | W69-51 | 6-10 | .375 | - | ESPN+ | Ford Center · Evansville, IN |
| 17 | Sat Jan 11 | at Drake | L40-63 | 6-11 | .353 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 18 | Tue Jan 14 | at Northern Iowa | L56-73 | 6-12 | .333 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 19 | Sat Jan 18 | vs Belmont | L82-85 | 6-13 | .316 | - | ESPN+ | Ford Center · Evansville, IN |
| 20 | Wed Jan 22 | vs UIC | L67-78 | 6-14 | .300 | - | ESPN+ | Ford Center · Evansville, IN |
| 21 | Sat Jan 25 | at Valparaiso | W78-68 | 7-14 | .333 | - | ESPN+ | Athletics-Recreation Center · Valparaiso, IN |
| 22 | Wed Jan 29 | vsMurray St | W78-74 | 8-14 | .364 | - | ESPN+ | Ford Center · Evansville, IN |
| 23 | Sun Feb 2 | atBelmont | W80-75 | 9-14 | .391 | - | ESPN+ | Curb Event Center Arena · Nashville, TN |
| 24 | Wed Feb 5 | vsS Illinois | L59-68 | 9-15 | .375 | - | ESPN+ | Ford Center · Evansville, IN |
| 25 | Sat Feb 8 | vs Bradley | L74-80 | 9-16 | .360 | - | CBS | Ford Center · Evansville, IN |
| 26 | Wed Feb 12 | atMissouri St | L54-71 | 9-17 | .346 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 27 | Sun Feb 16 | vsValparaiso | W79-69 | 10-17 | .370 | - | ESPN+ | Ford Center · Evansville, IN |
| 28 | Wed Feb 19 | atIndiana St | W79-74 | 11-17 | .393 | - | ESPN+ | Hulman Center · Terre Haute, IN |
