| 1 | Mon Nov 4 | at Memphis | L75-83 | 0-1 | .000 | - | ESPN+ | FedExForum · Memphis, TN |
| 2 | Fri Nov 8 | vs Howard | W77-62 | 1-1 | .500 | - | ESPN+ | Mizzou Arena · Columbia, MO |
| 3 | Mon Nov 11 | vs E Washington | W84-77 | 2-1 | .667 | - | ESPN+ | Mizzou Arena · Columbia, MO |
| 4 | Thu Nov 14 | vs Miss Valley St | W111-39 | 3-1 | .750 | - | ESPN+ | Mizzou Arena · Columbia, MO |
| 5 | Fri Nov 22 | vs Pacific | W91-56 | 4-1 | .800 | - | ESPN+ | Mizzou Arena · Columbia, MO |
| 6 | Sun Nov 24 | vs AR-Pine Bluff | W112-63 | 5-1 | .833 | - | ESPN+ | Mizzou Arena · Columbia, MO |
| 7 | Wed Nov 27 | vs Lindenwood | W81-61 | 6-1 | .857 | - | ESPN+ | Mizzou Arena · Columbia, MO |
| 8 | Tue Dec 3 | vs California | W98-93 | 7-1 | .875 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 9 | Sun Dec 8 | vs #1Kansas | W76-67 | 8-1 | .889 | - | ESPN2 | Mizzou Arena · Columbia, MO |
| 10 | Sat Dec 14 | vs Long Island | W88-61 | 9-1 | .900 | - | ESPN+ | Mizzou Arena · Columbia, MO |
| 11 | Tue Dec 17 | vs J'Ville St | W83-72 | 10-1 | .909 | - | ESPN+ | Mizzou Arena · Columbia, MO |
| 12 | Sun Dec 22 | vs Illinois | L77-80 | 10-2 | .833 | - | ESPN | Mizzou Arena · Columbia, MO |
| 13 | Mon Dec 30 | vs Alabama St | W82-65 | 11-2 | .846 | - | ESPN+ | Mizzou Arena · Columbia, MO |
| 14 | Sat Jan 4 | at #2Auburn | L68-84 | 11-3 | .786 | - | SEC Network | Neville Arena · Auburn, AL |
| 15 | Tue Jan 7 | vs LSU | W83-67 | 12-3 | .800 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 16 | Sat Jan 11 | vs Vanderbilt | W75-66 | 13-3 | .813 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 17 | Tue Jan 14 | at #5Florida | W83-82 | 14-3 | .824 | - | ESPNU | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 18 | Sat Jan 18 | vs Arkansas | W83-65 | 15-3 | .833 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 19 | Tue Jan 21 | at Texas | L53-61 | 15-4 | .789 | #22 | SEC Network | Moody Center · Austin, TX |
| 20 | Sat Jan 25 | vs #16Ole Miss | W83-75 | 16-4 | .800 | #22 | SEC Network | Mizzou Arena · Columbia, MO |
| 21 | Sat Feb 1 | at #14Mississippi St | W88-61 | 17-4 | .810 | #20 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 22 | Wed Feb 5 | at #4Tennessee | L81-85 | 17-5 | .773 | #15 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 23 | Sat Feb 8 | vs #10Texas A&M | L64-67 | 17-6 | .739 | #15 | SEC Network | Mizzou Arena · Columbia, MO |
| 24 | Wed Feb 12 | vs Oklahoma | W82-58 | 18-6 | .750 | #21 | SEC Network | Mizzou Arena · Columbia, MO |
| 25 | Sat Feb 15 | at Georgia | W87-74 | 19-6 | .760 | #21 | SEC Network | Stegeman Coliseum · Athens, GA |
| 26 | Wed Feb 19 | vs #4Alabama | W110-98 | 20-6 | .769 | #15 | SEC Network | Mizzou Arena · Columbia, MO |
South Carolina
#17Kentucky