| 1 | Mon Nov 6 | vs AR-Pine Bluff | W101-79 | 1-0 | 1.000 | - | | Mizzou Arena · Columbia, MO |
| 2 | Fri Nov 10 | vs Memphis | L55-70 | 1-1 | .500 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 3 | Mon Nov 13 | vs SIUE | W68-50 | 2-1 | .667 | - | | Mizzou Arena · Columbia, MO |
| 4 | Thu Nov 16 | at Minnesota | W70-68 | 3-1 | .750 | - | BTN | Williams Arena · Minneapolis, MN |
| 5 | Sun Nov 19 | vs Jackson St | L72-73 | 3-2 | .600 | - | | Mizzou Arena · Columbia, MO |
| 6 | Wed Nov 22 | vs SC State | W82-59 | 4-2 | .667 | - | | Mizzou Arena · Columbia, MO |
| 7 | Sat Nov 25 | vs Loyola MD | W78-70 | 5-2 | .714 | - | | Mizzou Arena · Columbia, MO |
| 8 | Tue Nov 28 | at Pitt | W71-64 | 6-2 | .750 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 9 | Sun Dec 3 | vs Wichita St | W82-72 | 7-2 | .778 | - | ESPN2 | Mizzou Arena · Columbia, MO |
| 10 | Sat Dec 9 | at #2Kansas | L64-73 | 7-3 | .700 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 11 | Sun Dec 17 | vs Seton Hall | L87-93 | 7-4 | .636 | - | ESPN | Mizzou Arena · Columbia, MO |
| 12 | Fri Dec 22 | at #13Illinois | L73-97 | 7-5 | .583 | - | FS1 | State Farm Center · Champaign, IL |
| 13 | Sat Dec 30 | vs C Arkansas | W92-59 | 8-5 | .615 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 14 | Sat Jan 6 | vs Georgia | L68-75 | 8-6 | .571 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 15 | Tue Jan 9 | at #6Kentucky | L77-90 | 8-7 | .533 | - | ESPN | Rupp Arena · Lexington, KY |
| 16 | Sat Jan 13 | vs South Carolina | L69-71 (OT) | 8-8 | .500 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 17 | Tue Jan 16 | at Alabama | L75-93 | 8-9 | .471 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 18 | Sat Jan 20 | vs Florida | L67-79 | 8-10 | .444 | - | ESPNU | Mizzou Arena · Columbia, MO |
| 19 | Tue Jan 23 | at Texas A&M | L57-63 | 8-11 | .421 | - | SEC Network | Reed Arena · College Station, TX |
| 20 | Sat Jan 27 | atSouth Carolina | L64-72 | 8-12 | .400 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 21 | Wed Jan 31 | vs Arkansas | L84-91 | 8-13 | .381 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 22 | Sat Feb 3 | at Vanderbilt | L61-68 | 8-14 | .364 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 23 | Wed Feb 7 | vsTexas A&M | L60-79 | 8-15 | .348 | - | ESPN2 | Mizzou Arena · Columbia, MO |
| 24 | Sat Feb 10 | vs Mississippi St | L51-75 | 8-16 | .333 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 25 | Sat Feb 17 | at Ole Miss | L76-79 | 8-17 | .320 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 26 | Tue Feb 20 | vs #5Tennessee | L67-72 | 8-18 | .308 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 27 | Sat Feb 24 | atArkansas | L73-88 | 8-19 | .296 | - | ESPN2 | Bud Walton Arena · Fayetteville, AR |
| 28 | Wed Feb 28 | at#24Florida | L74-83 | 8-20 | .286 | - | SEC Network | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 29 | Sat Mar 2 | vsOle Miss | L78-84 | 8-21 | .276 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 30 | Tue Mar 5 | vs #13Auburn | L74-101 | 8-22 | .267 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 31 | Sat Mar 9 | at LSU | L80-84 | 8-23 | .258 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 32 | Wed Mar 13 | atGeorgia | L59-64 | 8-24 | .250 | - | SEC Network | Stegeman Coliseum · Athens, GA |
