| 1 | Mon Nov 3 | vs Jackson St | W113-55 | 1-0 | 1.000 | #17 | BTN | State Farm Center · Champaign, IL |
| 2 | Fri Nov 7 | vsFGCU | W113-70 | 2-0 | 1.000 | #17 | Peacock | State Farm Center · Champaign, IL |
| 3 | Tue Nov 11 | vs11Texas Tech | W81-77 | 3-0 | 1.000 | #14 | FS1 | State Farm Center · Champaign, IL |
| 4 | Fri Nov 14 | vsColgate | W84-65 | 4-0 | 1.000 | #14 | B1G+ | State Farm Center · Champaign, IL |
| 5 | Wed Nov 19 | vs11Alabama | L86-90 | 4-1 | .800 | #8 | FS1 | State Farm Center · Champaign, IL |
| 6 | Sat Nov 22 | vsLong Island | W98-58 | 5-1 | .833 | #8 | B1G+ | State Farm Center · Champaign, IL |
| 7 | Mon Nov 24 | vsUT Rio Grande | W87-73 | 6-1 | .857 | #13 | BTN | State Farm Center · Champaign, IL |
| 8 | Fri Nov 28 | at5UConn | L61-74 | 6-2 | .750 | #13 | FOX | Gampel Pavilion · Storrs, CT |
| 9 | Sat Dec 6 | at13Tennessee | W75-62 | 7-2 | .778 | #14 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 10 | Tue Dec 9 | atOhio State | W88-80 | 8-2 | .800 | #13 | Peacock | Value City Arena · Columbus, OH |
| 11 | Sat Dec 13 | vs23Nebraska | L80-83 | 8-3 | .727 | #13 | Peacock | State Farm Center · Champaign, IL |
| 12 | Mon Dec 22 | vsMissouri | W91-48 | 9-3 | .750 | #20 | FS1 | State Farm Center · Champaign, IL |
| 13 | Mon Dec 29 | vsSouthern | W90-55 | 10-3 | .769 | #20 | BTN | State Farm Center · Champaign, IL |
| 14 | Sat Jan 3 | atPenn State | W73-65 | 11-3 | .786 | #20 | BTN | The Palestra · Philadelphia, PA |
| 15 | Thu Jan 8 | vsRutgers | W81-55 | 12-3 | .800 | #16 | BTN | State Farm Center · Champaign, IL |
| 16 | Sun Jan 11 | at19Iowa | W75-69 | 13-3 | .813 | #16 | FOX | Carver-Hawkeye Arena · Iowa City, IA |
| 17 | Wed Jan 14 | atNorthwestern | W79-68 | 14-3 | .824 | #13 | BTN | Welsh-Ryan Arena · Evanston, IL |
| 18 | Sat Jan 17 | vsMinnesota | W77-67 | 15-3 | .833 | #13 | BTN | State Farm Center · Champaign, IL |
| 19 | Wed Jan 21 | vsMaryland | W89-70 | 16-3 | .842 | #11 | BTN | State Farm Center · Champaign, IL |
| 20 | Sat Jan 24 | at4Purdue | W88-82 | 17-3 | .850 | #11 | FOX | Mackey Arena · West Lafayette, IN |
| 21 | Thu Jan 29 | vsWashington | W75-66 | 18-3 | .857 | #9 | FS1 | State Farm Center · Champaign, IL |
| 22 | Sun Feb 1 | at5Nebraska | W78-69 | 19-3 | .864 | #9 | FS1 | Pinnacle Bank Arena · Lincoln, NE |
| 23 | Wed Feb 4 | vsNorthwestern | W84-44 | 20-3 | .870 | #5 | BTN | State Farm Center · Champaign, IL |
| 24 | Sat Feb 7 | at10Michigan St | L82-85 (OT) | 20-4 | .833 | #5 | FOX | Breslin Center · East Lansing, MI |
| 25 | Tue Feb 10 | vsWisconsin | L90-92 (OT) | 20-5 | .800 | #8 | Peacock | State Farm Center · Champaign, IL |
| 26 | Sun Feb 15 | vsIndiana | W71-51 | 21-5 | .808 | #8 | CBS | State Farm Center · Champaign, IL |
| 27 | Wed Feb 18 | atUSC | W101-65 | 22-5 | .815 | #10 | BTN | Galen Center · Los Angeles, CA |
| 28 | Sat Feb 21 | atUCLA | L94-95 (OT) | 22-6 | .786 | #10 | FOX | Pauley Pavilion · Los Angeles, CA |
| 29 | Fri Feb 27 | vs3Michigan | L70-84 | 22-7 | .759 | #10 | FOX | State Farm Center · Champaign, IL |
