| 1 | Tue Nov 9 | vs C Michigan | W78-68 | 1-0 | 1.000 | - | | Mizzou Arena · Columbia, MO |
| 2 | Mon Nov 15 | vs Kansas City | L66-80 | 1-1 | .500 | - | | Mizzou Arena · Columbia, MO |
| 3 | Thu Nov 18 | vs N Illinois | W54-37 | 2-1 | .667 | - | | Mizzou Arena · Columbia, MO |
| 4 | Sun Nov 21 | at SMU | W80-75 (OT) | 3-1 | .750 | - | CBS | Moody Coliseum · Dallas, TX |
| 5 | Mon Nov 22 | vs Florida St | L58-81 | 3-2 | .600 | - | | Mizzou Arena · Columbia, MO |
| 6 | Fri Nov 26 | vs Wichita St | L55-61 | 3-3 | .500 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 7 | Mon Nov 29 | vs TBD | W91-59 | 4-3 | .571 | - | | Mizzou Arena · Columbia, MO |
| 8 | Thu Dec 2 | at Liberty | L45-66 | 4-4 | .500 | - | | Liberty Arena · Lynchburg, VA |
| 9 | Tue Dec 7 | vs E Illinois | W72-44 | 5-4 | .556 | - | | Mizzou Arena · Columbia, MO |
| 10 | Sat Dec 11 | at #8Kansas | L65-102 | 5-5 | .500 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 11 | Sat Dec 18 | vs Utah | W83-75 | 6-5 | .545 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 12 | Wed Dec 22 | at Illinois | L63-88 | 6-6 | .500 | - | BTN | State Farm Center · Champaign, IL |
| 13 | Wed Dec 29 | at #18Kentucky | L56-83 | 6-7 | .462 | - | SEC Network | Rupp Arena · Lexington, KY |
| 14 | Wed Jan 5 | vs Mississippi St | PPD | 12-21 | .364 | - | | Mizzou Arena · Columbia, MO |
| 15 | Sat Jan 8 | vs #15Alabama | W92-86 | 7-7 | .500 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 16 | Wed Jan 12 | at Arkansas | L43-87 | 7-8 | .467 | - | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 17 | Sat Jan 15 | vs Texas A&M | L64-67 | 7-9 | .438 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 18 | Tue Jan 18 | at Ole Miss | W78-53 | 8-9 | .471 | - | ESPNU | SJB Pavilion · Oxford, MS |
| 19 | Sat Jan 22 | atAlabama | L76-86 | 8-10 | .444 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 20 | Tue Jan 25 | vs #1Auburn | L54-55 | 8-11 | .421 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 21 | Sat Jan 29 | at Iowa State | L50-67 | 8-12 | .400 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 22 | Wed Feb 2 | vs Florida | L65-66 | 8-13 | .381 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 23 | Sat Feb 5 | atTexas A&M | W70-66 | 9-13 | .409 | - | ESPN2 | Reed Arena · College Station, TX |
| 24 | Tue Feb 8 | at Vanderbilt | L62-70 | 9-14 | .391 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 25 | Sat Feb 12 | vsOle Miss | W74-68 | 10-14 | .417 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 26 | Tue Feb 15 | vs#23Arkansas | L57-76 | 10-15 | .400 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 27 | Fri Feb 18 | atMississippi St | L49-68 | 10-16 | .385 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 28 | Sun Feb 20 | vsMississippi St | L56-58 | 10-17 | .370 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 29 | Tue Feb 22 | vs #17Tennessee | L61-80 | 10-18 | .357 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 30 | Sat Feb 26 | at LSU | L55-75 | 10-19 | .345 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 31 | Tue Mar 1 | at South Carolina | L69-73 | 10-20 | .333 | - | ESPNU | Colonial Life Arena · Columbia, SC |
| 32 | Sat Mar 5 | vs Georgia | W79-69 | 11-20 | .355 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 33 | Wed Mar 9 | vsOle Miss | W72-60 | 12-20 | .375 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 34 | Thu Mar 10 | atLSU | L68-76 | 12-21 | .364 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
