| 1 | Mon Nov 4 | vs New Hampshire | W103-74 | 1-0 | 1.000 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 2 | Fri Nov 8 | at West Virginia | L69-75 | 1-1 | .500 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 3 | Wed Nov 13 | vs Louisiana Tech | L66-76 | 1-2 | .333 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 4 | Sat Nov 16 | vs Hofstra | L71-75 (OT) | 1-3 | .250 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 5 | Sat Nov 23 | at Temple | L80-87 | 1-4 | .200 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 6 | Sun Nov 24 | vs Florida St | L59-92 | 1-5 | .167 | - | ESPN2 | William D. Mullins Memorial Center · Amherst, MA |
| 7 | Wed Nov 27 | at Harvard | W62-54 | 2-5 | .286 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 8 | Sun Dec 1 | vs NJIT | W80-68 | 3-5 | .375 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 9 | Wed Dec 4 | vs C Connecticut | L69-73 | 3-6 | .333 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 10 | Sat Dec 7 | vs UMass Lowell | L83-96 | 3-7 | .300 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 11 | Sat Dec 14 | vs TBD | W86-52 | 4-7 | .364 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 12 | Wed Dec 18 | vs Northeastern | W77-72 | 5-7 | .417 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 13 | Sat Dec 21 | vs Arizona St | L62-78 | 5-8 | .385 | - | CBS | William D. Mullins Memorial Center · Amherst, MA |
| 14 | Tue Dec 31 | at Saint Joseph's | L72-81 | 5-9 | .357 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 15 | Sat Jan 4 | vs Richmond | L64-72 | 5-10 | .333 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 16 | Wed Jan 8 | vs Dayton | W76-72 | 6-10 | .375 | - | Peacock | William D. Mullins Memorial Center · Amherst, MA |
| 17 | Sat Jan 11 | at George Mason | L70-77 | 6-11 | .353 | - | ESPN+ | EagleBank Arena · Fairfax, VA |
| 18 | Wed Jan 15 | at Fordham | W120-118 (3OT) | 7-11 | .389 | - | ESPN+ | Rose Hill Gymnasium · Bronx, NY |
| 19 | Sun Jan 19 | vs La Salle | W82-60 | 8-11 | .421 | - | USA Net | William D. Mullins Memorial Center · Amherst, MA |
| 20 | Wed Jan 22 | vs G Washington | W74-61 | 9-11 | .450 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 21 | Wed Jan 29 | at Rhode Island | L82-88 | 9-12 | .429 | - | ESPN+ | Ryan Center · Kingston, RI |
| 22 | Sat Feb 1 | at Duquesne | W62-53 | 10-12 | .455 | - | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 23 | Tue Feb 4 | vs Saint Louis | L71-73 | 10-13 | .435 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 24 | Sun Feb 9 | atLa Salle | W78-55 | 11-13 | .458 | - | | Tom Gola Arena · Philadelphia, PA |
| 25 | Wed Feb 12 | vs Davidson | L68-77 | 11-14 | .440 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 26 | Sat Feb 15 | vs St Bonaventure | L59-73 | 11-15 | .423 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 27 | Wed Feb 19 | at VCU | L51-80 | 11-16 | .407 | - | CBS | Stuart C. Siegel Center · Richmond, VA |
| 28 | Sat Feb 22 | atG Washington | L52-74 | 11-17 | .393 | - | ESPN+ | Charles E. Smith Center · Washington, D.C. |
| 29 | Sat Mar 1 | vsRhode Island | W91-88 | 12-17 | .414 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 30 | Wed Mar 5 | atSt Bonaventure | L72-73 | 12-18 | .400 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 31 | Sat Mar 8 | vs Loyola Chicago | L51-74 | 12-19 | .387 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 32 | Wed Mar 12 | vsLa Salle | L71-78 | 12-20 | .375 | - | USA Net | William D. Mullins Memorial Center · Amherst, MA |
