| 1 | Mon Nov 7 | vs E Illinois | W87-57 | 1-0 | 1.000 | #23 | ESPNU | State Farm Center · Champaign, IL |
| 2 | Fri Nov 11 | vs Kansas City | W86-48 | 2-0 | 1.000 | #23 | BTN | State Farm Center · Champaign, IL |
| 3 | Mon Nov 14 | vs Monmouth | W103-65 | 3-0 | 1.000 | #19 | BTN | State Farm Center · Champaign, IL |
| 4 | Fri Nov 18 | at UCLA | W79-70 | 4-0 | 1.000 | - | ESPNU | Pauley Pavilion · Los Angeles, CA |
| 5 | Sun Nov 20 | at Virginia | L61-70 | 4-1 | .800 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 6 | Fri Nov 25 | vs Lindenwood | W92-59 | 5-1 | .833 | #16 | | State Farm Center · Champaign, IL |
| 7 | Tue Nov 29 | vs Syracuse | W73-44 | 6-1 | .857 | - | ESPN | State Farm Center · Champaign, IL |
| 8 | Fri Dec 2 | at #22Maryland | L66-71 | 6-2 | .750 | #16 | BTN | XFINITY Center · College Park, MD |
| 9 | Tue Dec 6 | at Texas | W85-78 (OT) | 7-2 | .778 | - | ESPN | Moody Center · Austin, TX |
| 10 | Sat Dec 10 | vs Penn State | L59-74 | 7-3 | .700 | #17 | BTN | State Farm Center · Champaign, IL |
| 11 | Sat Dec 17 | vs Alabama A&M | W68-47 | 8-3 | .727 | #18 | BTN | State Farm Center · Champaign, IL |
| 12 | Thu Dec 22 | at Missouri | L71-93 | 8-4 | .667 | #16 | SEC Network | Mizzou Arena · Columbia, MO |
| 13 | Thu Dec 29 | vs Bethune | W85-52 | 9-4 | .692 | - | FS1 | State Farm Center · Champaign, IL |
| 14 | Wed Jan 4 | at Northwestern | L60-73 | 9-5 | .643 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 15 | Sat Jan 7 | vs #14Wisconsin | W79-69 | 10-5 | .667 | - | ESPN2 | State Farm Center · Champaign, IL |
| 16 | Tue Jan 10 | at Nebraska | W76-50 | 11-5 | .688 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 17 | Fri Jan 13 | vs Michigan St | W75-66 | 12-5 | .706 | - | FS1 | State Farm Center · Champaign, IL |
| 18 | Mon Jan 16 | at Minnesota | W78-60 | 13-5 | .722 | - | BTN | Williams Arena · Minneapolis, MN |
| 19 | Thu Jan 19 | vs Indiana | L65-80 | 13-6 | .684 | - | FS1 | State Farm Center · Champaign, IL |
| 20 | Tue Jan 24 | vs Ohio State | W69-60 | 14-6 | .700 | - | ESPN | State Farm Center · Champaign, IL |
| 21 | Sat Jan 28 | atWisconsin | W61-51 | 15-6 | .714 | - | FOX | Kohl Center · Madison, WI |
| 22 | Tue Jan 31 | vsNebraska | W72-56 | 16-6 | .727 | - | BTN | State Farm Center · Champaign, IL |
| 23 | Sat Feb 4 | at Iowa | L79-81 | 16-7 | .696 | - | FOX | Carver-Hawkeye Arena · Iowa City, IA |
| 24 | Tue Feb 7 | vsMinnesota | PPD | 20-13 | .606 | - | | State Farm Center · Champaign, IL |
| 25 | Sat Feb 11 | vs #24Rutgers | W69-60 | 17-7 | .708 | - | FS1 | State Farm Center · Champaign, IL |
| 26 | Tue Feb 14 | atPenn State | L81-93 | 17-8 | .680 | - | ESPNU | Bryce Jordan Center · University Park, PA |
| 27 | Sat Feb 18 | at#14Indiana | L68-71 | 17-9 | .654 | - | ESPN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 28 | Mon Feb 20 | vsMinnesota | W78-69 | 18-9 | .667 | - | BTN | State Farm Center · Champaign, IL |
| 29 | Thu Feb 23 | vs#21Northwestern | W66-62 | 19-9 | .679 | - | BTN | State Farm Center · Champaign, IL |
| 30 | Sun Feb 26 | atOhio State | L60-72 | 19-10 | .655 | - | CBS | Value City Arena · Columbus, OH |
| 31 | Thu Mar 2 | vs Michigan | W91-87 (2OT) | 20-10 | .667 | - | ESPN | State Farm Center · Champaign, IL |
| 32 | Sun Mar 5 | at #5Purdue | L71-76 | 20-11 | .645 | - | FOX | Mackey Arena · West Lafayette, IN |
| 33 | Thu Mar 9 | vsPenn State | L76-79 | 20-12 | .625 | - | BTN | State Farm Center · Champaign, IL |
| 34 | Thu Mar 16 | at #8Arkansas | L63-73 | 20-13 | .606 | #9 | TBS | Bud Walton Arena · Fayetteville, AR |
