| 1 | Mon Nov 6 | vs Lafayette | W81-60 | 1-0 | 1.000 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 2 | Fri Nov 10 | vs Penn | W69-61 | 2-0 | 1.000 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 3 | Tue Nov 14 | vs Stonehill | W100-56 | 3-0 | 1.000 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 4 | Fri Nov 17 | vs E Texas A&M | L54-57 | 3-1 | .750 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 5 | Mon Nov 20 | at #16Kentucky | L88-96 (OT) | 3-2 | .600 | - | SEC Network | Rupp Arena · Lexington, KY |
| 6 | Sun Nov 26 | vs Sacred Heart | W64-55 | 4-2 | .667 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 7 | Wed Nov 29 | at #18Villanova | W78-65 | 5-2 | .714 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 8 | Sat Dec 2 | vs Temple | W74-65 | 6-2 | .750 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 9 | Wed Dec 6 | vs American | W69-53 | 7-2 | .778 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 10 | Sun Dec 10 | vs Princeton | W74-70 | 8-2 | .800 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 11 | Sat Dec 16 | at Iona | W83-58 | 9-2 | .818 | - | | Hynes Athletics Center · New Rochelle, NY |
| 12 | Thu Dec 21 | at Charleston | L82-89 | 9-3 | .750 | - | | TD Arena · Charleston, SC |
| 13 | Fri Dec 29 | vs Loyola MD | W97-56 | 10-3 | .769 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 14 | Wed Jan 3 | at Rhode Island | L74-78 | 10-4 | .714 | - | | Ryan Center · Kingston, RI |
| 15 | Wed Jan 10 | at Saint Louis | L85-88 | 10-5 | .667 | - | CBS | Chaifetz Arena · St. Louis, MO |
| 16 | Sat Jan 13 | vs Loyola Chicago | L75-78 | 10-6 | .625 | - | ESPNU | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 17 | Mon Jan 15 | vs La Salle | W82-62 | 11-6 | .647 | - | CBS | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 18 | Sat Jan 20 | vs Duquesne | W71-69 | 12-6 | .667 | - | USA Net | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 19 | Tue Jan 23 | at UMass | W78-77 | 13-6 | .684 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 20 | Fri Jan 26 | at St Bonaventure | L72-91 | 13-7 | .650 | - | ESPN2 | Reilly Center · Saint Bonaventure, NY |
| 21 | Wed Jan 31 | vs George Mason | W75-73 | 14-7 | .667 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 22 | Sat Feb 3 | atLa Salle | W88-82 | 15-7 | .682 | - | ESPNU | Tom Gola Arena · Philadelphia, PA |
| 23 | Tue Feb 6 | vs #18Dayton | L79-94 | 15-8 | .652 | - | CBS | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 24 | Sat Feb 10 | vsSaint Louis | W87-86 | 16-8 | .667 | - | USA Net | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 25 | Wed Feb 14 | atLoyola Chicago | L59-64 | 16-9 | .640 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 26 | Sat Feb 17 | atDuquesne | L56-66 | 16-10 | .615 | - | USA Net | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 27 | Wed Feb 21 | vs G Washington | W79-75 | 17-10 | .630 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 28 | Sun Feb 25 | at VCU | L69-73 | 17-11 | .607 | - | CBS | Stuart C. Siegel Center · Richmond, VA |
| 29 | Sat Mar 2 | vs Fordham | W82-69 | 18-11 | .621 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 30 | Wed Mar 6 | at Richmond | L66-73 | 18-12 | .600 | - | | Robins Center · Richmond, VA |
| 31 | Sat Mar 9 | vs Davidson | W89-71 | 19-12 | .613 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 32 | Wed Mar 13 | atGeorge Mason | W64-57 | 20-12 | .625 | - | USA Net | EagleBank Arena · Fairfax, VA |
| 33 | Thu Mar 14 | atRichmond | W66-61 | 21-12 | .636 | - | USA Net | Robins Center · Richmond, VA |
| 34 | Sat Mar 16 | atVCU | L60-66 | 21-13 | .618 | - | CBS | Stuart C. Siegel Center · Richmond, VA |
| 35 | Wed Mar 20 | at Seton Hall | L72-75 (OT) | 21-14 | .600 | - | ESPN2 | Prudential Center · Newark, NJ |
