| 1 | Mon Nov 4 | vs E Illinois | W112-67 | 1-0 | 1.000 | - | B1G+ | State Farm Center · Champaign, IL |
| 2 | Fri Nov 8 | vs SIUE | W90-58 | 2-0 | 1.000 | - | Peacock | State Farm Center · Champaign, IL |
| 3 | Wed Nov 13 | vs Oakland | W66-54 | 3-0 | 1.000 | - | BTN | State Farm Center · Champaign, IL |
| 4 | Wed Nov 20 | at #8Alabama | L87-100 | 3-1 | .750 | #25 | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 5 | Sat Nov 23 | vs MD-Eastern | W87-40 | 4-1 | .800 | #25 | B1G+ | State Farm Center · Champaign, IL |
| 6 | Mon Nov 25 | vs Little Rock | W92-34 | 5-1 | .833 | - | BTN | State Farm Center · Champaign, IL |
| 7 | Thu Nov 28 | at #19Arkansas | W90-77 | 6-1 | .857 | - | CBS | Bud Walton Arena · Fayetteville, AR |
| 8 | Fri Dec 6 | at Northwestern | L66-70 (OT) | 6-2 | .750 | #19 | BTN | Welsh-Ryan Arena · Evanston, IL |
| 9 | Tue Dec 10 | vs #20Wisconsin | W86-80 | 7-2 | .778 | - | Peacock | State Farm Center · Champaign, IL |
| 10 | Sat Dec 14 | vs #1Tennessee | L64-66 | 7-3 | .700 | - | FOX | State Farm Center · Champaign, IL |
| 11 | Sun Dec 22 | at Missouri | W80-77 | 8-3 | .727 | - | ESPN | Mizzou Arena · Columbia, MO |
| 12 | Sun Dec 29 | vs Chicago St | W117-64 | 9-3 | .750 | #24 | BTN | State Farm Center · Champaign, IL |
| 13 | Thu Jan 2 | at #9Oregon | W109-77 | 10-3 | .769 | #22 | FS1 | Matthew Knight Arena · Eugene, OR |
| 14 | Sun Jan 5 | at Washington | W81-77 | 11-3 | .786 | #22 | BTN | Alaska Airlines Arena · Seattle, WA |
| 15 | Wed Jan 8 | vs Penn State | W91-52 | 12-3 | .800 | #13 | BTN | State Farm Center · Champaign, IL |
| 16 | Sat Jan 11 | vs USC | L72-82 | 12-4 | .750 | #13 | BTN | State Farm Center · Champaign, IL |
| 17 | Tue Jan 14 | at Indiana | W94-69 | 13-4 | .765 | #19 | Peacock | Simon Skjodt Assembly Hall · Bloomington, IN |
| 18 | Sun Jan 19 | at #12Michigan St | L78-80 | 13-5 | .722 | #19 | CBS | Breslin Center · East Lansing, MI |
| 19 | Thu Jan 23 | vs Maryland | L70-91 | 13-6 | .684 | #17 | FS1 | State Farm Center · Champaign, IL |
| 20 | Sun Jan 26 | vsNorthwestern | W83-74 | 14-6 | .700 | #17 | BTN | State Farm Center · Champaign, IL |
| 21 | Thu Jan 30 | at Nebraska | L74-80 (OT) | 14-7 | .667 | #18 | FS1 | Pinnacle Bank Arena · Lincoln, NE |
| 22 | Sun Feb 2 | vs Ohio State | W87-79 | 15-7 | .682 | #18 | CBS | State Farm Center · Champaign, IL |
| 23 | Wed Feb 5 | at Rutgers | L73-82 | 15-8 | .652 | #23 | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 24 | Sat Feb 8 | at Minnesota | W95-74 | 16-8 | .667 | #23 | BTN | Williams Arena · Minneapolis, MN |
| 25 | Tue Feb 11 | vs UCLA | W83-78 | 17-8 | .680 | - | Peacock | State Farm Center · Champaign, IL |
| 26 | Sat Feb 15 | vs#11Michigan St | L65-79 | 17-9 | .654 | - | FOX | State Farm Center · Champaign, IL |
| 27 | Tue Feb 18 | at#11Wisconsin | L74-95 | 17-10 | .630 | - | FS1 | Kohl Center · Madison, WI |
#3Duke
Iowa
#12Michigan
#13Purdue