| 9 | Sat Dec 6 | vs Stony Brook | 2:00 PM | 6-2 | .750 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 10 | Wed Dec 10 | atBoise St | 9:00 PM | 5-3 | .625 | - | | ExtraMile Arena · Boise, ID |
| 11 | Sat Dec 13 | atNevada | 10:00 PM | 6-3 | .667 | - | | Lawlor Events Center · Reno, NV |
| 12 | Mon Dec 22 | vsCanisius | 7:00 PM | 4-4 | .500 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 13 | Sat Dec 27 | vsTBD | 2:00 PM | 0-0 | .000 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 14 | Tue Dec 30 | atDavidson | 7:00 PM | 6-1 | .857 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 15 | Sat Jan 3 | vsVCU | 12:00 PM | 5-3 | .625 | - | USA Net | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 16 | Wed Jan 7 | atSaint Joseph's | 7:00 PM | 4-3 | .571 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 17 | Tue Jan 13 | vsDayton | 7:00 PM | 7-2 | .778 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 18 | Sat Jan 17 | atFordham | 12:30 PM | 6-3 | .667 | - | | Rose Hill Gymnasium · Bronx, NY |
| 19 | Tue Jan 20 | vsSaint Louis | 7:00 PM | 7-1 | .875 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 20 | Sat Jan 24 | atLoyola Chicago | 2:00 PM | 2-7 | .222 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 21 | Wed Jan 28 | vsSt Bonaventure | 7:00 PM | 8-1 | .889 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 22 | Sun Feb 1 | vsRhode Island | 12:00 PM | 7-2 | .778 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 23 | Wed Feb 4 | atGeorge Mason | 7:00 PM | 9-0 | 1.000 | - | ESPN+ | EagleBank Arena · Fairfax, VA |
| 24 | Sat Feb 7 | vsG Washington | 2:00 PM | 7-2 | .778 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 25 | Sat Feb 14 | atSt Bonaventure | 4:00 PM | 8-1 | .889 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 26 | Wed Feb 18 | vsLa Salle | 7:00 PM | 3-6 | .333 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 27 | Sat Feb 21 | atDayton | 2:00 PM | 7-2 | .778 | - | ESPN+ | UD Arena · Dayton, OH |
| 28 | Wed Feb 25 | vsDavidson | 7:00 PM | 6-1 | .857 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 29 | Sat Feb 28 | atSaint Louis | 8:00 PM | 7-1 | .875 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 30 | Wed Mar 4 | atRhode Island | 7:00 PM | 7-2 | .778 | - | ESPN+ | Ryan Center · Kingston, RI |
| 31 | Sat Mar 7 | vsRichmond | 2:00 PM | 7-1 | .875 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
