| 1 | Mon Nov 3 | at Howard | TBD | 12-20 | .375 | - | | Burr Gymnasium · Washington, D.C. |
| 2 | Fri Nov 7 | vsSE Missouri St | 8:00 PM | 21-12 | .636 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 3 | Sun Nov 9 | vsVMI | 2:00 PM | 15-19 | .441 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 4 | Wed Nov 12 | vsMinnesota | 8:00 PM | 15-17 | .469 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 5 | Mon Nov 17 | vsPrairie View | 8:00 PM | 5-27 | .156 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 6 | Thu Nov 20 | vsSouth Dakota | 8:00 PM | 19-14 | .576 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 7 | Tue Nov 25 | vsSC State | 8:00 PM | 20-13 | .606 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 8 | Fri Nov 28 | vsCleveland St | 2:00 PM | 23-13 | .639 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 9 | Tue Dec 2 | atNotre Dame | 9:00 PM | 15-18 | .455 | - | ESPNU | Purcell Pavilion · South Bend, IN |
| 10 | Sun Dec 7 | at#19Kansas | 1:00 PM | 21-13 | .618 | - | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 11 | Thu Dec 11 | vsAlabama St | TBD | 20-16 | .556 | - | | Mizzou Arena · Columbia, MO |
| 12 | Sun Dec 14 | vsBethune | 2:00 PM | 17-16 | .515 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 13 | Mon Dec 22 | at#17Illinois | TBD | 22-13 | .629 | - | | State Farm Center · Champaign, IL |
| 14 | Sat Jan 3 | vs#3Florida | 8:30 PM | 36-4 | .900 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 15 | Wed Jan 7 | at#9Kentucky | 7:00 PM | 24-12 | .667 | - | ESPN2 | Rupp Arena · Lexington, KY |
| 16 | Sat Jan 10 | atOle Miss | 6:00 PM | 24-12 | .667 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 17 | Tue Jan 13 | vs#20Auburn | TBD | 32-6 | .842 | - | | Mizzou Arena · Columbia, MO |
| 18 | Sat Jan 17 | atLSU | 3:30 PM | 14-18 | .438 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 19 | Tue Jan 20 | vsGeorgia | 9:00 PM | 20-13 | .606 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 20 | Sat Jan 24 | vsOklahoma | TBD | 20-14 | .588 | - | | Mizzou Arena · Columbia, MO |
| 21 | Tue Jan 27 | at#15Alabama | 9:00 PM | 28-9 | .757 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 22 | Sat Jan 31 | vsMississippi St | 3:30 PM | 21-13 | .618 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 23 | Sat Feb 7 | atSouth Carolina | 1:00 PM | 12-20 | .375 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 24 | Wed Feb 11 | atTexas A&M | 9:00 PM | 23-11 | .676 | - | SEC Network | Reed Arena · College Station, TX |
| 25 | Sat Feb 14 | vsTexas | TBD | 19-16 | .543 | - | | Mizzou Arena · Columbia, MO |
| 26 | Wed Feb 18 | vsVanderbilt | 9:00 PM | 20-13 | .606 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 27 | Sat Feb 21 | at#14Arkansas | TBD | 22-14 | .611 | - | | Bud Walton Arena · Fayetteville, AR |
| 28 | Tue Feb 24 | vs#18Tennessee | 9:00 PM | 30-8 | .789 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 29 | Sat Feb 28 | atMississippi St | 1:00 PM | 21-13 | .618 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 30 | Tue Mar 3 | atOklahoma | 7:00 PM | 20-14 | .588 | - | ESPNU | Lloyd Noble Center · Norman, OK |
| 31 | Sat Mar 7 | vs#14Arkansas | 12:00 PM | 22-14 | .611 | - | ESPN | Mizzou Arena · Columbia, MO |
