| 1 | Tue Nov 9 | vs Jackson St | W71-47 | 1-0 | 1.000 | #11 | BTN | State Farm Center · Champaign, IL |
| 2 | Fri Nov 12 | vsArkansas St | W92-53 | 2-0 | 1.000 | #11 | | State Farm Center · Champaign, IL |
| 3 | Mon Nov 15 | atMarquette | L66-67 | 2-1 | .667 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 4 | Mon Nov 22 | atCincinnati | L51-71 | 2-2 | .500 | - | ESPNEWS | T-Mobile Center · Kansas City, MOS |
| 5 | Tue Nov 23 | atKansas St | W72-64 | 3-2 | .600 | - | ESPNEWS | T-Mobile Center · Kansas City, MOS |
| 6 | Fri Nov 26 | vsUT Rio Grande | W94-85 | 4-2 | .667 | #14 | | State Farm Center · Champaign, IL |
| 7 | Mon Nov 29 | vsNotre Dame | W82-72 | 5-2 | .714 | - | ESPN2 | State Farm Center · Champaign, IL |
| 8 | Fri Dec 3 | vsRutgers | W86-51 | 6-2 | .750 | - | ESPN2 | State Farm Center · Champaign, IL |
| 9 | Mon Dec 6 | atIowa | W87-83 | 7-2 | .778 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 10 | Sat Dec 11 | vs11Arizona | L79-83 | 7-3 | .700 | - | FOX | State Farm Center · Champaign, IL |
| 11 | Sat Dec 18 | vsSt Francis PA | W106-48 | 8-3 | .727 | - | BTN | State Farm Center · Champaign, IL |
| 12 | Wed Dec 22 | vsMissouri | W88-63 | 9-3 | .750 | - | BTN | Enterprise Center · St. Louis, MO |
| 14 | Tue Jan 4 | atMinnesota | W76-53 | 10-3 | .769 | - | FS1 | Williams Arena · Minneapolis, MN |
| 15 | Thu Jan 6 | vsMaryland | W76-64 | 11-3 | .786 | - | ESPN2 | State Farm Center · Champaign, IL |
| 16 | Tue Jan 11 | atNebraska | W81-71 | 12-3 | .800 | #25 | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 17 | Fri Jan 14 | vsMichigan | W68-53 | 13-3 | .813 | #25 | FS1 | State Farm Center · Champaign, IL |
| 18 | Mon Jan 17 | vs4Purdue | L88-96 (2OT) | 13-4 | .765 | #17 | FOX | State Farm Center · Champaign, IL |
| 19 | Fri Jan 21 | atMaryland | L65-81 | 13-5 | .722 | #17 | FS1 | XFINITY Center · College Park, MD |
| 20 | Tue Jan 25 | vs10Michigan St | W56-55 | 14-5 | .737 | #24 | ESPN | State Farm Center · Champaign, IL |
| 21 | Sat Jan 29 | atNorthwestern | W59-56 | 15-5 | .750 | #24 | BTN | Welsh-Ryan Arena · Evanston, IL |
| 22 | Wed Feb 2 | vs11Wisconsin | W80-67 | 16-5 | .762 | #18 | BTN | State Farm Center · Champaign, IL |
| 23 | Sat Feb 5 | atIndiana | W74-57 | 17-5 | .773 | #18 | ESPN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 24 | Tue Feb 8 | at3Purdue | L68-84 | 17-6 | .739 | #13 | ESPN | Mackey Arena · West Lafayette, IN |
| 25 | Sun Feb 13 | vsNorthwestern | W73-66 | 18-6 | .750 | #13 | BTN | State Farm Center · Champaign, IL |
| 26 | Wed Feb 16 | atRutgers | L59-70 | 18-7 | .720 | #12 | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 27 | Sat Feb 19 | at19Michigan St | W79-74 | 19-7 | .731 | #12 | ESPN | Breslin Center · East Lansing, MI |
| 28 | Thu Feb 24 | vs22Ohio State | L83-86 | 19-8 | .704 | #15 | FS1 | State Farm Center · Champaign, IL |
| 29 | Sun Feb 27 | atMichigan | W93-85 | 20-8 | .714 | #15 | CBS | Crisler Center · Ann Arbor, MI |
| 30 | Thu Mar 3 | vsPenn State | W60-55 | 21-8 | .724 | #20 | FS1 | State Farm Center · Champaign, IL |
| 31 | Sun Mar 6 | vs24Iowa | W74-72 | 22-8 | .733 | #20 | FS1 | State Farm Center · Champaign, IL |
| 32 | Fri Mar 11 | vsIndiana | L63-65 | 22-9 | .710 | - | BTN | State Farm Center · Champaign, IL |
| 32 | Fri Mar 18 | vs13Chattanooga | W54-53 | 23-9 | .719 | #4 | TNT | State Farm Center · Champaign, IL |
| 33 | Sun Mar 20 | vs5Houston | L53-68 | 23-10 | .697 | #4 | CBS | State Farm Center · Champaign, IL |
