| 1 | Mon Nov 3 | vs Lafayette | W85-76 | 1-0 | 1.000 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 2 | Sat Nov 8 | vsDrexel | W76-65 | 2-0 | 1.000 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 3 | Wed Nov 12 | atVirginia Tech | L59-94 | 2-1 | .667 | - | ACC Extra | Cassell Coliseum · Blacksburg, VA |
| 4 | Mon Nov 17 | atPenn | L74-83 | 2-2 | .500 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 5 | Thu Nov 20 | atUNLV | L85-99 | 2-3 | .400 | - | | Thomas & Mack Center · Las Vegas, NV |
| 6 | Tue Nov 25 | vsTBD | W100-61 | 3-3 | .500 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 7 | Sun Nov 30 | atPrinceton | W60-58 | 4-3 | .571 | - | | Jadwin Gymnasium · Princeton, NJ |
| 8 | Sat Dec 6 | atTemple | W70-69 | 5-3 | .625 | - | | Liacouras Center · Philadelphia, PA |
| 9 | Tue Dec 9 | vsCoppin St | W87-65 | 6-3 | .667 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 10 | Thu Dec 11 | atSyracuse | L63-71 | 6-4 | .600 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 11 | Thu Dec 18 | vsDelaware St | W67-51 | 7-4 | .636 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 12 | Mon Dec 22 | vsCoast Car | L62-68 | 7-5 | .583 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 13 | Sun Dec 28 | vsTBD | W87-65 | 8-5 | .615 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 14 | Wed Dec 31 | atSaint Louis | L79-102 | 8-6 | .571 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 15 | Sat Jan 3 | vsDavidson | L56-62 | 8-7 | .533 | - | CBSSN | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 16 | Wed Jan 7 | vsDuquesne | W97-90 (OT) | 9-7 | .563 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 17 | Sun Jan 11 | atRichmond | W67-65 | 10-7 | .588 | - | USA Net | Robins Center · Richmond, VA |
| 18 | Wed Jan 14 | vsSt Bonaventure | W68-64 | 11-7 | .611 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 19 | Mon Jan 19 | atVCU | L72-79 | 11-8 | .579 | - | CBSSN | Stuart C. Siegel Center · Richmond, VA |
| 20 | Sat Jan 24 | vsDayton | W81-74 | 12-8 | .600 | - | CBSSN | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 21 | Tue Jan 27 | atLoyola Chicago | W85-64 | 13-8 | .619 | - | CBSSN | Joseph J. Gentile Arena · Chicago, IL |
| 22 | Sat Jan 31 | atLa Salle | W67-58 | 14-8 | .636 | - | USA Net | Tom Gola Arena · Philadelphia, PA |
| 23 | Wed Feb 4 | vsG Washington | W76-73 | 15-8 | .652 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 24 | Sat Feb 7 | atGeorge Mason | L52-60 | 15-9 | .625 | - | ESPN+ | EagleBank Arena · Fairfax, VA |
| 25 | Tue Feb 10 | vsFordham | L64-68 | 15-10 | .600 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 26 | Wed Feb 18 | atSt Bonaventure | W71-65 | 16-10 | .615 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 27 | Sat Feb 21 | vsLoyola Chicago | W75-61 | 17-10 | .630 | - | ESPNU | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 28 | Wed Feb 25 | vsGeorge Mason | W81-63 | 18-10 | .643 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 29 | Sat Feb 28 | atRhode Island | W61-55 | 19-10 | .655 | - | ESPN+ | Ryan Center · Kingston, RI |
