| 1 | Wed Nov 25 | vs Oral Roberts | W91-64 | 1-0 | 1.000 | - | | Mizzou Arena · Columbia, MO |
| 2 | Wed Dec 2 | at#21Oregon | W83-75 | 2-0 | 1.000 | - | FS1 | Matthew Knight Arena · Eugene, OR |
| 3 | Sun Dec 6 | atWichita St | W72-62 | 3-0 | 1.000 | - | ESPN2 | Charles Koch Arena · Wichita, KS |
| 4 | Wed Dec 9 | vsLiberty | W69-60 | 4-0 | 1.000 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 5 | Sat Dec 12 | vs#6Illinois | W81-78 | 5-0 | 1.000 | - | ESPNU | Mizzou Arena · Columbia, MO |
| 7 | Tue Dec 22 | vsBradley | W54-53 | 6-0 | 1.000 | #14 | SEC Network | Mizzou Arena · Columbia, MO |
| 8 | Wed Dec 30 | vs#7Tennessee | L53-73 | 6-1 | .857 | #12 | SEC Network | Mizzou Arena · Columbia, MO |
| 9 | Sat Jan 2 | atArkansas | W81-68 | 7-1 | .875 | #12 | CBS | Bud Walton Arena · Fayetteville, AR |
| 10 | Tue Jan 5 | atMississippi St | L63-78 | 7-2 | .778 | #13 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 11 | Sat Jan 16 | atTexas A&M | W68-52 | 8-2 | .800 | #17 | SEC Network | Reed Arena · College Station, TX |
| 12 | Tue Jan 19 | vsSouth Carolina | W81-70 | 9-2 | .818 | #19 | SEC Network | Mizzou Arena · Columbia, MO |
| 13 | Sat Jan 23 | at#6Tennessee | W73-64 | 10-2 | .833 | #19 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 14 | Tue Jan 26 | atAuburn | L82-88 | 10-3 | .769 | #12 | ESPN2 | Neville Arena · Auburn, AL |
| 15 | Sat Jan 30 | vsTCU | W102-98 (OT) | 11-3 | .786 | - | ESPNU | Mizzou Arena · Columbia, MO |
| 16 | Wed Feb 3 | vsKentucky | W75-70 | 12-3 | .800 | #18 | ESPN2 | Mizzou Arena · Columbia, MO |
| 17 | Sat Feb 6 | vs#10Alabama | W68-65 | 13-3 | .813 | #18 | ESPN | Mizzou Arena · Columbia, MO |
| 18 | Wed Feb 10 | atOle Miss | L59-80 | 13-4 | .765 | #10 | SEC Network | SJB Pavilion · Oxford, MS |
| 19 | Sat Feb 13 | vsArkansas | L81-86 (OT) | 13-5 | .722 | - | ESPN2 | Mizzou Arena · Columbia, MO |
| 20 | Tue Feb 16 | atGeorgia | L70-80 | 13-6 | .684 | #20 | SEC Network | Stegeman Coliseum · Athens, GA |
| 21 | Sat Feb 20 | atSouth Carolina | W93-78 | 14-6 | .700 | #20 | ESPN2 | Colonial Life Arena · Columbia, SC |
| 22 | Tue Feb 23 | vsOle Miss | L53-60 | 14-7 | .667 | #24 | SEC Network | Mizzou Arena · Columbia, MO |
| 24 | Wed Mar 3 | atFlorida | W72-70 | 15-7 | .682 | - | SEC Network | O'Connell Center · Gainesville, FL |
| 25 | Sat Mar 6 | vsLSU | L80-86 | 15-8 | .652 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 26 | Thu Mar 11 | vsGeorgia | W73-70 | 16-8 | .667 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 27 | Fri Mar 12 | atArkansas | L64-70 | 16-9 | .640 | - | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 28 | Sat Mar 20 | at#8Oklahoma | L68-72 | 16-10 | .615 | #9 | TNT | Lloyd Noble Center · Norman, OK |
