| 1 | Wed Nov 25 | vs NC A&T | W122-60 | 1-0 | 1.000 | #8 | BTN | State Farm Center · Champaign, IL |
| 2 | Thu Nov 26 | vs Chicago St | W97-38 | 2-0 | 1.000 | #8 | BTN | State Farm Center · Champaign, IL |
| 3 | Fri Nov 27 | vs Ohio | W77-75 | 3-0 | 1.000 | #8 | BTN | State Farm Center · Champaign, IL |
| 4 | Wed Dec 2 | at Baylor | L69-82 | 3-1 | .750 | - | ESPN | Ferrell Center · Waco, TX |
| 6 | Tue Dec 8 | at Duke | W83-68 | 4-1 | .800 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 7 | Sat Dec 12 | at Missouri | L78-81 | 4-2 | .667 | #6 | ESPNU | Mizzou Arena · Columbia, MO |
| 8 | Tue Dec 15 | vs Minnesota | W92-65 | 5-2 | .714 | #13 | ESPN2 | State Farm Center · Champaign, IL |
| 9 | Sun Dec 20 | at #19Rutgers | L88-91 | 5-3 | .625 | #13 | ESPN2 | Jersey Mike’s Arena · Piscataway, NJ |
| 10 | Wed Dec 23 | at Penn State | W98-81 | 6-3 | .667 | #18 | BTN | Bryce Jordan Center · University Park, PA |
| 11 | Sat Dec 26 | vs Indiana | W69-60 | 7-3 | .700 | #18 | FS1 | State Farm Center · Champaign, IL |
| 12 | Sat Jan 2 | vs Purdue | W66-58 | 8-3 | .727 | #15 | BTN | State Farm Center · Champaign, IL |
| 13 | Thu Jan 7 | at Northwestern | W81-56 | 9-3 | .750 | #12 | BTN | Welsh-Ryan Arena · Evanston, IL |
| 14 | Sun Jan 10 | vs Maryland | L63-66 | 9-4 | .692 | #12 | | State Farm Center · Champaign, IL |
| 15 | Wed Jan 13 | at Nebraska | PPD | 24-7 | .774 | #14 | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 16 | Sat Jan 16 | vs #21Ohio State | L81-87 | 9-5 | .643 | #14 | | State Farm Center · Champaign, IL |
| 17 | Tue Jan 19 | vsPenn State | W79-65 | 10-5 | .667 | #22 | BTN | State Farm Center · Champaign, IL |
| 18 | Sat Jan 23 | at Michigan St | PPD | 24-7 | .774 | #22 | | Breslin Center · East Lansing, MI |
| 19 | Fri Jan 29 | vs #7Iowa | W80-75 | 11-5 | .688 | #19 | FS1 | State Farm Center · Champaign, IL |
| 20 | Tue Feb 2 | atIndiana | W75-71 (OT) | 12-5 | .706 | #12 | ESPN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 21 | Sat Feb 6 | vs #19Wisconsin | W75-60 | 13-5 | .722 | #12 | | State Farm Center · Champaign, IL |
| 22 | Thu Feb 11 | at #3Michigan | PPD | 24-7 | .774 | #6 | | Crisler Center · Ann Arbor, MI |
| 23 | Fri Feb 12 | atNebraska | W77-72 (OT) | 14-5 | .737 | #6 | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 24 | Tue Feb 16 | vsNorthwestern | W73-66 | 15-5 | .750 | #5 | BTN | State Farm Center · Champaign, IL |
| 25 | Sat Feb 20 | atMinnesota | W94-63 | 16-5 | .762 | #5 | | Williams Arena · Minneapolis, MN |
| 26 | Tue Feb 23 | atMichigan St | L72-81 | 16-6 | .727 | #5 | FS1 | Breslin Center · East Lansing, MI |
| 27 | Thu Feb 25 | vsNebraska | W86-70 | 17-6 | .739 | #5 | BTN | State Farm Center · Champaign, IL |
| 28 | Sat Feb 27 | at#23Wisconsin | W74-69 | 18-6 | .750 | #5 | ESPN | Kohl Center · Madison, WI |
| 29 | Tue Mar 2 | at#2Michigan | W76-53 | 19-6 | .760 | #4 | ESPN | Crisler Center · Ann Arbor, MI |
| 30 | Sat Mar 6 | at#7Ohio State | W73-68 | 20-6 | .769 | #4 | ESPN | Value City Arena · Columbus, OH |
| 31 | Fri Mar 12 | vsRutgers | W90-68 | 21-6 | .778 | - | BTN | State Farm Center · Champaign, IL |
| 32 | Sat Mar 13 | vsIowa | W82-71 | 22-6 | .786 | - | CBS | State Farm Center · Champaign, IL |
| 33 | Sun Mar 14 | vsOhio State | W91-88 (OT) | 23-6 | .793 | - | CBS | State Farm Center · Champaign, IL |
| 34 | Fri Mar 19 | vs #16Drexel | W78-49 | 24-6 | .800 | #1 | TBS | State Farm Center · Champaign, IL |
| 35 | Sun Mar 21 | vs #8Loyola Chicago | L58-71 | 24-7 | .774 | #1 | CBS | State Farm Center · Champaign, IL |
