| 1 | Mon Nov 3 | vs Marshall | L72-78 | 0-1 | .000 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 2 | Sat Nov 8 | vsAlbany | W83-62 | 1-1 | .500 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 3 | Thu Nov 13 | vsLe Moyne | W94-80 | 2-1 | .667 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 4 | Sun Nov 16 | vsC Connecticut | W84-77 | 3-1 | .750 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 5 | Fri Nov 21 | atCharleston | L65-69 | 3-2 | .600 | - | ESPN+ | TD Arena · Charleston, SC |
| 6 | Sat Nov 22 | vsGreen Bay | L75-79 | 3-3 | .500 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 7 | Mon Nov 24 | atOregon St | W73-65 | 4-3 | .571 | - | | Gill Coliseum · Corvallis, OR |
| 8 | Wed Dec 3 | vsHarvard | W78-71 | 5-3 | .625 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 9 | Sat Dec 6 | vsUMass Lowell | W80-60 | 6-3 | .667 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 10 | Wed Dec 10 | atBoston College | W76-74 | 7-3 | .700 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
| 11 | Sat Dec 13 | atFlorida St | W103-95 | 8-3 | .727 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 12 | Sat Dec 20 | vsKent State | L59-69 | 8-4 | .667 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 13 | Mon Dec 22 | vsTBD | W91-40 | 9-4 | .692 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 14 | Tue Dec 30 | atE Michigan | L74-80 | 9-5 | .643 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 15 | Sat Jan 3 | vsBowling Green | L100-101 (OT) | 9-6 | .600 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 16 | Tue Jan 6 | atOhio | L83-86 | 9-7 | .563 | - | | Convocation Center (OH) · Athens, OH |
| 17 | Sat Jan 10 | vsBall State | W79-71 | 10-7 | .588 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 18 | Tue Jan 13 | atW Michigan | W85-82 | 11-7 | .611 | - | ESPN+ | University Arena (MI) · Kalamazoo, MI |
| 19 | Sat Jan 17 | atN Illinois | L68-70 | 11-8 | .579 | - | ESPN+ | NIU Convocation Center · Dekalb, IL |
| 20 | Tue Jan 20 | vsToledo | W84-82 | 12-8 | .600 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 21 | Fri Jan 23 | atBuffalo | W68-67 | 13-8 | .619 | - | CBSSN | Alumni Arena · Buffalo, NY |
| 22 | Tue Jan 27 | at24Miami OH | L84-86 | 13-9 | .591 | - | ESPNU | Millett Hall · Oxford, OH |
| 23 | Sat Jan 31 | vsE Michigan | W70-67 | 14-9 | .609 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 24 | Tue Feb 3 | vsC Michigan | W95-89 | 15-9 | .625 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 25 | Sat Feb 7 | atCoast Car | L91-94 (3OT) | 15-10 | .600 | - | ESPN+ | The HTC Center · Conway, SC |
| 26 | Fri Feb 13 | atAkron | L92-99 | 15-11 | .577 | - | CBSSN | James A. Rhodes Arena · Akron, OH |
| 27 | Tue Feb 17 | vs22Miami OH | L77-86 | 15-12 | .556 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 28 | Sat Feb 21 | vsBuffalo | L82-86 (OT) | 15-13 | .536 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 29 | Tue Feb 24 | atBall State | L73-74 (OT) | 15-14 | .517 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 30 | Sat Feb 28 | atBowling Green | L62-81 | 15-15 | .500 | - | ESPN+ | Stroh Center · Bowling Green, OH |
