| 1 | Mon Nov 4 | vs Navy | W70-63 | 1-0 | 1.000 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 2 | Fri Nov 8 | vs C Connecticut | L67-73 | 1-1 | .500 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 3 | Tue Nov 12 | vs Villanova | W83-76 | 2-1 | .667 | - | CBS | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 4 | Fri Nov 15 | at Penn | W86-69 | 3-1 | .750 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 5 | Thu Nov 21 | vs Texas Tech | W78-77 | 4-1 | .800 | - | ESPN2 | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 6 | Fri Nov 22 | vs Texas | L58-67 | 4-2 | .667 | - | ESPNU | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 7 | Tue Nov 26 | vs Coppin St | W83-54 | 5-2 | .714 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 8 | Tue Dec 3 | vs Princeton | L69-77 | 5-3 | .625 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 9 | Sat Dec 7 | at La Salle | W82-68 | 6-3 | .667 | - | | Tom Gola Arena · Philadelphia, PA |
| 10 | Tue Dec 10 | vs Charleston | L75-78 | 6-4 | .600 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 11 | Wed Dec 18 | vs American | W84-57 | 7-4 | .636 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 12 | Sat Dec 21 | vs Virginia Tech | W82-62 | 8-4 | .667 | - | CBS | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 13 | Sat Dec 28 | vs Delaware St | W76-58 | 9-4 | .692 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 14 | Tue Dec 31 | vs UMass | W81-72 | 10-4 | .714 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 15 | Fri Jan 3 | at Saint Louis | L57-73 | 10-5 | .667 | - | ESPN2 | Chaifetz Arena · St. Louis, MO |
| 16 | Wed Jan 8 | at Duquesne | L81-85 (OT) | 10-6 | .625 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 17 | Sat Jan 11 | vs Loyola Chicago | W93-57 | 11-6 | .647 | - | CBS | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 18 | Fri Jan 17 | vs VCU | L69-78 | 11-7 | .611 | - | ESPNU | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 19 | Tue Jan 21 | at Davidson | W78-61 | 12-7 | .632 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 20 | Fri Jan 24 | at Dayton | L72-77 | 12-8 | .600 | - | ESPN2 | UD Arena · Dayton, OH |
| 21 | Wed Jan 29 | vsDuquesne | W76-72 | 13-8 | .619 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 22 | Sat Feb 1 | atLoyola Chicago | L55-58 | 13-9 | .591 | - | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 23 | Fri Feb 7 | vsSaint Louis | W76-63 | 14-9 | .609 | - | ESPNU | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 24 | Wed Feb 12 | vsLa Salle | W75-63 | 15-9 | .625 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 25 | Sat Feb 15 | at George Mason | L57-58 | 15-10 | .600 | - | | EagleBank Arena · Fairfax, VA |
| 26 | Wed Feb 19 | at G Washington | W79-68 | 16-10 | .615 | - | ESPN+ | Charles E. Smith Center · Washington, D.C. |
| 27 | Sat Feb 22 | vs Richmond | W78-62 | 17-10 | .630 | - | USA Net | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 28 | Wed Feb 26 | vs St Bonaventure | W75-64 | 18-10 | .643 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 29 | Sat Mar 1 | at Fordham | W90-76 | 19-10 | .655 | - | USA Net | Rose Hill Gymnasium · Bronx, NY |
| 30 | Wed Mar 5 | vs Rhode Island | W91-74 | 20-10 | .667 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 31 | Sat Mar 8 | atLa Salle | L74-81 | 20-11 | .645 | - | | Tom Gola Arena · Philadelphia, PA |
| 32 | Thu Mar 13 | vsLa Salle | W75-70 | 21-11 | .656 | - | USA Net | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 33 | Fri Mar 14 | atDayton | W73-68 (OT) | 22-11 | .667 | - | Peacock | UD Arena · Dayton, OH |
| 34 | Sat Mar 15 | atGeorge Mason | L64-74 | 22-12 | .647 | - | CBS | EagleBank Arena · Fairfax, VA |
| 35 | Wed Mar 19 | vs UAB | L65-69 | 22-13 | .629 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
