| 1 | Mon Nov 3 | at Howard | W88-67 | 1-0 | 1.000 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 2 | Fri Nov 7 | vsSE Missouri St | W89-84 | 2-0 | 1.000 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 3 | Sun Nov 9 | vsVMI | W106-68 | 3-0 | 1.000 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 4 | Wed Nov 12 | vsMinnesota | W83-60 | 4-0 | 1.000 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 5 | Mon Nov 17 | vsPrairie View | W91-73 | 5-0 | 1.000 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 6 | Thu Nov 20 | vsSouth Dakota | W102-68 | 6-0 | 1.000 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 7 | Tue Nov 25 | vsSC State | W98-66 | 7-0 | 1.000 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 8 | Fri Nov 28 | vsCleveland St | W86-59 | 8-0 | 1.000 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 9 | Tue Dec 2 | atNotre Dame | L71-76 | 8-1 | .889 | - | ESPNU | Purcell Pavilion · South Bend, IN |
| 10 | Sun Dec 7 | at21Kansas | L60-80 | 8-2 | .800 | - | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 11 | Thu Dec 11 | vsAlabama St | W85-77 | 9-2 | .818 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 12 | Sun Dec 14 | vsBethune | W82-60 | 10-2 | .833 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 13 | Mon Dec 22 | at20Illinois | L48-91 | 10-3 | .769 | - | FS1 | State Farm Center · Champaign, IL |
| 14 | Sat Jan 3 | vs22Florida | W76-74 | 11-3 | .786 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 15 | Wed Jan 7 | atKentucky | W73-68 | 12-3 | .800 | - | ESPN2 | Rupp Arena · Lexington, KY |
| 16 | Sat Jan 10 | atOle Miss | L69-76 | 12-4 | .750 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 17 | Wed Jan 14 | vsAuburn | W84-74 | 13-4 | .765 | - | ESPN2 | Mizzou Arena · Columbia, MO |
| 18 | Sat Jan 17 | atLSU | L70-78 | 13-5 | .722 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 19 | Tue Jan 20 | vs21Georgia | L72-74 | 13-6 | .684 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 20 | Sat Jan 24 | vsOklahoma | W88-87 (OT) | 14-6 | .700 | - | ESPN2 | Mizzou Arena · Columbia, MO |
| 21 | Tue Jan 27 | at23Alabama | L64-90 | 14-7 | .667 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 22 | Sat Jan 31 | vsMississippi St | W84-79 | 15-7 | .682 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 23 | Sat Feb 7 | atSouth Carolina | W78-59 | 16-7 | .696 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 24 | Wed Feb 11 | atTexas A&M | W86-85 | 17-7 | .708 | - | SEC Network | Reed Arena · College Station, TX |
| 25 | Sat Feb 14 | vsTexas | L68-85 | 17-8 | .680 | - | ESPN2 | Mizzou Arena · Columbia, MO |
| 26 | Wed Feb 18 | vs19Vanderbilt | W81-80 | 18-8 | .692 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 27 | Sat Feb 21 | at20Arkansas | L86-94 | 18-9 | .667 | - | ESPN | Bud Walton Arena · Fayetteville, AR |
| 28 | Tue Feb 24 | vs22Tennessee | W73-69 | 19-9 | .679 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 29 | Sat Feb 28 | atMississippi St | W88-64 | 20-9 | .690 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
