| 1 | Tue Nov 9 | vs MD-Eastern | W69-67 | 1-0 | 1.000 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 2 | Sat Nov 13 | vs Mount St Mary | W80-60 | 2-0 | 1.000 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 3 | Wed Nov 17 | vs Drexel | L75-78 | 2-1 | .667 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 4 | Sat Nov 20 | vs Monmouth | L75-87 | 2-2 | .500 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 5 | Thu Nov 25 | vs USC | L55-70 | 2-3 | .400 | - | ESPN2 | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 6 | Fri Nov 26 | at Georgetown | W77-74 | 3-3 | .500 | - | ESPNU | Capital One Arena · Washington, D.C. |
| 7 | Wed Dec 1 | vs Binghamton | W79-57 | 4-3 | .571 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 8 | Sat Dec 4 | at #6Villanova | L52-81 | 4-4 | .500 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 9 | Wed Dec 8 | vs Penn | W78-71 | 5-4 | .556 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 10 | Sat Dec 11 | vs Temple | W68-49 | 6-4 | .600 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 11 | Sat Dec 18 | at Bradley | L73-77 | 6-5 | .545 | - | | Carver Arena · Peoria, IL |
| 13 | Thu Dec 30 | at Richmond | W83-56 | 7-5 | .583 | - | | Robins Center · Richmond, VA |
| 14 | Sun Jan 2 | vs G Washington | PPD | 11-19 | .367 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 15 | Wed Jan 5 | vs Davidson | L73-88 | 7-6 | .538 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 16 | Sat Jan 8 | at George Mason | PPD | 11-19 | .367 | - | | EagleBank Arena · Fairfax, VA |
| 17 | Wed Jan 12 | at Rhode Island | L64-75 | 7-7 | .500 | - | | Ryan Center · Kingston, RI |
| 18 | Mon Jan 17 | vs La Salle | L64-75 | 7-8 | .467 | - | CBS | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 19 | Wed Jan 19 | vsG Washington | W72-61 | 8-8 | .500 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 20 | Sat Jan 22 | at VCU | L54-70 | 8-9 | .471 | - | USA Net | Stuart C. Siegel Center · Richmond, VA |
| 21 | Mon Jan 24 | atGeorge Mason | L71-77 | 8-10 | .444 | - | | EagleBank Arena · Fairfax, VA |
| 22 | Wed Jan 26 | vs Duquesne | W72-61 | 9-10 | .474 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 23 | Sat Jan 29 | at St Bonaventure | L69-80 | 9-11 | .450 | - | USA Net | Reilly Center · Saint Bonaventure, NY |
| 24 | Sat Feb 5 | vs Fordham | W72-69 | 10-11 | .476 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 25 | Wed Feb 9 | atDavidson | L67-73 (OT) | 10-12 | .455 | - | | John M. Belk Arena · Davidson, NC |
| 26 | Sat Feb 12 | at UMass | L67-69 | 10-13 | .435 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 27 | Wed Feb 16 | vsGeorge Mason | L70-75 (OT) | 10-14 | .417 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 28 | Sat Feb 19 | vs Dayton | L62-74 | 10-15 | .400 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 29 | Tue Feb 22 | at Saint Louis | L61-72 | 10-16 | .385 | - | | Chaifetz Arena · St. Louis, MO |
| 30 | Sat Feb 26 | vsSt Bonaventure | L52-54 | 10-17 | .370 | - | CBS | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 31 | Wed Mar 2 | atLa Salle | L48-49 | 10-18 | .357 | - | | Tom Gola Arena · Philadelphia, PA |
| 32 | Sat Mar 5 | vsRhode Island | W70-60 | 11-18 | .379 | - | USA Net | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 33 | Wed Mar 9 | atLa Salle | L56-63 | 11-19 | .367 | - | | Tom Gola Arena · Philadelphia, PA |
Holy Cross