| 1 | Mon Nov 6 | vs Cleveland St | W79-77 | 1-0 | 1.000 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 2 | Fri Nov 10 | vs Charleston | W90-72 | 2-0 | 1.000 | - | CBS | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 3 | Mon Nov 13 | vs Stony Brook | W85-63 | 3-0 | 1.000 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 4 | Wed Nov 15 | vs Princeton | L67-70 | 3-1 | .750 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 5 | Fri Nov 17 | vs Rider | W77-58 | 4-1 | .800 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 6 | Wed Nov 22 | at Nebraska | L79-89 | 4-2 | .667 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 7 | Wed Nov 29 | vs UC Irvine | W66-62 | 5-2 | .714 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 8 | Wed Dec 6 | at Marshall | W85-72 | 6-2 | .750 | - | | Cam Henderson Center · Huntington, WV |
| 9 | Fri Dec 8 | vs Saint Peter's | W68-59 | 7-2 | .778 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 10 | Mon Dec 18 | vs Bradley | W69-67 | 8-2 | .800 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 11 | Sat Dec 23 | at Santa Clara | L73-81 | 8-3 | .727 | - | | Leavey Center · Santa Clara, CA |
| 12 | Sat Dec 30 | vs TBD | W95-47 | 9-3 | .750 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 13 | Wed Jan 3 | at UMass | L61-80 | 9-4 | .692 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 14 | Sat Jan 6 | at Loyola Chicago | L67-72 | 9-5 | .643 | - | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 15 | Fri Jan 12 | vs Dayton | L62-72 | 9-6 | .600 | - | ESPN2 | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 16 | Tue Jan 16 | vs Richmond | L61-63 | 9-7 | .563 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 17 | Sat Jan 20 | at Saint Joseph's | L69-71 | 9-8 | .529 | - | USA Net | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 18 | Tue Jan 23 | vs St Bonaventure | W54-50 | 10-8 | .556 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 19 | Sat Jan 27 | vs Fordham | W68-59 | 11-8 | .579 | - | USA Net | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 20 | Wed Jan 31 | vs Chicago St | W65-60 | 12-8 | .600 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 21 | Sat Feb 3 | at Rhode Island | W85-71 | 13-8 | .619 | - | USA Net | Ryan Center · Kingston, RI |
| 22 | Wed Feb 7 | vs Davidson | L59-72 | 13-9 | .591 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 23 | Sat Feb 10 | atSt Bonaventure | W75-69 | 14-9 | .609 | - | ESPNU | Reilly Center · Saint Bonaventure, NY |
| 24 | Tue Feb 13 | at#16Dayton | L59-75 | 14-10 | .583 | - | | UD Arena · Dayton, OH |
| 25 | Sat Feb 17 | vsSaint Joseph's | W66-56 | 15-10 | .600 | - | USA Net | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 26 | Tue Feb 20 | vs Saint Louis | W81-66 | 16-10 | .615 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 27 | Fri Feb 23 | atFordham | L67-79 | 16-11 | .593 | - | ESPN2 | Rose Hill Gymnasium · Bronx, NY |
| 28 | Wed Feb 28 | vs La Salle | W75-63 | 17-11 | .607 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 29 | Sat Mar 2 | at George Mason | W59-51 | 18-11 | .621 | - | | EagleBank Arena · Fairfax, VA |
| 30 | Tue Mar 5 | at VCU | W69-59 | 19-11 | .633 | - | | Stuart C. Siegel Center · Richmond, VA |
| 31 | Sat Mar 9 | vs G Washington | W67-65 | 20-11 | .645 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 32 | Wed Mar 13 | vsSaint Louis | W83-73 | 21-11 | .656 | - | USA Net | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 33 | Thu Mar 14 | at#24Dayton | W65-57 | 22-11 | .667 | - | USA Net | UD Arena · Dayton, OH |
| 34 | Sat Mar 16 | vsSt Bonaventure | W70-60 | 23-11 | .676 | - | CBS | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 35 | Sun Mar 17 | atVCU | W57-51 | 24-11 | .686 | - | CBS | Stuart C. Siegel Center · Richmond, VA |
| 36 | Thu Mar 21 | at #6BYU | W71-67 | 25-11 | .694 | #11 | truTV | Marriott Center · Provo, UT |
| 37 | Sat Mar 23 | at #3Illinois | L63-89 | 25-12 | .676 | #11 | TNT | State Farm Center · Champaign, IL |
