| 1 | Tue Nov 5 | vs Bradley | W86-81 | 1-0 | 1.000 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 2 | Sun Nov 10 | at Old Dominion | L69-82 | 1-1 | .500 | - | | Chartway Arena · Norfolk, VA |
| 3 | Wed Nov 13 | at UConn | W96-87 | 2-1 | .667 | - | CBS | Gampel Pavilion · Storrs, CT |
| 4 | Sat Nov 16 | at Loyola Chicago | L68-85 | 2-2 | .500 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 5 | Thu Nov 21 | vs Florida | L62-70 | 2-3 | .400 | - | ESPN2 | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 6 | Fri Nov 22 | vs Missouri St | L69-71 | 2-4 | .333 | - | ESPNU | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 7 | Sun Nov 24 | at Towson | L64-76 | 2-5 | .286 | - | ESPNU | SECU Arena · Towson, MD |
| 8 | Sat Nov 30 | vs St Francis PA | L63-79 | 2-6 | .250 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 9 | Tue Dec 3 | vs Lafayette | L71-94 | 2-7 | .222 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 10 | Sat Dec 7 | vs #23Villanova | L66-78 | 2-8 | .200 | - | ESPN2 | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 11 | Tue Dec 10 | at Temple | L61-108 | 2-9 | .182 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 12 | Thu Dec 19 | vs William & Mary | W84-69 | 3-9 | .250 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 13 | Thu Jan 2 | at Richmond | L52-84 | 3-10 | .231 | - | | Robins Center · Richmond, VA |
| 14 | Sun Jan 5 | vs #20Dayton | L67-80 | 3-11 | .214 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 15 | Wed Jan 8 | vs Duquesne | L60-78 | 3-12 | .200 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 16 | Sat Jan 11 | at Davidson | L83-89 (OT) | 3-13 | .188 | - | NBCSN | John M. Belk Arena · Davidson, NC |
| 17 | Wed Jan 15 | vs Rhode Island | L61-71 | 3-14 | .176 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 18 | Sat Jan 18 | at Penn | W87-81 | 4-14 | .222 | - | | The Palestra · Philadelphia, PA |
| 19 | Tue Jan 21 | vs VCU | L60-73 | 4-15 | .211 | - | CBS | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 20 | Sat Jan 25 | at G Washington | L69-85 | 4-16 | .200 | - | | Charles E. Smith Center · Washington, D.C. |
| 21 | Wed Jan 29 | at UMass | L76-91 | 4-17 | .190 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 22 | Sat Feb 1 | vs Saint Louis | L73-78 | 4-18 | .182 | - | NBCSN | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 23 | Sat Feb 8 | at La Salle | L66-83 | 4-19 | .174 | - | NBCSN | Tom Gola Arena · Philadelphia, PA |
| 24 | Tue Feb 11 | vs St Bonaventure | L56-74 | 4-20 | .167 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 25 | Sat Feb 15 | atRhode Island | L55-73 | 4-21 | .160 | - | CBS | Ryan Center · Kingston, RI |
| 26 | Tue Feb 18 | vsDavidson | W73-72 | 5-21 | .192 | - | CBS | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 27 | Sat Feb 22 | at George Mason | L55-62 | 5-22 | .185 | - | | EagleBank Arena · Fairfax, VA |
| 28 | Wed Feb 26 | atSaint Louis | L63-76 | 5-23 | .179 | - | CBS | Chaifetz Arena · St. Louis, MO |
| 29 | Sat Feb 29 | vs Fordham | W73-69 | 6-23 | .207 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 30 | Wed Mar 4 | atSt Bonaventure | L73-89 | 6-24 | .200 | - | | Reilly Center · Saint Bonaventure, NY |
| 31 | Sat Mar 7 | vsLa Salle | L77-78 | 6-25 | .194 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 32 | Wed Mar 11 | atGeorge Mason | L70-77 | 6-26 | .188 | - | | EagleBank Arena · Fairfax, VA |
