| 1 | Mon Nov 7 | vs So Indiana | W97-91 | 1-0 | 1.000 | - | | Mizzou Arena · Columbia, MO |
| 2 | Fri Nov 11 | vs Penn | W92-85 | 2-0 | 1.000 | - | | Mizzou Arena · Columbia, MO |
| 3 | Sun Nov 13 | vs Lindenwood | W82-53 | 3-0 | 1.000 | - | | Mizzou Arena · Columbia, MO |
| 4 | Tue Nov 15 | vs SIUE | W105-80 | 4-0 | 1.000 | - | | Mizzou Arena · Columbia, MO |
| 5 | Sun Nov 20 | vs Miss Valley St | W83-62 | 5-0 | 1.000 | - | | Mizzou Arena · Columbia, MO |
| 6 | Wed Nov 23 | vs Coast Car | W89-51 | 6-0 | 1.000 | - | | Mizzou Arena · Columbia, MO |
| 7 | Sat Nov 26 | vs Hou Christian | W105-69 | 7-0 | 1.000 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 8 | Tue Nov 29 | at Wichita St | W88-84 (OT) | 8-0 | 1.000 | - | | Charles Koch Arena · Wichita, KS |
| 9 | Sun Dec 4 | vs SE Missouri St | W96-89 | 9-0 | 1.000 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 10 | Sat Dec 10 | vs #6Kansas | L67-95 | 9-1 | .900 | - | ESPN | Mizzou Arena · Columbia, MO |
| 11 | Sat Dec 17 | at UCF | W68-66 | 10-1 | .909 | - | | Addition Financial Arena · Orlando, FL |
| 12 | Thu Dec 22 | vs #16Illinois | W93-71 | 11-1 | .917 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 13 | Wed Dec 28 | vs #19Kentucky | W89-75 | 12-1 | .923 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 14 | Wed Jan 4 | at #13Arkansas | L68-74 | 12-2 | .857 | #20 | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 15 | Sat Jan 7 | vs Vanderbilt | W85-82 | 13-2 | .867 | #20 | CBS | Mizzou Arena · Columbia, MO |
| 16 | Wed Jan 11 | at Texas A&M | L64-82 | 13-3 | .813 | #20 | SEC Network | Reed Arena · College Station, TX |
| 17 | Sat Jan 14 | at Florida | L64-73 | 13-4 | .765 | #20 | SEC Network | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 18 | Wed Jan 18 | vs#25Arkansas | W79-76 | 14-4 | .778 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 19 | Sat Jan 21 | vs #4Alabama | L64-85 | 14-5 | .737 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 20 | Tue Jan 24 | at Ole Miss | W89-77 | 15-5 | .750 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 21 | Sat Jan 28 | vs Iowa State | W78-61 | 16-5 | .762 | - | ESPN2 | Mizzou Arena · Columbia, MO |
| 22 | Wed Feb 1 | vs LSU | W87-77 | 17-5 | .773 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 23 | Sat Feb 4 | at Mississippi St | L52-63 | 17-6 | .739 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 24 | Tue Feb 7 | vs South Carolina | W83-74 | 18-6 | .750 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 25 | Sat Feb 11 | at #6Tennessee | W86-85 | 19-6 | .760 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 26 | Tue Feb 14 | at Auburn | L56-89 | 19-7 | .731 | - | ESPN2 | Neville Arena · Auburn, AL |
| 27 | Sat Feb 18 | vsTexas A&M | L60-69 | 19-8 | .704 | - | ESPN2 | Mizzou Arena · Columbia, MO |
| 28 | Tue Feb 21 | vsMississippi St | W66-64 (OT) | 20-8 | .714 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 29 | Sat Feb 25 | at Georgia | W85-63 | 21-8 | .724 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 30 | Wed Mar 1 | atLSU | W81-76 | 22-8 | .733 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 31 | Sat Mar 4 | vsOle Miss | W82-77 | 23-8 | .742 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 32 | Fri Mar 10 | vsTennessee | W79-71 | 24-8 | .750 | - | ESPN | Mizzou Arena · Columbia, MO |
| 33 | Sat Mar 11 | atAlabama | L61-72 | 24-9 | .727 | - | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 34 | Thu Mar 16 | vs #10Utah State | W76-65 | 25-9 | .735 | #7 | TNT | Mizzou Arena · Columbia, MO |
| 35 | Sat Mar 18 | vs #15Princeton | L63-78 | 25-10 | .714 | #7 | TNT | Mizzou Arena · Columbia, MO |
