| 1 | Mon Nov 3 | vs Niagara | W83-63 | 1-0 | 1.000 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 2 | Fri Nov 7 | vsSacred Heart | W92-80 | 2-0 | 1.000 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 3 | Tue Nov 11 | vsQueens | W87-81 (OT) | 3-0 | 1.000 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 4 | Sat Nov 15 | atVillanova | L77-87 | 3-1 | .750 | - | truTV | Finneran Pavilion · Villanova, PA |
| 5 | Wed Nov 19 | vsLoyola MD | W92-78 | 4-1 | .800 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 6 | Sat Nov 22 | vsNortheastern | L86-93 | 4-2 | .667 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 7 | Wed Nov 26 | vsTBD | W101-80 | 5-2 | .714 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 8 | Tue Dec 2 | vsWilliam & Mary | L79-83 | 5-3 | .625 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 9 | Sat Dec 6 | vsStony Brook | W84-75 | 6-3 | .667 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 10 | Wed Dec 10 | atBoise St | L64-86 | 6-4 | .600 | - | | ExtraMile Arena · Boise, ID |
| 11 | Sat Dec 13 | atNevada | L75-78 | 6-5 | .545 | - | | Lawlor Events Center · Reno, NV |
| 12 | Mon Dec 22 | vsCanisius | W103-59 | 7-5 | .583 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 13 | Sat Dec 27 | vsTBD | W99-49 | 8-5 | .615 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 14 | Tue Dec 30 | atDavidson | W89-83 (2OT) | 9-5 | .643 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 15 | Sat Jan 3 | vsVCU | L80-93 | 9-6 | .600 | - | USA Net | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 16 | Wed Jan 7 | atSaint Joseph's | L90-97 (OT) | 9-7 | .563 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 17 | Tue Jan 13 | vsDayton | L65-71 | 9-8 | .529 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 18 | Sat Jan 17 | atFordham | W74-63 | 10-8 | .556 | - | USA Net | Rose Hill Gymnasium · Bronx, NY |
| 19 | Tue Jan 20 | vs24Saint Louis | L77-81 | 10-9 | .526 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 20 | Sat Jan 24 | atLoyola Chicago | W71-59 | 11-9 | .550 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 21 | Wed Jan 28 | vsSt Bonaventure | L79-87 | 11-10 | .524 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 22 | Sun Feb 1 | vsRhode Island | W76-61 | 12-10 | .545 | - | USA Net | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 23 | Wed Feb 4 | atGeorge Mason | W71-65 | 13-10 | .565 | - | ESPN+ | EagleBank Arena · Fairfax, VA |
| 24 | Sat Feb 7 | vsG Washington | W88-86 | 14-10 | .583 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 25 | Sat Feb 14 | atSt Bonaventure | W78-73 | 15-10 | .600 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 26 | Wed Feb 18 | vsLa Salle | W62-61 | 16-10 | .615 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 27 | Sat Feb 21 | atDayton | L66-78 | 16-11 | .593 | - | ESPN+ | UD Arena · Dayton, OH |
| 28 | Wed Feb 25 | vsDavidson | L56-67 | 16-12 | .571 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 29 | Sat Feb 28 | at23Saint Louis | L76-91 | 16-13 | .552 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
