| 1 | Mon Nov 6 | vs E Illinois | W80-52 | 1-0 | 1.000 | #25 | | State Farm Center · Champaign, IL |
| 2 | Fri Nov 10 | vs Oakland | W64-53 | 2-0 | 1.000 | #25 | | State Farm Center · Champaign, IL |
| 3 | Tue Nov 14 | vs #4Marquette | L64-71 | 2-1 | .667 | #23 | FS1 | State Farm Center · Champaign, IL |
| 4 | Fri Nov 17 | vs Valparaiso | W87-64 | 3-1 | .750 | #23 | | State Farm Center · Champaign, IL |
| 5 | Sun Nov 19 | vs Southern | W88-60 | 4-1 | .800 | #23 | BTN | State Farm Center · Champaign, IL |
| 6 | Fri Nov 24 | vs W Illinois | W84-52 | 5-1 | .833 | - | BTN | State Farm Center · Champaign, IL |
| 7 | Sat Dec 2 | at Rutgers | W76-58 | 6-1 | .857 | #24 | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 8 | Tue Dec 5 | vs #11FAU | W98-89 | 7-1 | .875 | #20 | ESPN | State Farm Center · Champaign, IL |
| 9 | Sat Dec 9 | at #17Tennessee | L79-86 | 7-2 | .778 | #20 | CBS | Thompson-Boling Arena · Knoxville, TN |
| 10 | Sun Dec 17 | vs Colgate | W74-57 | 8-2 | .800 | #16 | BTN | State Farm Center · Champaign, IL |
| 11 | Fri Dec 22 | vs Missouri | W97-73 | 9-2 | .818 | #13 | FS1 | State Farm Center · Champaign, IL |
| 12 | Fri Dec 29 | vs Fairleigh | W104-71 | 10-2 | .833 | #11 | BTN | State Farm Center · Champaign, IL |
| 13 | Tue Jan 2 | vs Northwestern | W96-66 | 11-2 | .846 | #9 | BTN | State Farm Center · Champaign, IL |
| 14 | Fri Jan 5 | at #1Purdue | L78-83 | 11-3 | .786 | #9 | FS1 | Mackey Arena · West Lafayette, IN |
| 15 | Thu Jan 11 | vs Michigan St | W71-68 | 12-3 | .800 | #10 | FS1 | State Farm Center · Champaign, IL |
| 16 | Sun Jan 14 | vs Maryland | L67-76 | 12-4 | .750 | #10 | BTN | State Farm Center · Champaign, IL |
| 17 | Thu Jan 18 | at Michigan | W88-73 | 13-4 | .765 | #14 | FS1 | Crisler Center · Ann Arbor, MI |
| 18 | Sun Jan 21 | vsRutgers | W86-63 | 14-4 | .778 | #14 | BTN | State Farm Center · Champaign, IL |
| 19 | Wed Jan 24 | atNorthwestern | L91-96 (OT) | 14-5 | .737 | #10 | BTN | Welsh-Ryan Arena · Evanston, IL |
| 20 | Sat Jan 27 | vs Indiana | W70-62 | 15-5 | .750 | #10 | FOX | State Farm Center · Champaign, IL |
| 21 | Tue Jan 30 | at Ohio State | W87-75 | 16-5 | .762 | #14 | | Value City Arena · Columbus, OH |
| 22 | Sun Feb 4 | vs Nebraska | W87-84 (OT) | 17-5 | .773 | #14 | BTN | State Farm Center · Champaign, IL |
| 23 | Sat Feb 10 | atMichigan St | L80-88 | 17-6 | .739 | #10 | CBS | Breslin Center · East Lansing, MI |
| 24 | Tue Feb 13 | vsMichigan | W97-68 | 18-6 | .750 | #14 | | State Farm Center · Champaign, IL |
| 25 | Sat Feb 17 | atMaryland | W85-80 | 19-6 | .760 | #14 | FOX | XFINITY Center · College Park, MD |
| 26 | Wed Feb 21 | at Penn State | L89-90 | 19-7 | .731 | #12 | BTN | Bryce Jordan Center · University Park, PA |
| 27 | Sat Feb 24 | vs Iowa | W95-85 | 20-7 | .741 | #12 | BTN | State Farm Center · Champaign, IL |
| 28 | Wed Feb 28 | vs Minnesota | W105-97 | 21-7 | .750 | #13 | BTN | State Farm Center · Champaign, IL |
| 29 | Sat Mar 2 | at Wisconsin | W91-83 | 22-7 | .759 | #13 | BTN | Kohl Center · Madison, WI |
| 30 | Tue Mar 5 | vs#3Purdue | L71-77 | 22-8 | .733 | #12 | | State Farm Center · Champaign, IL |
| 31 | Sun Mar 10 | atIowa | W73-61 | 23-8 | .742 | #12 | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 32 | Fri Mar 15 | vsOhio State | W77-74 | 24-8 | .750 | #13 | BTN | State Farm Center · Champaign, IL |
| 33 | Sat Mar 16 | vsNebraska | W98-87 | 25-8 | .758 | #13 | CBS | State Farm Center · Champaign, IL |
| 34 | Sun Mar 17 | vsWisconsin | W93-87 | 26-8 | .765 | #13 | CBS | State Farm Center · Champaign, IL |
| 35 | Thu Mar 21 | vs #14Morehead St | W85-69 | 27-8 | .771 | #3 | truTV | State Farm Center · Champaign, IL |
| 36 | Sat Mar 23 | vs #11Duquesne | W89-63 | 28-8 | .778 | #3 | TNT | State Farm Center · Champaign, IL |
| 37 | Thu Mar 28 | at #2Iowa State | W72-69 | 29-8 | .784 | #3 | TBS | James H. Hilton Coliseum · Ames, IA |
| 38 | Sat Mar 30 | at #1UConn | L52-77 | 29-9 | .763 | #3 | TBS | Gampel Pavilion · Storrs, CT |
