| 1 | Mon Nov 4 | vs Lipscomb | L72-77 | 0-1 | .000 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 2 | Fri Nov 8 | vs Princeton | L68-75 | 0-2 | .000 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 3 | Fri Nov 15 | at DePaul | L58-84 | 0-3 | .000 | - | FS2 | Wintrust Arena · Chicago, IL |
| 4 | Tue Nov 19 | vs Milwaukee | L74-80 | 0-4 | .000 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 5 | Sun Nov 24 | vs S Dakota St | L60-71 | 0-5 | .000 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 6 | Mon Nov 25 | vs Hampton | L59-64 | 0-6 | .000 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 7 | Tue Nov 26 | at Old Dominion | W67-54 | 1-6 | .143 | - | | Chartway Arena · Norfolk, VA |
| 8 | Tue Dec 3 | vs Saint Peter's | L59-62 | 1-7 | .125 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 9 | Fri Dec 6 | vs Delaware | W80-66 | 2-7 | .222 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 10 | Wed Dec 11 | vs Maine | L56-61 | 2-8 | .200 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 11 | Sat Dec 14 | vs Towson | W65-47 | 3-8 | .273 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 12 | Sat Dec 21 | vs UC Irvine | W70-54 | 4-8 | .333 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 13 | Fri Dec 27 | vs TBD | W93-45 | 5-8 | .385 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 14 | Tue Dec 31 | vs Rhode Island | W67-55 | 6-8 | .429 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 15 | Sat Jan 4 | at Davidson | L71-77 | 6-9 | .400 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 16 | Wed Jan 8 | vs Saint Joseph's | W85-81 (OT) | 7-9 | .438 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 17 | Wed Jan 15 | at G Washington | W73-65 | 8-9 | .471 | - | ESPN+ | Charles E. Smith Center · Washington, D.C. |
| 18 | Sat Jan 18 | vs St Bonaventure | W75-57 | 9-9 | .500 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 19 | Tue Jan 21 | vs Dayton | L62-82 | 9-10 | .474 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 20 | Sun Jan 26 | at Fordham | L63-65 | 9-11 | .450 | - | USA Net | Rose Hill Gymnasium · Bronx, NY |
| 21 | Wed Jan 29 | atSaint Joseph's | L72-76 | 9-12 | .429 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 22 | Sat Feb 1 | vs UMass | L53-62 | 9-13 | .409 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 23 | Wed Feb 5 | at Richmond | L68-73 | 9-14 | .391 | - | ESPN+ | Robins Center · Richmond, VA |
| 24 | Sat Feb 8 | vs Loyola Chicago | W69-56 | 10-14 | .417 | - | CBS | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 25 | Sat Feb 15 | atDayton | L76-77 | 10-15 | .400 | - | USA Net | UD Arena · Dayton, OH |
| 26 | Wed Feb 19 | vsFordham | W73-64 | 11-15 | .423 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 27 | Sat Feb 22 | atSt Bonaventure | L63-70 | 11-16 | .407 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 28 | Wed Feb 26 | at La Salle | W67-62 | 12-16 | .429 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 29 | Sat Mar 1 | vs George Mason | W85-68 | 13-16 | .448 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 30 | Tue Mar 4 | vs VCU | L62-71 | 13-17 | .433 | - | CBS | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 31 | Sat Mar 8 | at Saint Louis | L88-90 (OT) | 13-18 | .419 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 32 | Thu Mar 13 | atSt Bonaventure | L59-64 | 13-19 | .406 | - | USA Net | Reilly Center · Saint Bonaventure, NY |
